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Sex Differences in Muscle Wasting

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1043)

Abstract

With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration. Decreased food intake and physical activity also indirectly contribute to muscle wasting. Sex hormones also play important roles in maintaining skeletal muscle homeostasis. Testosterone is a potent anabolic factor promoting muscle protein synthesis and muscular regeneration. Estrogens have a protective effect on skeletal muscle by attenuating inflammation; however, the mechanisms of estrogen action in skeletal muscle are less well characterized than those of testosterone. Age- and/or disease-induced alterations in sex hormones are major contributors to muscle wasting. Hence, men and women may respond differently to catabolic conditions because of their hormonal profiles. Here we review the similarities and differences between men and women with common wasting conditions including sarcopenia and cachexia due to cancer, end-stage renal disease/chronic kidney disease, liver disease, chronic heart failure, and chronic obstructive pulmonary disease based on the literature in clinical studies. In addition, the responses in men and women to the commonly used therapeutic agents and their efficacy to improve muscle mass and function are also reviewed.

Keywords

  • Muscle Wasting
  • Satellite Cell Senescence
  • Improve Muscle Mass
  • Sarcopenia
  • Chronic Obstructive Pulmonary Disease

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 1

References

  • Abs, R., Bengtsson, B. A., Hernberg-Stahl, E., Monson, J. P., Tauber, J. P., Wilton, P., & Wuster, C. (1999). GH replacement in 1034 growth hormone deficient hypopituitary adults: Demographic and clinical characteristics, dosing and safety. Clinical Endocrinology, 50, 703–713.

    CAS  CrossRef  PubMed  Google Scholar 

  • Adams, V., Jiang, H., Yu, J. T., Mobius-Winkler, S., Fiehn, E., Linke, A., Weigl, C., Schuler, G., & Hambrecht, R. (1999). Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance. Journal of the American College of Cardiology, 33, 959–965.

    CAS  CrossRef  PubMed  Google Scholar 

  • Adunsky, A., Chandler, J., Heyden, N., Lutkiewicz, J., Scott, B. B., Berd, Y., Liu, N., & Papanicolaou, D. A. (2011). MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: A multicenter, randomized, placebo-controlled phase IIb study. Archives of Gerontology and Geriatrics, 53, 183–189.

    CAS  CrossRef  PubMed  Google Scholar 

  • Ali, S., & Garcia, J. M. (2014). Sarcopenia, cachexia and aging: Diagnosis, mechanisms and therapeutic options – a mini-review. Gerontology, 60, 294–305.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Ali, S., Chen, J. A., & Garcia, J. M. (2013). Clinical development of ghrelin axis-derived molecules for cancer cachexia treatment. Current Opinion in Supportive and Palliative Care, 7, 368–375.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Allan, G. F., Tannenbaum, P., Sbriscia, T., Linton, O., Lai, M. T., Haynes-Johnson, D., Bhattacharjee, S., Zhang, X., Sui, Z., & Lundeen, S. G. (2007). A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats. Endocrine, 32, 41–51.

    CAS  CrossRef  PubMed  Google Scholar 

  • Amirouche, A., Durieux, A. C., Banzet, S., Koulmann, N., Bonnefoy, R., Mouret, C., Bigard, X., Peinnequin, A., & Freyssenet, D. (2009). Down-regulation of Akt/mammalian target of rapamycin signaling pathway in response to myostatin overexpression in skeletal muscle. Endocrinology, 150, 286–294.

    CAS  CrossRef  PubMed  Google Scholar 

  • Anderson, L. J., Albrecht, E. D., & Garcia, J. M. (2017). Update on management of cancer-related cachexia. Current Oncology Reports, 19, 3.

    CrossRef  CAS  PubMed  Google Scholar 

  • Anker, S. D. (1997). Wasting as an independent risk factor for mortality in chronic heart failure (vol 349, pg 1052, 1997). Lancet, 349, 1258–1258.

    CrossRef  Google Scholar 

  • Anker, S. D., Ponikowski, P. P., Clark, A. L., Leyva, F., Rauchhaus, M., Kemp, M., Teixeira, M. M., Hellewell, P. G., Hooper, J., Poole-Wilson, P. A., & Coats, A. J. S. (1999). Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure. European Heart Journal, 20, 683–693.

    CAS  CrossRef  PubMed  Google Scholar 

  • Anker, S. D., Volterrani, M., Pflaum, C. D., Strasburger, C. J., Osterziel, K. J., Doehner, W., Ranke, M. B., Poole-Wilson, P. A., Giustina, A., Dietz, R., & Coats, A. J. S. (2001). Acquired growth hormone resistance in patients with chronic heart failure: Implications for therapy with growth hormone. Journal of the American College of Cardiology, 38, 443–452.

    CAS  CrossRef  PubMed  Google Scholar 

  • Anker, S. D., Negassa, A., Coats, A. J. S., Afzal, R., Poole-Wilson, P. A., Cohn, J. N., & Yusuf, S. (2003). Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: An observational study. Lancet, 361, 1077–1083.

    CAS  CrossRef  PubMed  Google Scholar 

  • Aquilani, R., Opasich, C., Guagco, A., Verri, M., Testa, A., Pasini, E., Viglio, S., Iadarola, P., Pastoris, O., Dossena, M., & Boschi, F. (2008). Adequate energy-protein intake is not enough to improve nutritional and metabolic status in muscle-depleted patients with chronic heart failure. European Journal of Heart Failure, 10, 1127–1135.

    CAS  CrossRef  PubMed  Google Scholar 

  • Araujo, J. P., Lourenco, P., Rocha-Goncalves, F., Ferreira, A., & Bettencourt, P. (2009). Adiponectin is increased in cardiac cachexia irrespective of body mass index. European Journal of Heart Failure, 11, 567–572.

    CAS  CrossRef  PubMed  Google Scholar 

  • Arthur, S. T., Noone, J. M., Van Doren, B. A., Roy, D., & Blanchette, C. M. (2014). One-year prevalence, comorbidities and cost of cachexia-related inpatient admissions in the USA. Drugs Context, 3, 212265.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Bach, M. A., Rockwood, K., Zetterberg, C., Thamsborg, G., Hebert, R., Devogelaer, J. P., Christiansen, J. S., Rizzoli, R., Ochsner, J. L., Beisaw, N., Gluck, O., Yu, L., Schwab, T., Farrington, J., Taylor, A. M., Ng, J., Fuh, V., & Group, M. K. H. F. S. (2004). The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. Journal of the American Geriatrics Society, 52, 516–523.

    CrossRef  PubMed  Google Scholar 

  • Backer, J. M. (2008). The regulation and function of Class III PI3Ks: Novel roles for Vps34. The Biochemical Journal, 410, 1–17.

    CAS  CrossRef  PubMed  Google Scholar 

  • Baracos, V. E., Reiman, T., Mourtzakis, M., Gioulbasanis, I., & Antoun, S. (2010). Body composition in patients with non-small cell lung cancer: A contemporary view of cancer cachexia with the use of computed tomography image analysis. American Journal of Clinical Nutrition, 91, 1133s–1137s.

    CAS  CrossRef  PubMed  Google Scholar 

  • Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., Choong, K., lakshman, K. M., Mazer, N. A., Miciek, R., Krasnoff, J., Elmi, A., Knapp, P. E., Brooks, B., Appleman, E., Aggarwal, S., Bhasin, G., Hede-Brierley, L., Bhatia, A., Collins, L., Lebrasseur, N., Fiore, L. D., & Bhasin, S. (2010). Adverse events associated with testosterone administration. The New England Journal of Medicine, 363, 109–122.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Basualto-Alarcon, C., Varela, D., Duran, J., Maass, R., & Estrada, M. (2014). Sarcopenia and androgens: A link between pathology and treatment. Frontier Endocrinology (Lausanne), 5, 217.

    Google Scholar 

  • Batista, M. L., Peres, S. B., McDonald, M. E., Alcantara, P. S. M., Olivan, M., Otoch, J. P., Farmer, S. R., & Seelaender, M. (2012). Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors. Cytokine, 57, 9–16.

    CAS  CrossRef  PubMed  Google Scholar 

  • Baumann, C. W., Kwak, D., Liu, H. M., & Thompson, L. V. (2016). Age-induced oxidative stress: How does it influence skeletal muscle quantity and quality? Journal Applied Physiology (1985), 121, 1047–1052.

    CAS  CrossRef  Google Scholar 

  • Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J. (1999). Predictors of skeletal muscle mass in elderly men and women. Mechanisms of Ageing and Development, 107, 123–136.

