Abstract
Management of the axilla in early breast cancer patients has significantly evolved in the last several decades. With the arrival of the sentinel lymph node biopsy, surgical practice for axillary staging in patients with early breast cancer has become gradually less invasive and formal axillary lymph node dissection has been confined to selected patients. Over the last two decades, evidence from randomized clinical trials have allowed for the de-escalation of axillary surgery in the management of early stage breast cancer. Advances in the staging and treatment of the axilla constitute a key component in determining initial surgical planning and therapeutic strategies in the treatment of early breast cancer. This chapter provides an updated review on the history, evolution, and current practices for axillary management in patients with early breast cancer, with particular attention to the surgical recommendations and controversial scenarios of the evolving management of the axilla.
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References
Veronesi U, Paganelli G, Viale G, Luini A, Zurrida S, Galimberti V et al (2003) A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med 349(6):546–553
Halsted WSI (1894) The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June, 1889, to January, 1894. Ann Surg 20(5):497–555
Adair F, Berg J, Joubert L, Robbins GF (1974) Long-term followup of breast cancer patients: the 30-year report. Cancer 33(4):1145–1150
Fisher B, Jeong JH, Anderson S, Bryant J, Fisher ER, Wolmark N (2002) Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med 347(8):567–575
Wickerham DL, Costantino JP, Mamounas EP, Julian TB (2006) The landmark surgical trials of the national surgical adjuvant breast and bowel project. World J Surg 30(7):1138–1146
Port ER, Tan LK, Borgen PI, Van Zee KJ (1998) Incidence of axillary lymph node metastases in T1a and T1b breast carcinoma. Ann Surg Oncol 5(1):23–27
Harris JR, Osteen RT (1985) Patients with early breast cancer benefit from effective axillary treatment. Breast Cancer Res Treat 5(1):17–21
Moore MP, Kinne DW (1996) Is axillary lymph node dissection necessary in the routine management of breast cancer? Yes. Important Adv Oncol 245–250
Alex JC, Weaver DL, Fairbank JT, Rankin BS, Krag DN (1993) Gamma-probe-guided lymph node localization in malignant melanoma. Surg Oncol 2(5):303–308
Giuliano AE, Kirgan DM, Guenther JM, Morton DL (1994) Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg 220(3):391–398. discussion 8–401
Albertini JJ, Lyman GH, Cox C, Yeatman T, Balducci L, Ku N et al (1996) Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. JAMA 276(22):1818–1822
Veronesi U, Galimberti V, Zurrida S, Pigatto F, Veronesi P, Robertson C et al (2001) Sentinel lymph node biopsy as an indicator for axillary dissection in early breast cancer. Eur J Cancer 37(4):454–458
Zakaria S, Hoskin TL, Degnim AC (2008) Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer. Am J Surg 196(2):228–233
Blessing WD, Stolier AJ, Teng SC, Bolton JS, Fuhrman GM (2002) A comparison of methylene blue and lymphazurin in breast cancer sentinel node mapping. Am J Surg 184(4):341–345
Chung A, Yu J, Stempel M, Patil S, Cody H, Montgomery L (2008) Is the “10% rule” equally valid for all subsets of sentinel-node-positive breast cancer patients? Ann Surg Oncol 15(10):2728–2733
Newman LA (2004) Lymphatic mapping and sentinel lymph node biopsy in breast cancer patients: a comprehensive review of variations in performance and technique. J Am Coll Surg 199(5):804–816
Montgomery LL, Thorne AC, Van Zee KJ, Fey J, Heerdt AS, Gemignani M et al (2002) Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer. Anesth Analg 95(2):385–388 (table of contents)
Borgstein PJ, Meijer S, Pijpers R (1997) Intradermal blue dye to identify sentinel lymph-node in breast cancer. Lancet 349(9066):1668–1669
Stradling B, Aranha G, Gabram S (2002) Adverse skin lesions after methylene blue injections for sentinel lymph node localization. Am J Surg 184(4):350–352
Brady EW (2002) Sentinel lymph node mapping following neoadjuvant chemotherapy for breast cancer. Breast J. 8(2):97–100
Kern KA (1999) Sentinel lymph node mapping in breast cancer using subareolar injection of blue dye. J Am Coll Surg 189(6):539–545
