Reflectance Confocal Microscopy in Pigmentary Disorders

  • Nesrine Brahimi
  • Pascale Guitera
Part of the Updates in Clinical Dermatology book series (UCD)


In vivo reflectance confocal microscopy (RCM) is a non-invasive tool for imaging the superficial layers of the skin. It has been recently introduced in dermatology practice. The RCM provides real-time, dynamic horizontal images that provide cellular and subcellular details in the depth of the skin.

Melanin is one of the main refractile targets of RCM (appears bright), so this technique is an interesting method of evaluation of both hyperpigmentary and hypopigmentary disorders (acquired pigmentary skin disorders such as melasma and vitiligo or melanocytic lesions such naevi and melanoma). The interpretation of the images must be done according to the clinical history and symptoms as in histopathology.


Reflectance Confocal microscopy Skin imaging Pigmentary disorders Melasma Vitiligo Melanoma Naevi 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Melanoma Diagnostic Centre, Royal Prince Alfred HospitalSydneyAustralia
  2. 2.Department of DermatologyMelanoma Diagnostic Centre, Royal Prince Alfred Hospital and Melanoma Institute Australia, University of SydneySydneyAustralia

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