    CAS  CrossRef  PubMed  Google Scholar 

  • Bea, J. W., Zhao, Q., Cauley, J. A., Lacroix, A. Z., Bassford, T., Lewis, C. E., Jackson, R. D., Tylavsky, F. A., & Chen, Z. (2011). Effect of hormone therapy on lean body mass, falls, and fractures: 6-year results from the Women’s Health Initiative hormone trials. Menopause, 18, 44–52.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Beaudart, C., Buckinx, F., Rabenda, V., Gillain, S., Cavalier, E., Slomian, J., Petermans, J., Reginster, J. Y., & Bruyere, O. (2014). The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials. The Journal of Clinical Endocrinology and Metabolism, 99, 4336–4345.

    CAS  CrossRef  PubMed  Google Scholar 

  • Bekfani, T., Pellicori, P., Morris, D. A., Ebner, N., Valentova, M., Steinbeck, L., Wachter, R., Elsner, S., Sliziuk, V., Schefold, J. C., Sandek, A., Doehner, W., Cleland, J. G., Lainscak, M., Anker, S. D., & Von Haehling, S. (2016). Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of life. International Journal of Cardiology, 222, 41–46.

    CrossRef  PubMed  Google Scholar 

  • Bhasin, S., & Jasuja, R. (2009). Selective androgen receptor modulators as function promoting therapies. Current Opinion in Clinical Nutrition and Metabolic Care, 12, 232–240.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Bhasin, S., Calof, O. M., Storer, T. W., Lee, M. L., Mazer, N. A., Jasuja, R., Montori, V. M., Gao, W., & Dalton, J. T. (2006a). Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nature Clinical Practice. Endocrinology & Metabolism, 2, 146–159.

    CAS  CrossRef  Google Scholar 

  • Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006b). Testosterone therapy in adult men with androgen deficiency syndromes: An endocrine society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 91, 1995–2010.

    CAS  CrossRef  PubMed  Google Scholar 

  • Biesemann, N., Mendler, L., Wietelmann, A., Hermann, S., Schafers, M., Kruger, M., Boettger, T., Borchardt, T., & Braun, T. (2014). Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circulation Research, 115, 296–310.

    CAS  CrossRef  PubMed  Google Scholar 

  • Blackman, M. R., Sorkin, J. D., Munzer, T., Bellantoni, M. F., Busby-Whitehead, J., Stevens, T. E., Jayme, J., O’Connor, K. G., Christmas, C., Tobin, J. D., Stewart, K. J., Cottrell, E., St Clair, C., Pabst, K. M., & Harman, S. M. (2002). Growth hormone and sex steroid administration in healthy aged women and men: A randomized controlled trial. JAMA, 288, 2282–2292.

    CAS  CrossRef  PubMed  Google Scholar 

  • Boland, R., Vasconsuelo, A., Milanesi, L., Ronda, A. C., & De Boland, A. R. (2008). 17beta-estradiol signaling in skeletal muscle cells and its relationship to apoptosis. Steroids, 73, 859–863.

    CAS  CrossRef  PubMed  Google Scholar 

  • Bonkovsky, H. L., Fiellin, D. A., Smith, G. S., Slaker, D. P., Simon, D., & Galambos, J. T. (1991). A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral-nutrition and oxandrolone. 1. Short-term effects on liver-function. American Journal of Gastroenterology, 86, 1200–1208.

    CAS  PubMed  Google Scholar 

  • Budoff, M. J., Ellenberg, S. S., Lewis, C. E., Mohler, E. R., 3rd, Wenger, N. K., Bhasin, S., Barrett-Connor, E., Swerdloff, R. S., Stephens-Shields, A., Cauley, J. A., Crandall, J. P., Cunningham, G. R., Ensrud, K. E., Gill, T. M., Matsumoto, A. M., Molitch, M. E., Nakanishi, R., Nezarat, N., Matsumoto, S., Hou, X., Basaria, S., Diem, S. J., Wang, C., Cifelli, D., & Snyder, P. J. (2017). Testosterone treatment and coronary artery plaque volume in older men with low testosterone. JAMA, 317, 708–716.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Cabello-Verrugio, C., Cordova, G., & Salas, J. D. (2012). Angiotensin II: Role in skeletal muscle atrophy. Current Protein & Peptide Science, 13, 560–569.

    CAS  CrossRef  Google Scholar 

  • Calnan, D. R., & Brunet, A. (2008). The FoxO code. Oncogene, 27, 2276–2288.

    CAS  CrossRef  PubMed  Google Scholar 

  • Caminiti, G., Volterrani, M., Iellamo, F., Marazzi, G., Massaro, R., Miceli, M., Mammi, C., Piepoli, M., Fini, M., & Rosano, G. M. C. (2009). Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. Journal of the American College of Cardiology, 54, 919–927.

    CAS  CrossRef  PubMed  Google Scholar 

  • Campbell, M. J., Mccomas, A. J., & Petito, F. (1973). Physiological changes in ageing muscles. Journal of Neurology, Neurosurgery, and Psychiatry, 36, 174–182.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Cappola, A. R., Ratcliffe, S. J., Bhasin, S., Blackman, M. R., Cauley, J., Robbins, J., Zmuda, J. M., Harris, T., & Fried, L. P. (2007). Determinants of serum total and free testosterone levels in women over the age of 65 years. The Journal of Clinical Endocrinology and Metabolism, 92, 509–516.

    CAS  CrossRef  PubMed  Google Scholar 

  • Carrero, J. J., Chmielewski, M., Axelsson, J., Snaedal, S., Heimburger, O., Barany, P., Suliman, M. E., Lindholm, B., Stenvinkel, P., & Qureshi, A. R. (2008). Muscle atrophy, inflammation and clinical outcome in incident and prevalent dialysis patients. Clinical Nutrition, 27, 557–564.

    CrossRef  PubMed  Google Scholar 

  • Carrero, J. J., Stenvinkel, P., Cuppari, L., Ikizler, T. A., Kalantar-Zadeh, K., Kaysen, G., Mitch, W. E., Price, S. R., Wanner, C., Wang, A. Y., Ter Wee, P., & Franch, H. A. (2013). Etiology of the protein-energy wasting syndrome in chronic kidney disease: A consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). Journal of Renal Nutrition, 23, 77–90.

    CrossRef  PubMed  Google Scholar 

  • Carson, J. A., & Manolagas, S. C. (2015). Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease. Bone, 80, 67–78.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Carter, A., Dobridge, J., & Hackney, A. C. (2001). Influence of estrogen on markers of muscle tissue damage following eccentric exercise. Fiziologiia Cheloveka, 27, 133–137.

    CAS  PubMed  Google Scholar 

  • Casaburi, R., Bhasin, S., Cosentino, L., Porszasz, J., Somfay, A., Lewis, M. I., Fournier, M., & Storer, T. W. (2004). Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 170, 870–878.

    CrossRef  PubMed  Google Scholar 

  • Cheema, B., Abas, H., Smith, B., O’Sullivan, A., Chan, M., Patwardhan, A., Kelly, J., Gillin, A., Pang, G., Lloyd, B., & Singh, M. F. (2007a). Progressive exercise for anabolism in kidney disease (PEAK): A randomized, controlled trial of resistance training during hemodialysis. Journal of the American Society of Nephrology, 18, 1594–1601.

    CrossRef  PubMed  Google Scholar 

  • Cheema, B., Abas, H., Smith, B., O’Sullivan, A., Chan, M., Patwardhan, A., Kelly, J., Gillin, A., Pang, G., Lloyd, B., & Singh, M. F. (2007b). Randomized controlled trial of intradialytic resistance training to target muscle wasting in ESRD: The progressive exercise for anabolism in kidney disease (PEAK) study. American Journal of Kidney Diseases, 50, 574–584.

    CrossRef  PubMed  Google Scholar 

  • Chen, J., Kim, J., & Dalton, J. T. (2005). Discovery and therapeutic promise of selective androgen receptor modulators. Molecular Interventions, 5, 173–188.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Christensen, H. M., Kistorp, C., Schou, M., Keller, N., Zerahn, B., Frystyk, J., Schwarz, P., & Faber, J. (2013). Prevalence of cachexia in chronic heart failure and characteristics of body composition and metabolic status. Endocrine, 43, 626–634.

    CAS  CrossRef  PubMed  Google Scholar 

  • Churchward-Venne, T. A., Breen, L., & Phillips, S. M. (2014). Alterations in human muscle protein metabolism with aging: Protein and exercise as countermeasures to offset sarcopenia. BioFactors, 40, 199–205.