Klimberg VS, Rubio IT, Henry R, Cowan C, Colvert M, Korourian S (1999) Subareolar versus peritumoral injection for location of the sentinel lymph node. Ann Surg 229(6):860–864 (discussion 4–5)
Veronesi U, Viale G, Paganelli G, Zurrida S, Luini A, Galimberti V et al (2010) Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study. Ann Surg 251(4):595–600
Krag DN, Anderson SJ, Julian TB, Brown AM, Harlow SP, Costantino JP et al (2010) Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol. 11(10):927–933
Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW et al (2011) Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 305(6):569–575
Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P et al (2013) Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial. Lancet Oncol. 14(4):297–305
Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE et al (2014) Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 15(12):1303–1310
Nagaraja V, Edirimanne S, Eslick GD (2016) Is sentinel lymph node biopsy necessary in patients undergoing prophylactic mastectomy? A systematic review and meta-analysis. Breast J. 22(2):158–165
Boughey JC, Khakpour N, Meric-Bernstam F, Ross MI, Kuerer HM, Singletary SE et al (2006) Selective use of sentinel lymph node surgery during prophylactic mastectomy. Cancer 107(7):1440–1447
Boughey JC, Attai DJ, Chen SL, Cody HS, Dietz JR, Feldman SM et al (2016) Contralateral prophylactic mastectomy (CPM) consensus statement from the American Society of Breast Surgeons: data on CPM outcomes and risks. Ann Surg Oncol 23(10):3100–3105
Jin Kim H, Heerdt AS, Cody HS, Van Zee KJ (2002) Sentinel lymph node drainage in multicentric breast cancers. Breast J. 8(6):356–361
Kumar R, Jana S, Heiba SI, Dakhel M, Axelrod D, Siegel B et al (2003) Retrospective analysis of sentinel node localization in multifocal, multicentric, palpable, or nonpalpable breast cancer. J Nucl Med 44(1):7–10
Tousimis E, Van Zee KJ, Fey JV, Hoque LW, Tan LK, Cody HS 3rd et al (2003) The accuracy of sentinel lymph node biopsy in multicentric and multifocal invasive breast cancers. J Am Coll Surg 197(4):529–535
Pierga JY, Girre V, Laurence V, Asselain B, Dieras V, Jouve M et al (2004) Characteristics and outcome of 1755 operable breast cancers in women over 70 years of age. Breast 13(5):369–375
Diab SG, Elledge RM, Clark GM (2000) Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst 92(7):550–556
International Breast Cancer Study G, Rudenstam CM, Zahrieh D, Forbes JF, Crivellari D, Holmberg SB et al (2006) Randomized trial comparing axillary clearance versus no axillary clearance in older patients with breast cancer: first results of International Breast Cancer Study Group Trial 10–93. J Clin Oncol 24(3):337–344
Mc CD, Gemignani ML (2016) Current management of the Axilla. Clin Obstet Gynecol 59(4):743–755
Hughes KS, Schnaper LA, Bellon JR, Cirrincione CT, Berry DA, McCormick B et al (2013) Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol 31(19):2382–2387
Pesce C, Czechura T, Winchester DJ, Huo D, Winchester DP, Yao K (2013) Axillary surgery among estrogen receptor positive women 70 years of age or older with clinical stage I breast cancer, 2004–2010: a report from the National Cancer Data Base. Ann Surg Oncol 20(10):3259–3265
Martelli G, Boracchi P, Ardoino I, Lozza L, Bohm S, Vetrella G et al (2012) Axillary dissection versus no axillary dissection in older patients with T1N0 breast cancer: 15-year results of a randomized controlled trial. Ann Surg 256(6):920–924
Martelli G, Boracchi P, Orenti A, Lozza L, Maugeri I, Vetrella G et al (2014) Axillary dissection versus no axillary dissection in older T1N0 breast cancer patients: 15-year results of trial and out-trial patients. Eur J Surg Oncol 40(7):805–812
Liang S, Hallet J, Simpson JS, Tricco AC, Scheer AS (2016) Omission of axillary staging in elderly patients with early stage breast cancer impacts regional control but not survival: a systematic review and meta-analysis. J Geriatr Oncol 140–147
Gradishar WJ, Anderson BO, Balassanian R, Blair SL, Burstein HJ, Cyr A, et al (2017) Breast cancer, Version 2.2017: National Comprehensive Cancer Network; 6 Apr 2017. Available from: https://www.nccn.org/professionals/physician_gls/f_guidelines.asp
