• Carolina Witchmichen Penteado Schmidt


Commonly, pediatric hemato-oncologists are not accustomed to the peculiarities of drug therapy in neonatology, and so they need to pay attention to the issue of drug excipients—just as they should pay attention to avoiding preservative administration to neonates and infants.


  1. 1.
    Schmidt CWP, Menezes FG. Drug therapy and interactions in pediatric oncology: a pocket guide. Switzerland: Springer; 2017.Google Scholar
  2. 5.
    Kalász H, Antal I. Drug excipients. Curr Med Chem. 2006;13(21):2535–63.CrossRefGoogle Scholar
  3. 6.
    Yasaka WJ, Eichbaum FW, Oga S. Antiarrhythmic effects of solvents: III. Effects of propylene glycol and benzyl alcohol on contractile force of isolated rabbit heart. Cardiovasc Res. 1979;13(12):717–22. Accessed 3 Oct 2016.CrossRefGoogle Scholar
  4. 12.
    Allegaert K. Neonates need tailored drug formulations. World J Clin Pediatr. 2013;2(1):1–5. Accessed 6 Oct 2016.CrossRefGoogle Scholar
  5. 7.
    Agency for Toxic Substances and Disease Registry: Toxic Substances Portal. 2011. Accessed 3 Oct 2016.
  6. 8.
    Nair B. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate. Int J Toxicol. 2001;20(Suppl 3):23–50.PubMedGoogle Scholar
  7. 9.
    Masi S, de Cléty SC, Anslot C, Detaille T. Acute amiodarone toxicity due to an administration error: could excipient be responsible? Br J Clin Pharmacol. 2009;67(6):691–3.CrossRefGoogle Scholar
  8. 11.
    Graham S, Turner M. European Study of Neonatal Exposure to Excipients (ESNEE). Inf Dent. 2011;7(6):196–9. Accessed 3 Oct 2016.Google Scholar
  9. 4.
    Taketomo C, Hodding J, Kraus D. Pediatric & neonatal dosage handbook. 21st ed. Hudson: Lexicomp; 2014.Google Scholar
  10. 10.
    PubChem: Compound Summary. Accessed 3 Oct 2016.
  11. 13. Accessed 1 Nov 2016.
  12. 14.
    Lass J, Naelapää K, Shah U, et al. Hospitalised neonates in Estonia commonly receive potentially harmful excipients. BMC Pediatr. 2012;12:136.CrossRefGoogle Scholar
  13. 19.
    Kuschel C, Rowley S, Hughes B. Newborn services drug protocol: morphine hydrochloride. Auckland District Health Board. Accessed 10 Jan 2017.
  14. 56.
    Li Q, Shu Y. Role of solute carriers in response to anticancer drugs. Mol Cell Ther. 2014;2:15. CrossRefGoogle Scholar
  15. 53.
    Harvey RA, Mycek MJ. Farmacologia ilustrada. 5th ed. Porto Alegre: Artmed; 2013.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Carolina Witchmichen Penteado Schmidt
    • 1
  1. 1.CuritibaBrazil

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