    CAS  CrossRef  PubMed  Google Scholar 

  • Cianciaruso, B., Brunori, G., Kopple, J. D., Traverso, G., Panarello, G., Enia, G., Strippoli, P., Devecchi, A., Querques, M., Viglino, G., Vonesh, E., & Maiorca, R. (1995). Cross-sectional comparison of malnutrition in continuous ambulatory peritoneal-dialysis and hemodialysis-patients. American Journal of Kidney Diseases, 26, 475–486.

    CAS  CrossRef  PubMed  Google Scholar 

  • Cicoira, M., Kalra, P. R., & Anker, S. D. (2003). Growth hormone resistance in chronic heart failure and its therapeutic implications. Journal of Cardiac Failure, 9, 219–226.

    CAS  CrossRef  PubMed  Google Scholar 

  • Clarke, B. A., Drujan, D., Willis, M. S., Murphy, L. O., Corpina, R. A., Burova, E., Rakhilin, S. V., Stitt, T. N., Patterson, C., Latres, E., & Glass, D. J. (2007). The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metabolism, 6, 376–385.

    CAS  CrossRef  PubMed  Google Scholar 

  • Coats, A. J. S., Ho, G. F., Prabhash, K., Von Haehling, S., Tilson, J., Brown, R., Beadle, J., Anker, S. D., & GRP, A.-O. S. (2016). Espindolol for the treatment and prevention of cachexia in patients with stage III/IV non-small cell lung cancer or colorectal cancer: A randomized, double-blind, placebo-controlled, international multicentre phase II study (the ACT-ONE trial). Journal of Cachexia, Sarcopenia and Muscle, 7, 355–365.

    CrossRef  Google Scholar 

  • Codes, L., Asselah, T., Cazals-Hatem, D., Tubach, F., Vidaud, D., Parana, R., Bedossa, P., Valla, D., & Marcellin, P. (2007). Liver fibrosis in women with chronic hepatitis C: Evidence for the negative role of the menopause and steatosis and the potential benefit of hormone replacement therapy. Gut, 56, 390–395.

    CrossRef  PubMed  Google Scholar 

  • Cohen, S., Brault, J. J., Gygi, S. P., Glass, D. J., Valenzuela, D. M., Gartner, C., Latres, E., & Goldberg, A. L. (2009). During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. The Journal of Cell Biology, 185, 1083–1095.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Cohn, L., Feller, A. G., Draper, M. W., Rudman, I. W., & Rudman, D. (1993). Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-I concentrations. Clinical Endocrinology, 39, 417–425.

    CAS  CrossRef  PubMed  Google Scholar 

  • Constantin, D., Menon, M. K., Houchen-Wolloff, L., Morgan, M. D., Singh, S. J., Greenhaff, P., & Steiner, M. C. (2013). Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD. Thorax, 68, 625–633.

    CrossRef  PubMed  Google Scholar 

  • Crawford, J., Johnston, M. A., Taylor, R. P., Dalton, J. T., & Steiner, M. S. (2014). Enobosarm and lean body mass in patients with non-small cell lung cancer. Journal of Clinical Oncology, 32, 9618–9618.

    CrossRef  Google Scholar 

  • Creutzberg, E. C., Wouters, E. F., Mostert, R., Pluymers, R. J., & Schols, A. M. (2003). A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial. Chest, 124, 1733–1742.

    CAS  CrossRef  PubMed  Google Scholar 

  • Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J. P., Rolland, Y., Schneider, S. M., Topinkova, E., Vandewoude, M., Zamboni, M., & European Working Group on Sarcopenia in Older, P. (2010). Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing, 39, 412–423.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Cunha, T. F., Bacurau, A. V. N., Moreira, J. B. N., Paixao, N. A., Campos, J. C., Ferreira, J. C. B., Leal, M. L., Negrao, C. E., Moriscot, A. S., Wisloff, U., & Brum, P. C. (2012). Exercise training prevents oxidative stress and ubiquitin-proteasome system overactivity and reverse skeletal muscle atrophy in heart failure. Plos One, 7, e41701.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Dalton, J. T., Barnette, K. G., Bohl, C. E., Hancock, M. L., Rodriguez, D., Dodson, S. T., Morton, R. A., & Steiner, M. S. (2011). The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: Results of a double-blind, placebo-controlled phase II trial. Journal of Cachexia, Sarcopenia and Muscle, 2, 153–161.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Dasarathy, S., & Merli, M. (2016). Sarcopenia from mechanism to diagnosis and treatment in liver disease. Journal of Hepatology, 65, 1232–1244.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • De Brito-Ashurst, I., Varagunam, M., Raftery, M. J., & Yaqoob, M. M. (2009). Bicarbonate supplementation slows progression of CKD and improves nutritional status. Journal of the American Society of Nephrology, 20, 2075–2084.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Del Fabbro, E., Hui, D., Nooruddin, Z. I., Dalal, S., Dev, R., Freer, G., Roberts, L., Palmer, J. L., & Bruera, E. (2010). Associations among hypogonadism, C-reactive protein, symptom burden, and survival in male cancer patients with cachexia: A preliminary report. Journal of Pain and Symptom Management, 39, 1016–1024.

    CrossRef  PubMed  Google Scholar 

  • Del Fabbro, E., Garcia, J. M., Dev, R., Hui, D., Williams, J., Engineer, D., Palmer, J. L., Schover, L., & Bruera, E. (2013). Testosterone replacement for fatigue in hypogonadal ambulatory males with advanced cancer: A preliminary double-blind placebo-controlled trial. Support Care Cancer, 21, 2599–2607.

    CAS  CrossRef  PubMed  Google Scholar 

  • Dennison, E. M., Sayer, A. A., & Cooper, C. (2017). Epidemiology of sarcopenia and insight into possible therapeutic targets. Nature Reviews Rheumatology, 13, 340–347.

    CAS  CrossRef  PubMed  Google Scholar 

  • Dieli-Conwright, C. M., Spektor, T. M., Rice, J. C., Sattler, F. R., & Schroeder, E. T. (2009). Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women. Journal Applied Physiology (1985), 107, 853–858.

    CAS  CrossRef  Google Scholar 

  • Dieli-Conwright, C. M., Spektor, T. M., Rice, J. C., Sattler, F. R., & Schroeder, E. T. (2012). Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women. Journal of Strength and Conditioning Research, 26, 1374–1382.

    CrossRef  PubMed  Google Scholar 

  • Dobs, A. S., Nguyen, T., Pace, C., & Roberts, C. P. (2002). Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. The Journal of Clinical Endocrinology and Metabolism, 87, 1509–1516.

    CAS  CrossRef  PubMed  Google Scholar 

  • Dobs, A. S., Boccia, R. V., Croot, C. C., Gabrail, N. Y., Dalton, J. T., Hancock, M. L., Johnston, M. A., & Steiner, M. S. (2013). Effects of enobosarm on muscle wasting and physical function in patients with cancer: A double-blind, randomised controlled phase 2 trial. Lancet Oncology, 14, 335–345.

    CAS  CrossRef  PubMed  Google Scholar 

  • Dong, J., Sundell, M. B., Pupim, L. B., Wu, P. S., Shintani, A., & Ikizler, T. A. (2011). The effect of resistance exercise to augment long-term benefits of intradialytic oral nutritional supplementation in chronic hemodialysis patients. Journal of Renal Nutrition, 21, 149–159.

    CrossRef  PubMed  Google Scholar 

  • Dos Santos, M. R., Sayegh, A. L. C., Bacurau, A. V. N., Arap, M. A., Brum, P. C., Pereira, R. M. R., Takayama, L., Barretto, A. C. P., Negrao, C. E., & Alves, M. J. D. N. (2016). Effect of exercise training and testosterone replacement on skeletal muscle wasting in patients with heart failure with testosterone deficiency. Mayo Clinic Proceedings, 91, 575–586.

    CAS  CrossRef  PubMed  Google Scholar 

  • Dubois, V., Laurent, M., Boonen, S., Vanderschueren, D., & Claessens, F. (2012). Androgens and skeletal muscle: Cellular and molecular action mechanisms underlying the anabolic actions. Cellular and Molecular Life Sciences, 69, 1651–1667.

    CAS  CrossRef  PubMed  Google Scholar 

  • Ebner, N., Elsner, S., Springer, J., & Von Haehling, S. (2014). Molecular mechanisms and treatment targets of muscle wasting and cachexia in heart failure: An overview. Current Opinion in Supportive and Palliative Care, 8, 15–24.

    CrossRef  PubMed  Google Scholar 

  • Evans, W. J. (2010). Skeletal muscle loss: Cachexia, sarcopenia, and inactivity. The American Journal of Clinical Nutrition, 91, 1123S–1127S.