Viale G, Zurrida S, Maiorano E, Mazzarol G, Pruneri G, Paganelli G et al (2005) Predicting the status of axillary sentinel lymph nodes in 4351 patients with invasive breast carcinoma treated in a single institution. Cancer 103(3):492–500
Heuts EM, van der Ent FW, Kengen RA, van der Pol HA, Hulsewe KW, Hoofwijk AG (2006) Results of sentinel node biopsy not affected by previous excisional biopsy. Eur J Surg Oncol 32(3):278–281
Renaudeau C, Lefebvre-Lacoeuille C, Campion L, Dravet F, Descamps P, Ferron G et al (2016) Evaluation of sentinel lymph node biopsy after previous breast surgery for breast cancer: GATA study. Breast 28:54–59
Haigh PI, Hansen NM, Qi K, Giuliano AE (2000) Biopsy method and excision volume do not affect success rate of subsequent sentinel lymph node dissection in breast cancer. Ann Surg Oncol 7(1):21–27
Port ER, Fey J, Gemignani ML, Heerdt AS, Montgomery LL, Petrek JA et al (2002) Reoperative sentinel lymph node biopsy: a new option for patients with primary or locally recurrent breast carcinoma. J Am Coll Surg 195(2):167–172
Intra M, Trifiro G, Viale G, Rotmensz N, Gentilini OD, Soteldo J et al (2005) Second biopsy of axillary sentinel lymph node for reappearing breast cancer after previous sentinel lymph node biopsy. Ann Surg Oncol 12(11):895–899
Maaskant-Braat AJ, Voogd AC, Roumen RM, Nieuwenhuijzen GA (2013) Repeat sentinel node biopsy in patients with locally recurrent breast cancer: a systematic review and meta-analysis of the literature. Breast Cancer Res Treat 138(1):13–20
Lyman GH, Giuliano AE, Somerfield MR, Benson AB 3rd, Bodurka DC, Burstein HJ et al (2005) American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol 23(30):7703–7720
Loibl S, von Minckwitz G, Gwyn K, Ellis P, Blohmer JU, Schlegelberger B et al (2006) Breast carcinoma during pregnancy. International recommendations from an expert meeting. Cancer 106(2):237–246
Schwartz GF, Giuliano AE, Veronesi U, Consensus Conference C (2002) Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast April 19 to 22, 2001, Philadelphia, Pennsylvania. Hum Pathol 33(6):579–589
Lyman GH, Somerfield MR, Bosserman LD, Perkins CL, Weaver DL, Giuliano AE (2016) Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol JCO2016710947 (Epub ahead of print)
Lyman GH, Temin S, Edge SB, Newman LA, Turner RR, Weaver DL et al (2014) Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 32(13):1365–1383
Gentilini O, Cremonesi M, Trifiro G, Ferrari M, Baio SM, Caracciolo M et al (2004) Safety of sentinel node biopsy in pregnant patients with breast cancer. Ann Oncol 15(9):1348–1351
Gentilini O, Cremonesi M, Toesca A, Colombo N, Peccatori F, Sironi R et al (2010) Sentinel lymph node biopsy in pregnant patients with breast cancer. Eur J Nucl Med Mol Imaging 37(1):78–83
Toesca A, Luini A, Veronesi P, Intra M, Gentilini O (2011) Sentinel lymph node biopsy in early breast cancer: the experience of the European Institute of Oncology in Special Clinical Scenarios. Breast Care (Basel). 6(3):208–214
Spanheimer PM, Graham MM, Sugg SL, Scott-Conner CE, Weigel RJ (2009) Measurement of uterine radiation exposure from lymphoscintigraphy indicates safety of sentinel lymph node biopsy during pregnancy. Ann Surg Oncol 16(5):1143–1147
Morita ET, Chang J, Leong SP (2000) Principles and controversies in lymphoscintigraphy with emphasis on breast cancer. Surg Clin North Am 80(6):1721–1739
Gropper AB, Calvillo KZ, Dominici L, Troyan S, Rhei E, Economy KE et al (2014) Sentinel lymph node biopsy in pregnant women with breast cancer. Ann Surg Oncol 21(8):2506–2511
Pandit-Taskar N, Dauer LT, Montgomery L, St Germain J, Zanzonico PB, Divgi CR (2006) Organ and fetal absorbed dose estimates from 99mTc-sulfur colloid lymphoscintigraphy and sentinel node localization in breast cancer patients. J Nucl Med 47(7):1202–1208
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Valero, M.G., Golshan, M. (2018). Management of the Axilla in Early Breast Cancer. In: Gradishar, W. (eds) Optimizing Breast Cancer Management. Cancer Treatment and Research, vol 173. Springer, Cham. https://doi.org/10.1007/978-3-319-70197-4_4
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DOI: https://doi.org/10.1007/978-3-319-70197-4_4
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