    CAS  CrossRef  PubMed  Google Scholar 

  • Fazio, S., Sabatini, D., Capaldo, B., Vigorito, C., Giordano, A., Guida, R., Pardo, F., Biondi, B., & Sacca, L. (1996). A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. New England Journal of Medicine, 334, 809–814.

    CAS  CrossRef  PubMed  Google Scholar 

  • Fearon, K. C. H., Barber, M. D., Moses, A. G., Ahmedzai, S. H., Taylor, G. S., Tisdale, M. J., & Murray, G. D. (2006). Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia. Journal of Clinical Oncology, 24, 3401–3407.

    CAS  CrossRef  PubMed  Google Scholar 

  • Fearon, K., Strasser, F., Anker, S. D., Bosaeus, I., Bruera, E., Fainsinger, R. L., Jatoi, A., Loprinzi, C., MacDonald, N., Mantovani, G., Davis, M., Muscaritoli, M., Ottery, F., Radbruch, L., Ravasco, P., Walsh, D., Wilcock, A., Kaasa, S., & Baracos, V. E. (2011). Definition and classification of cancer cachexia: An international consensus. Lancet Oncology, 12, 489–495.

    CrossRef  PubMed  Google Scholar 

  • Fenster, L. F. (1966). Nonefficacy of short-term anabolic steroid therapy in alcoholic liver disease. Annals of Internal Medicine, 65, 738.

    CAS  CrossRef  Google Scholar 

  • Ferrando, A. A., Sheffield-Moore, M., Paddon-Jones, D., Wolfe, R. R., & Urban, R. J. (2003). Differential anabolic effects of testosterone and amino acid feeding in older men. The Journal of Clinical Endocrinology and Metabolism, 88, 358–362.

    CAS  CrossRef  PubMed  Google Scholar 

  • Ferreira, I. M., Verreschi, I. T., Nery, L. E., Goldstein, R. S., Zamel, N., Brooks, D., & Jardim, J. R. (1998). The influence of 6 months of oral anabolic steroids on body mass and respiratory muscles in undernourished COPD patients. Chest, 114, 19–28.

    CAS  CrossRef  PubMed  Google Scholar 

  • Ferry, Noirez, Page, C. L., Salah, I. B., Daegelen, & Rieu. (1999). Effects of anabolic/androgenic steroids on regenerating skeletal muscles in the rat. Acta Physiologica Scandinavica, 166, 105–110.

    CAS  CrossRef  PubMed  Google Scholar 

  • Flynn, M. A., Weaver-Osterholtz, D., Sharpe-Timms, K. L., Allen, S., & Krause, G. (1999). Dehydroepiandrosterone replacement in aging humans. The Journal of Clinical Endocrinology and Metabolism, 84, 1527–1533.

    CAS  PubMed  Google Scholar 

  • Fouque, D., Kalantar-Zadeh, K., Kopple, J., Cano, N., Chauveau, P., Cuppari, L., Franch, H., Ghuarnieri, G., Ikizler, T. A., Kaysen, G., Lindholm, B., Massy, Z., Mitch, W., Pineda, E., Stenvinkel, P., Trevinho-Becerra, A., & Wanner, C. (2008). A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney International, 73, 391–398.

    CAS  CrossRef  PubMed  Google Scholar 

  • Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., McBurnie, M. A., & Cardiovascular Health Study Collaborative Research, G. (2001). Frailty in older adults: Evidence for a phenotype. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56, M146–M156.

    CAS  CrossRef  PubMed  Google Scholar 

  • Fulster, S., Tacke, M., Sandek, A., Ebner, N., Tschope, C., Doehner, W., Anker, S. D., & Von Haehling, S. (2013). Muscle wasting in patients with chronic heart failure: Results from the studies investigating co-morbidities aggravating heart failure (SICA-HF). European Heart Journal, 34, 512–519.

    CrossRef  CAS  PubMed  Google Scholar 

  • Gallagher, D., Visser, M., De Meersman, R. E., Sepulveda, D., Baumgartner, R. N., Pierson, R. N., Harris, T., & Heymsfield, S. B. (1997). Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity. Journal Applied Physiology (1985), 83, 229–239.

    CAS  CrossRef  Google Scholar 

  • Gallagher, D., Ruts, E., Visser, M., Heshka, S., Baumgartner, R. N., Wang, J., Pierson, R. N., Pi-Sunyer, F. X., & Heymsfield, S. B. (2000). Weight stability masks sarcopenia in elderly men and women. American Journal of Physiology. Endocrinology and Metabolism, 279, E366–E375.

    CAS  CrossRef  PubMed  Google Scholar 

  • Garcia, J. M., Li, H., Mann, D., Epner, D., Hayes, T. G., Marcelli, M., & Cunningham, G. R. (2006). Hypogonadism in male patients with cancer. Cancer, 106, 2583–2591.

    CAS  CrossRef  PubMed  Google Scholar 

  • Garcia, J. M., Boccia, R. V., Graham, C. D., Yan, Y., Duus, E. M., Allen, S., & Friend, J. (2015). Anamorelin for patients with cancer cachexia: An integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials. Lancet Oncology, 16, 108–116.

    CAS  CrossRef  PubMed  Google Scholar 

  • Gielen, S., Adams, V., Mobius-Winkler, S., Linke, A., Erbs, S., Yu, J. T., Kempf, W., Schubert, A., Schuler, G., & Hambrecht, R. (2003). Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology, 42, 861–868.

    CAS  CrossRef  PubMed  Google Scholar 

  • Glaser, R., & Dimitrakakis, C. (2013). Testosterone therapy in women: Myths and misconceptions. Maturitas, 74, 230–234.

    CAS  CrossRef  PubMed  Google Scholar 

  • Glass, D. J. (2005). Skeletal muscle hypertrophy and atrophy signaling pathways. The International Journal of Biochemistry & Cell Biology, 37, 1974–1984.

    CAS  CrossRef  Google Scholar 

  • Gluud, C. (1986). Testosterone treatment of men with alcoholic cirrhosis – a double-blind-study. Hepatology, 6, 807–813.

    CrossRef  Google Scholar 

  • Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., & Newman, A. B. (2006). The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61, 1059–1064.

    CrossRef  Google Scholar 

  • Gosker, H. R., Kubat, B., Schaart, G., Van Der Vusse, G. J., Wouters, E. F., & Schols, A. M. (2003). Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease. The European Respiratory Journal, 22, 280–285.

    CAS  CrossRef  PubMed  Google Scholar 

  • Grinspoon, S., Corcoran, C., Lee, K., Burrows, B., Hubbard, J., Katznelson, L., Walsh, M., Guccione, A., Cannan, J., Heller, H., Basgoz, N., & Klibanski, A. (1996). Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting. The Journal of Clinical Endocrinology and Metabolism, 81, 4051–4058.

    CAS  PubMed  Google Scholar 

  • Grobe, Y. G., Rodriguez, G. P., Ramos, M. H., Uribe, M., & Sanchez, N. M. (2010). Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens. Annals of Hepatology, 9, 402–409.

    Google Scholar 

  • Gross, D. N., Van Den Heuvel, A. P., & Birnbaum, M. J. (2008). The role of FoxO in the regulation of metabolism. Oncogene, 27, 2320–2336.

    CAS  CrossRef  PubMed  Google Scholar 

  • Grossmann, M., Hoermann, R., Gani, L., Chan, I., Cheung, A., Gow, P. J., Li, A., Zajac, J. D., & Angus, P. (2012). Low testosterone levels as an independent predictor of mortality in men with chronic liver disease. Clinical Endocrinology, 77, 323–328.

    CAS  CrossRef  PubMed  Google Scholar 

  • Grounds, M. D. (1987). Phagocytosis of necrotic muscle in muscle isografts is influenced by the strain, age, and sex of host mice. The Journal of Pathology, 153, 71–82.

    CAS  CrossRef  PubMed  Google Scholar 

  • Gulati, P., Gaspers, L. D., Dann, S. G., Joaquin, M., Nobukuni, T., Natt, F., Kozma, S. C., Thomas, A. P., & Thomas, G. (2008). Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metabolism, 7, 456–465.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Gungor, O., Kircelli, F., Carrero, J. J., Asci, G., Toz, H., Tatar, E., Hur, E., Sever, M. S., Arinsoy, T., & Ok, E. (2010). Endogenous testosterone and mortality in male hemodialysis patients: Is it the result of aging? Clinical Journal of the American Society of Nephrology, 5, 2018–2023.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Haizlip, K. M., Harrison, B. C., & Leinwand, L. A. (2015). Sex-based differences in skeletal muscle kinetics and fiber-type composition. Physiology (Bethesda), 30, 30–39.

    CAS  PubMed Central  Google Scholar 

  • Hanai, T., Shiraki, M., Nishimura, K., Ohnishi, S., Imai, K., Suetsugu, A., Takai, K., Shimizu, M., & Moriwaki, H. (2015). Sarcopenia impairs prognosis of patients with liver cirrhosis. Nutrition, 31, 193–199.

    CrossRef  PubMed  Google Scholar 

  • Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., blackman, M. R., & Baltimore Longitudinal Study of, A. (2001). Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. The Journal of Clinical Endocrinology and Metabolism, 86, 724–731.

    CAS  CrossRef  PubMed  Google Scholar 

  • Harrington, D., Chua, T. P., & Coats, A. J. S. (2000). The effect of salbutamol on skeletal muscle in chronic heart failure. International Journal of Cardiology, 73, 257–265.

    CAS  CrossRef  PubMed  Google Scholar 

  • Heimburger, O., Qureshi, A. R., Blaner, W. S., Berglund, L., & Stenvinkel, P. (2000). Hand-grip muscle strength, lean body mass, and plasma proteins as markers of nutritional status in patients with chronic renal failure close to start of dialysis therapy. American Journal of Kidney Diseases, 36, 1213–1225.

    CAS  CrossRef  PubMed  Google Scholar 

  • Herbst, K. L., & Bhasin, S. (2004). Testosterone action on skeletal muscle. Current Opinion in Clinical Nutrition and Metabolic Care, 7, 271–277.

    CAS  CrossRef  PubMed  Google Scholar 

  • Hetzler, K. L., Hardee, J. P., Lavoie, H. A., Murphy, E. A., & Carson, J. A. (2017). Ovarian function’s role during cancer cachexia progression in the female mouse. American Journal of Physiology. Endocrinology and Metabolism, 312, E447–E459.

    CrossRef  PubMed  Google Scholar 

  • Hong, D. S., Janku, F., Naing, A., Falchook, G. S., Piha-Paul, S., Wheler, J. J., Fu, S. Q., Tsimberidou, A. M., Stecher, M., Mohanty, P., Simard, J., & Kurzrock, R. (2015). Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer. Investigational New Drugs, 33, 621–631.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Hopkinson, N. S., Tennant, R. C., Dayer, M. J., Swallow, E. B., Hansel, T. T., Moxham, J., & Polkey, M. I. (2007). A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease. Respiratory Research, 8, 25.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Horstman, A. M., Dillon, E. L., Urban, R. J., & Sheffield-Moore, M. (2012). The role of androgens and estrogens on healthy aging and longevity. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 67, 1140–1152.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang, H., & Tindall, D. J. (2007). Dynamic FoxO transcription factors. Journal of Cell Science, 120, 2479–2487.

    CAS  CrossRef  PubMed  Google Scholar 

  • Iellamo, F., Volterrani, M., Caminiti, G., Karam, R., Massaro, R., Fini, M., Collins, P., & Rosano, G. M. C. (2010). Testosterone therapy in women with chronic heart failure a pilot double-blind, randomized, placebo-controlled study. Journal of the American College of Cardiology, 56, 1310–1316.

    CAS  CrossRef  PubMed  Google Scholar 

  • Iglesias, P., Diez, J. J., Fernandez-Reyes, M. J., Aguilera, A., Burgues, S., Martinez-Ara, J., Miguel, J. L., Gomez-Pan, A., & Selgas, R. (1998). Recombinant human growth hormone therapy in malnourished dialysis patients: A randomized controlled study. American Journal of Kidney Diseases, 32, 454–463.

    CAS  CrossRef  PubMed  Google Scholar 

  • Igwebuike, A., Irving, B. A., Bigelow, M. L., Short, K. R., McConnell, J. P., & Nair, K. S. (2008). Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women. The Journal of Clinical Endocrinology and Metabolism, 93, 534–538.

    CAS  CrossRef  PubMed  Google Scholar 

  • Ikizler, T. A., Pupim, L. B., Brouillette, J. R., Levenhagen, D. K., Farmer, K., Hakim, R. M., & Flakoll, P. J. (2002). Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation. American Journal of Physiology. Endocrinology and Metabolism, 282, E107–E116.

    CAS  CrossRef  PubMed  Google Scholar 

  • Isgaard, J., Bergh, C. H., Caidahl, K., Lomsky, M., Hjalmarson, A., & Bengtsson, B. A. (1998). A placebo-controlled study of growth hormone in patients with congestive heart failure. European Heart Journal, 19, 1704–1711.

    CAS  CrossRef  PubMed  Google Scholar 

  • Itoh, T., Nagaya, N., Yoshikawa, M., Fukuoka, A., Takenaka, H., Simizu, Y., Haruta, Y., Oya, H., Yamagishi, M., Hosoda, H., Kangawa, K., & Kimura, H. (2004). Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 170, 879–882.

    CrossRef  PubMed  Google Scholar 

  • Jang, S. W., Yang, S. J., Srinivasan, S., & Ye, K. (2007). Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. The Journal of Biological Chemistry, 282, 30836–30844.

    CAS  CrossRef  PubMed  Google Scholar 

  • Janssen, I., Heymsfield, S. B., Wang, Z. M., & Ross, R. (2000). Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. Journal Applied Physiology (1985), 89, 81–88.

    CAS  CrossRef  Google Scholar 

  • Janssen, I., Baumgartner, R. N., Ross, R., Rosenberg, I. H., & Roubenoff, R. (2004a). Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. American Journal of Epidemiology, 159, 413–421.

    CrossRef  PubMed  Google Scholar 

  • Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004b). The healthcare costs of sarcopenia in the United States. Journal of the American Geriatrics Society, 52, 80–85.

    CrossRef  PubMed  Google Scholar 

  • Jasuja, R., & Lebrasseur, N. K. (2014). Regenerating skeletal muscle in the face of aging and disease. American Journal of Physical Medicine & Rehabilitation, 93, S88–S96.

    CrossRef  Google Scholar 

  • Jedrzejuk, D., Medras, M., Milewicz, A., & Demissie, M. (2003). Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: Effects on fat distribution, insulin sensitivity and lipid metabolism. The Aging Male, 6, 151–156.

    CAS  CrossRef  PubMed  Google Scholar 

  • Johansen, K. L., Painter, P. L., Sakkas, G. K., Gordon, P., Doyle, J., & Shubert, T. (2006). Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: A randomized, controlled trial. Journal of the American Society of Nephrology, 17, 2307–2314.

    CAS  CrossRef  PubMed  Google Scholar 

  • Ju, C. R., & Chen, R. C. (2012). Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease. Respiratory Medicine, 106, 102–108.

    CrossRef  PubMed  Google Scholar 

  • Kaizu, Y., Ohkawa, S., Odamaki, M., Ikegaya, N., Hibi, I., Miyaji, K., & Kumagai, H. (2003). Association between inflammatory mediators and muscle mass in long-term hemodialysis patients. American Journal of Kidney Diseases, 42, 295–302.

    CAS  CrossRef  PubMed  Google Scholar 

  • Kamada, Y., Kiso, S., Yoshida, Y., Chatani, N., Kizu, T., Hamano, M., Tsubakio, M., Takemura, T., Ezaki, H., Hayashi, N., & Takehara, T. (2011). Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet. American Journal of Physiology. Gastrointestinal and Liver Physiology, 301, G1031–G1043.

    CAS  CrossRef  PubMed  Google Scholar 

  • Kamalakkannan, G., Petrilli, C. M., George, I., Lamanca, J., McLaughlin, B. T., Shane, E., Mancini, D. M., & Maybaum, S. (2008). Clenbuterol increases lean muscle mass but not endurance in patients with chronic heart failure. Journal of Heart and Lung Transplantation, 27, 457–461.

    CrossRef  PubMed  Google Scholar 

  • Kenny, A. M., Boxer, R. S., Kleppinger, A., Brindisi, J., Feinn, R., & Burleson, J. A. (2010). Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women. Journal of the American Geriatrics Society, 58, 1707–1714.

    CrossRef  PubMed  Google Scholar 

  • Khor, S. C., Abdul Karim, N., Ngah, W. Z., Yusof, Y. A., & Makpol, S. (2014). Vitamin E in sarcopenia: Current evidences on its role in prevention and treatment. Oxidative Medicine and Cellular Longevity, 2014, 914853.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Kopple, J. D., Wang, H. Y., Casaburi, R., Fournier, M., Lewis, M. I., Taylor, W., & Storer, T. W. (2007). Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle. Journal of the American Society of Nephrology, 18, 2975–2986.

    CAS  CrossRef  PubMed  Google Scholar 

  • Kovacheva, E. L., Hikim, A. P., Shen, R., Sinha, I., & Sinha-Hikim, I. (2010). Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology, 151, 628–638.

    CAS  CrossRef  PubMed  Google Scholar 

  • Krasnoff, J. B., Basaria, S., Pencina, M. J., Jasuja, G. K., Vasan, R. S., Ulloor, J., Zhang, A., Coviello, A., Kelly-Hayes, M., D’Agostino, R. B., Wolf, P. A., Bhasin, S., & Murabito, J. M. (2010). Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: The Framingham Offspring Study. The Journal of Clinical Endocrinology and Metabolism, 95, 2790–2799.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • La Colla, A., Pronsato, L., Milanesi, L., & Vasconsuelo, A. (2015). 17beta-estradiol and testosterone in sarcopenia: Role of satellite cells. Ageing Research Reviews, 24, 166–177.

    CAS  CrossRef  PubMed  Google Scholar 

  • Lagirand-Cantaloube, J., Offner, N., Csibi, A., Leibovitch, M. P., Batonnet-Pichon, S., Tintignac, L. A., Segura, C. T., & Leibovitch, S. A. (2008). The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy. The EMBO Journal, 27, 1266–1276.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Lagirand-Cantaloube, J., Cornille, K., Csibi, A., Batonnet-Pichon, S., Leibovitch, M. P., & Leibovitch, S. A. (2009). Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. PLoS One, 4, e4973.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  • Laviano, A., & Meguid, M. M. (1996). Nutritional issues in cancer management. Nutrition, 12, 358–371.

    CAS  CrossRef  PubMed  Google Scholar 

  • Lee, S. J., & McPherron, A. C. (2001). Regulation of myostatin activity and muscle growth. Proceedings of the National Academy of Sciences of the United States of America, 98, 9306–9311.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Legrain, S., Massien, C., Lahlou, N., Roger, M., Debuire, B., Diquet, B., Chatellier, G., Azizi, M., Faucounau, V., Porchet, H., Forette, F., & Baulieu, E. E. (2000). Dehydroepiandrosterone replacement administration: Pharmacokinetic and pharmacodynamic studies in healthy elderly subjects. The Journal of Clinical Endocrinology and Metabolism, 85, 3208–3217.

    CAS  PubMed  Google Scholar 

  • Lenk, K., Erbs, S., Hollriegel, R., Beck, E., Linke, A., Gielen, S., Mobius-Winkler, S., Sandri, M., Hambrecht, R., Schuler, G., & Adams, V. (2012). Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure. European Journal of Preventive Cardiology, 19, 404–411.

    CrossRef  PubMed  Google Scholar 

  • Lenk, K., Palus, S., Schur, R., Datta, R., Dong, J., Culler, M. D., Anker, S., Springer, J., Schuler, G., & Adams, V. (2013). Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model. Journal of Cachexia, Sarcopenia and Muscle, 4, 63–69.

    CrossRef  PubMed  Google Scholar 

  • Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990). Elevated circulating levels of tumor-necrosis-factor in severe chronic heart-failure. New England Journal of Medicine, 323, 236–241.

    CAS  CrossRef  PubMed  Google Scholar 

  • Levinson, B. G. J. (2012). Randomized study of the efficacy and safety of SUN11031 (synthetic human ghrelin) in cachexia associated with chronic obstructive pulmonary disease. e-SPEN Journal, 7, e171–e175.

    CrossRef  Google Scholar 

  • Lindberg, S., Jensen, J. S., Bjerre, M., Pedersen, S. H., Frystyk, J., Flyvbjerg, A., & Mogelvang, R. (2014). Cardio-adipose tissue cross-talk: Relationship between adiponectin, plasma pro brain natriuretic peptide and incident heart failure. European Journal of Heart Failure, 16, 633–638.

    CAS  CrossRef  PubMed  Google Scholar 

  • Lindle, R. S., Metter, E. J., Lynch, N. A., Fleg, J. L., Fozard, J. L., Tobin, J., Roy, T. A., & Hurley, B. F. (1997). Age and gender comparisons of muscle strength in 654 women and men aged 20–93 yr. Journal Applied Physiology (1985), 83, 1581–1587.

    CAS  CrossRef  Google Scholar 

  • Lund, L. H., Williams, J. J., Freda, P., Lamanca, J. J., Lejemtel, T. H., & Mancini, D. M. (2009). Ghrelin resistance occurs in severe heart failure and resolves after heart transplantation. European Journal of Heart Failure, 11, 789–794.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Lundholm, K., Gunnebo, L., Korner, U., Iresjo, B. M., Engstrom, C., Hyltander, A., Smedh, U., & Bosaeus, I. (2010). Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients a randomized double-blind study. Cancer, 116, 2044–2052.

    CAS  CrossRef  PubMed  Google Scholar 

  • Luo, F. M., Liu, X. J., Li, S. Q., Wang, Z. L., Liu, C. T., & Yuan, Y. M. (2005). Circulating ghrelin in patients with chronic obstructive pulmonary disease. Nutrition, 21, 793–798.

    CAS  CrossRef  PubMed  Google Scholar 

  • MacLean, H. E., Chiu, W. S., Notini, A. J., Axell, A. M., Davey, R. A., McManus, J. F., Ma, C., Plant, D. R., Lynch, G. S., & Zajac, J. D. (2008). Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. The FASEB Journal, 22, 2676–2689.

    CAS  CrossRef  PubMed  Google Scholar 

  • Malkin, C. J., Pugh, P. J., West, J. N., Van Beek, E., Jones, T. H., & Channer, K. S. (2006). Testosterone therapy in men with moderate severity heart failure: A double blind RCT. European Heart Journal, 27, 23–23.

    CrossRef  CAS  Google Scholar 

  • Marcen, R., Teruel, J. L., Delacal, M. A., Gamez, C., Caramelo, J., Herrero, J. A., Hernandez, E., Dearribas, G., Jarillo, M. D., Montoyo, C., Revuelta, K. L., Perez, R., Martinez, J., Miguel, J. L., Naya, M., Sanz, P., Sanchez, A., Caparros, L., Chacon, J. C., Paraiso, V., Oliet, A., Vigil, A., Sanz, R., Tornero, F., Lozano, L., Diaz, R., Vazquez, I., Ruiz, Lamas, S., Naranjo, J., & Hernando, P. (1997). The impact of malnutrition in morbidity and mortality in stable haemodialysis patients. Nephrology, Dialysis, Transplantation, 12, 2324–2331.

    CAS  CrossRef  PubMed  Google Scholar 

  • Mauras, N., Hayes, V., Welch, S., Rini, A., Helgeson, K., Dokler, M., Veldhuis, J. D., & Urban, R. J. (1998). Testosterone deficiency in young men: Marked alterations in whole body protein kinetics, strength, and adiposity. The Journal of Clinical Endocrinology and Metabolism, 83, 1886–1892.

    CAS  PubMed  Google Scholar 

  • Mcentegart, M. B., Awede, B., Petrie, M. C., Sattar, N., Dunn, F. G., MacFarlane, N. G., & McMurray, J. J. V. (2007). Increase in serum adiponectin concentration in patients with heart failure and cachexia: Relationship with leptin, other cytokines, and B-type natriuretic peptide. European Heart Journal, 28, 829–835.

    CAS  CrossRef  PubMed  Google Scholar 

  • Mckenzie, J., Fisher, B. M., Jaap, A. J., Stanley, A., Paterson, K., & Sattar, N. (2006). Effects of HRT on liver enzyme levels in women with type 2 diabetes: A randomized placebo-controlled trial. Clinical Endocrinology, 65, 40–44.

    CAS  CrossRef  PubMed  Google Scholar 

  • Mcmahon, C. D., Chai, R., Radley-Crabb, H. G., Watson, T., Matthews, K. G., Sheard, P. W., Soffe, Z., Grounds, M. D., & Shavlakadze, T. (2014). Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice. Scandinavian Journal of Medicine & Science in Sports, 24, e423–e435.

    CAS  CrossRef  Google Scholar 

  • Mehra, M. R., Lavie, C. J., Ventura, H. O., & Milani, R. V. (2006). Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure. Journal of Heart and Lung Transplantation, 25, 834–838.

    CrossRef  PubMed  Google Scholar 

  • Mendenhall, C. L., Anderson, S., Garcia-Pont, P., Goldberg, S., Kiernan, T., Seeff, L. B., Sorrell, M., Tamburro, C., Weesner, R., Zetterman, R., et al. (1984). Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. The New England Journal of Medicine, 311, 1464–1470.

    CAS  CrossRef  PubMed  Google Scholar 

  • Mendenhall, C. L., Moritz, T. E., Roselle, G. A., Morgan, T. R., Nemchausky, B. A., Tamburro, C. H., Schiff, E. R., McClain, C. J., Marsano, L. S., Allen, J. I., Samanta, A., Weesner, R. E., Henderson, W., Cartside, P., Chen, T. S., French, S. W., & Chedid, A. (1993). A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis – results of a department-of-veterans-affairs cooperative study. Hepatology, 17, 564–576.

    CAS  CrossRef  PubMed  Google Scholar 

  • Miki, K., Maekura, R., Nagaya, N., Nakazato, M., Kimura, H., Murakami, S., Ohnishi, S., Hiraga, T., Miki, M., Kitada, S., Yoshimura, K., Tateishi, Y., Arimura, Y., Matsumoto, N., Yoshikawa, M., Yamahara, K., & Kangawa, K. (2012). Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: A multicenter, randomized, double-blind, placebo-controlled trial. Plos One, 7, e35708.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Milanovic, Z., Pantelic, S., Trajkovic, N., Sporis, G., Kostic, R., & James, N. (2013). Age-related decrease in physical activity and functional fitness among elderly men and women. Clinical Interventions in Aging, 8, 549–556.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Mirdamadi, A., Garakyaraghi, M., Pourmoghaddas, A., Bahmani, A., Mahmoudi, H., & Gharipour, M. (2014). Beneficial effects of testosterone therapy on functional capacity, cardiovascular parameters, and quality of life in patients with congestive heart failure. Biomed Research International, 2014, 1–7.

    CrossRef  CAS  Google Scholar 

  • Mitch, W. E. (2007). Malnutrition is an unusual cause of decreased muscle mass in chronic kidney disease. Journal of Renal Nutrition, 17, 66–69.

    CrossRef  PubMed  Google Scholar 

  • Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012). Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review. Frontiers in Physiology, 3, 260.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Miyazaki, M., & Esser, K. A. (2009). Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals. Journal Applied Physiology (1985), 106, 1367–1373.

    CAS  CrossRef  Google Scholar 

  • Mondello, P., Mian, M., Aloisi, C., Fama, F., Mondello, S., & Pitini, V. (2015). Cancer cachexia syndrome: Pathogenesis, diagnosis, and new therapeutic options. Nutrition and Cancer-an International Journal, 67, 12–26.

    CAS  CrossRef  Google Scholar 

  • Montano-Loza, A. J. (2014). Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation. Liver Transplantation, 20, 1424–1424.

    CrossRef  PubMed  Google Scholar 

  • Mooradian, A. D., Morley, J. E., & Korenman, S. G. (1987). Biological actions of androgens. Endocrine Reviews, 8, 1–28.

    CAS  CrossRef  PubMed  Google Scholar 

  • Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998). The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clinical Endocrinology, 49, 421–432.

    CAS  CrossRef  PubMed  Google Scholar 

  • Moran, A. L., Nelson, S. A., Landisch, R. M., Warren, G. L., & Lowe, D. A. (2007). Estradiol replacement reverses ovariectomy-induced muscle contractile and myosin dysfunction in mature female mice. Journal Applied Physiology (1985), 102, 1387–1393.

    CAS  CrossRef  Google Scholar 

  • Mori, A., Nishino, T., Obata, Y., Nakazawa, M., Hirose, M., Yamashita, H., Uramatsu, T., Shinzato, K., & Kohno, S. (2013). The effect of active vitamin D administration on muscle mass in hemodialysis patients. Clinical Drug Investigation, 33, 837–846.

    CAS  CrossRef  PubMed  Google Scholar 

  • Morley, J. E. (2016). Pharmacologic options for the treatment of sarcopenia. Calcified Tissue International, 98, 319–333.

    CAS  CrossRef  PubMed  Google Scholar 

  • Morley, J. E., & Malmstrom, T. K. (2013). Frailty, sarcopenia, and hormones. Endocrinology and Metabolism Clinics of North America, 42, 391–405.

    CrossRef  PubMed  Google Scholar 

  • Morley, J. E., & Perry, H. M. (2003). Androgens and women at the menopause and beyond. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 58, M409–M416.

    CrossRef  Google Scholar 

  • Morley, J. E., Thomas, D. R., & Wilson, M. M. G. (2006). Cachexia: Pathophysiology and clinical relevance. American Journal of Clinical Nutrition, 83, 735–743.

    CAS  CrossRef  PubMed  Google Scholar 

  • Murdoch, D. R., Rooney, E., Dargie, H. J., Shapiro, D., Morton, J. J., & McMurray, J. J. V. (1999). Inappropriately low plasma leptin concentration in the cachexia associated with chronic heart failure. Heart, 82, 352–356.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Nagaya, N., Moriya, J., Yasumura, Y., Uematsu, M., Ono, F., Shimizu, W., Ueno, K., Kitakaze, M., Miyatake, K., & Kangawa, K. (2004). Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation, 110, 3674–3679.

    CAS  CrossRef  PubMed  Google Scholar 

  • Nagaya, N., Itoh, T., Murakami, S., Oya, H., Uematsu, M., Miyatake, K., & Kangawa, K. (2005). Treatment of cachexia with ghrelin in patients with COPD. Chest, 128, 1187–1193.

    CAS  CrossRef  PubMed  Google Scholar 

  • Nair, K. S., Rizza, R. A., O’Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., Cobelli, C., Toffolo, G., Dalla Man, C., Tindall, D. J., Melton, L. J., 3rd, Smith, G. E., Khosla, S., & Jensen, M. D. (2006). DHEA in elderly women and DHEA or testosterone in elderly men. The New England Journal of Medicine, 355, 1647–1659.

    CAS  CrossRef  PubMed  Google Scholar 

  • Nakae, J., Oki, M., & Cao, Y. (2008). The FoxO transcription factors and metabolic regulation. FEBS Letters, 582, 54–67.

    CAS  CrossRef  PubMed  Google Scholar 

  • Nakamura, N., Hara, T., Shibata, Y., Matsumoto, T., Nakamura, H., Ninomiya, S., Kito, Y., Kitagawa, J., Kanemura, N., Goto, N., Shiraki, M., Miyazaki, T., Takeuchi, T., Shimizu, M., & Tsurumi, H. (2015). Sarcopenia is an independent prognostic factor in male patients with diffuse large B-cell lymphoma. Annals of Hematology, 94, 2043–2053.

    CrossRef  PubMed  Google Scholar 

  • Narici, M. V., & Maffulli, N. (2010). Sarcopenia: Characteristics, mechanisms and functional significance. British Medical Bulletin, 95, 139–159.

    CAS  CrossRef  PubMed  Google Scholar 

  • Nass, R., Pezzoli, S. S., Oliveri, M. C., Patrie, J. T., Harrell, F. E., Jr., Clasey, J. L., Heymsfield, S. B., Bach, M. A., Vance, M. L., & Thorner, M. O. (2008). Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: A randomized trial. Annals of Internal Medicine, 149, 601–611.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Newman, A. B., & Brach, J. S. (2001). Gender gap in longevity and disability in older persons. Epidemiologic Reviews, 23, 343–350.

    CAS  CrossRef  PubMed  Google Scholar 

  • Orentreich, N., Brind, J. L., Vogelman, J. H., Andres, R., & Baldwin, H. (1992). Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. The Journal of Clinical Endocrinology and Metabolism, 75, 1002–1004.

    CAS  PubMed  Google Scholar 

  • Ortega, F., Toral, J., Cejudo, P., Villagomez, R., Sanchez, H., Castillo, J., & Montemayor, T. (2002). Comparison of effects of strength and endurance training in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 166, 669–674.

    CrossRef  PubMed  Google Scholar 

  • Osterziel, K. J., Strohm, O., Schuler, J., Friedrich, M., Hanlein, D., Willenbrock, R., Anker, S. D., Poole-Wilson, P. A., Ranke, M. B., & Dietz, R. (1998). Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy. Lancet, 351, 1233–1237.

    CAS  CrossRef  PubMed  Google Scholar 

  • Page, S. T., Amory, J. K., Bowman, F. D., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2005). Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. The Journal of Clinical Endocrinology and Metabolism, 90, 1502–1510.

    CAS  CrossRef  PubMed  Google Scholar 

  • Pahor, M., Guralnik, J. M., Ambrosius, W. T., Blair, S., Bonds, D. E., Church, T. S., Espeland, M. A., Fielding, R. A., Gill, T. M., Groessl, E. J., King, A. C., Kritchevsky, S. B., Manini, T. M., McDermott, M. M., Miller, M. E., Newman, A. B., Rejeski, W. J., Sink, K. M., Williamson, J. D., & Investigators, L. S. (2014). Effect of structured physical activity on prevention of major mobility disability in older adults: The LIFE study randomized clinical trial. JAMA, 311, 2387–2396.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Palus, S., Von Haehling, S., Doehner, W., Datta, R., Zhang, J., Dong, J. Z., Culler, M. D., Anker, S. D., & Springer, J. (2013). Effect of application route of the ghrelin analog BIM-28131 (RM-131) on body weight and body composition in a rat heart failure model. International Journal of Cardiology, 168, 2369–2374.

    CrossRef  PubMed  Google Scholar 

  • Papanicolaou, D. A., Ather, S. N., Zhu, H., Zhou, Y., Lutkiewicz, J., Scott, B. B., & Chandler, J. (2013). A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. The Journal of Nutrition, Health & Aging, 17, 533–543.

    CAS  CrossRef  Google Scholar 

  • Peng, S., Plank, L. D., McCall, J. L., Gillanders, L. K., McIlroy, K., & Gane, E. J. (2007). Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: A comprehensive study. American Journal of Clinical Nutrition, 85, 1257–1266.

    CAS  CrossRef  PubMed  Google Scholar 

  • Percheron, G., Hogrel, J. Y., Denot-Ledunois, S., Fayet, G., Forette, F., Baulieu, E. E., Fardeau, M., Marini, J. F., & Double-Blind Placebo-Controlled, T. (2003). Effect of 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area: A double-blind placebo-controlled trial. Archives of Internal Medicine, 163, 720–727.

    CAS  CrossRef  PubMed  Google Scholar 

  • Perrini, S., Laviola, L., Carreira, M. C., Cignarelli, A., Natalicchio, A., & Giorgino, F. (2010). The GH/IGF1 axis and signaling pathways in the muscle and bone: Mechanisms underlying age-related skeletal muscle wasting and osteoporosis. The Journal of Endocrinology, 205, 201–210.

    CAS  CrossRef  PubMed  Google Scholar 

  • Pineda-Juarez, J. A., Sanchez-Ortiz, N. A., Castillo-Martinez, L., Orea-Tejeda, A., Cervantes-Gaytan, R., Keirns-Davis, C., Perez-Ocampo, C., Quiroz-Bautista, K., Tenorio-Dupont, M., & Ronquillo-Martinez, A. (2016). Changes in body composition in heart failure patients after a resistance exercise program and branched chain amino acid supplementation. Clinical Nutrition, 35, 41–47.

    CAS  CrossRef  PubMed  Google Scholar 

  • Plank, L. D., Gane, E. J., Peng, S., Muthu, C., Mathur, S., Gillanders, L., McIlroy, K., Donaghy, A. J., & McCall, J. L. (2008). Nocturnal nutritional supplementation improves total body protein status of patients with liver cirrhosis: A randomized 12-month trial. Hepatology, 48, 557–566.

    CrossRef  PubMed  Google Scholar 

  • Plant, P. J., Brooks, D., Faughnan, M., Bayley, T., Bain, J., Singer, L., Correa, J., Pearce, D., Binnie, M., & Batt, J. (2010). Cellular markers of muscle atrophy in chronic obstructive pulmonary disease. American Journal of Respiratory Cell and Molecular Biology, 42, 461–471.

    CAS  CrossRef  PubMed  Google Scholar 

  • Plata-Salaman, C. (2001). Cytokines and feeding. International Journal of Obesity, 25, S48–S52.

    CAS  CrossRef  PubMed  Google Scholar 

  • Pollanen, E., Ronkainen, P. H., Horttanainen, M., Takala, T., Puolakka, J., Suominen, H., Sipila, S., & Kovanen, V. (2010). Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle. Growth Hormone & IGF Research, 20, 372–379.

    CrossRef  CAS  Google Scholar 

  • Pomies, P., Rodriguez, J., Blaquiere, M., Sedraoui, S., Gouzi, F., Carnac, G., Laoudj-Chenivesse, D., Mercier, J., Prefaut, C., & Hayot, M. (2015). Reduced myotube diameter, atrophic signalling and elevated oxidative stress in cultured satellite cells from COPD patients. Journal of Cellular and Molecular Medicine, 19, 175–186.

    CAS  CrossRef  PubMed  Google Scholar 

  • Powers, S. K., Wiggs, M. P., Duarte, J. A., Zergeroglu, A. M., & Demirel, H. A. (2012). Mitochondrial signaling contributes to disuse muscle atrophy. American Journal of Physiology. Endocrinology and Metabolism, 303, E31–E39.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Prado, C. M. M., Baracos, V. E., McCargar, L. J., Reiman, T., Mourtzakis, M., Tonkin, K., Mackey, J. R., Koski, S., Pituskin, E., & Sawyer, M. B. (2009). Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment. Clinical Cancer Research, 15, 2920–2926.

    CAS  CrossRef  PubMed  Google Scholar 

  • Pu, C. T., Johnson, M. T., Forman, D. E., Hausdorff, J. M., Roubenoff, R., Foldvari, M., Fielding, R. A., & Singh, M. A. F. (2001). Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure. Journal of Applied Physiology, 90, 2341–2350.

    CAS  CrossRef  PubMed  Google Scholar 

  • Pugh, P. J., Jones, R. D., West, J. N., Jones, T. H., & Channer, K. S. (2004). Testosterone treatment for men with chronic heart failure. Heart, 90, 446–447.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Puig-Vilanova, E., Rodriguez, D. A., Lloreta, J., Ausin, P., Pascual-Guardia, S., Broquetas, J., Roca, J., Gea, J., & Barreiro, E. (2015). Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer. Free Radical Biology & Medicine, 79, 91–108.

    CAS  CrossRef  Google Scholar 

  • Puliyel, M. M., Vyas, G. P., & Mehta, G. S. (1977). Testosterone in management of cirrhosis of liver – controlled-study. Australian and New Zealand Journal of Medicine, 7, 596–599.

    CrossRef  Google Scholar 

  • Quinten, C., Coens, C., Mauer, M., Comte, S., Sprangers, M. A. G., Cleeland, C., Osoba, D., Bjordal, K., Bottomley, A., & GRP, E. C. (2009). Baseline quality of life as a prognostic indicator of survival: A meta-analysis of individual patient data from EORTC clinical trials. Lancet Oncology, 10, 865–871.

    CrossRef  PubMed  Google Scholar 

  • Qureshi, A. R., Alvestrand, A., Danielsson, A., Divino-Filho, J. C., Gutierrez, A., Lindholm, B., & Bergstrom, J. (1998). Factors predicting malnutrition in hemodialysis patients: A cross-sectional study. Kidney International, 53, 773–782.

    CAS  CrossRef  PubMed  Google Scholar 

  • Raj, D. S. C., Zager, P., Shah, V. O., Dominic, E. A., Adeniyi, O., Blandon, P., Wolfe, R., & Ferrando, A. (2004). Protein turnover and amino acid transport kinetics in end-stage renal disease. American Journal of Physiology. Endocrinology and Metabolism, 286, E136–E143.

    CAS  CrossRef  PubMed  Google Scholar 

  • Rauchhaus, M., Doehner, W., Francis, D. P., Davos, C., Kemp, M., Liebenthal, C., Niebauer, J., Hooper, J., Volk, H. D., Coats, A. J. S., & Anker, S. D. (2000). Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation, 102, 3060–3067.

    CAS  CrossRef  PubMed  Google Scholar 

  • Reid, J., Noble, H., Slee, A., Davenport, A., Farrington, K., Fouque, D., Kalantar-Zadeh, K., Porter, S., Seres, D., Witham, M., & Maxwell, A. (2016). Distinguishing between cachexia, sarcopenia and protein energy wasting in end-stage renal disease patients on dialysis. Palliative Medical Hospital Care Open Journal, 2, e11–e13.

    CrossRef  Google Scholar 

  • Rigas, J. R., Schuster, M., Orlov, S. V., Milovanovic, B., Prabhash, K., Smith, J. T., & GRP, A. S. (2010). Efect of ALD518, a humanized anti-IL-6 antibody, on lean body mass loss and symptoms in patients with advanced non-small cell lung cancer (NSCLC): Results of a phase II randomized double-blind safety and efficacy trial. Journal of Clinical Oncology, 28, 7622.

    CrossRef  Google Scholar 

  • Ronkainen, P. H., Kovanen, V., Alen, M., Pollanen, E., Palonen, E. M., Ankarberg-Lindgren, C., Hamalainen, E., Turpeinen, U., Kujala, U. M., Puolakka, J., Kaprio, J., & Sipila, S. (2009). Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: A study with monozygotic twin pairs. Journal of Applied Physiology, 107, 25–33.

    CAS  CrossRef  PubMed  Google Scholar 

  • Rossignol, P., Masson, S., Barlera, S., Girerd, N., Castelnovo, A., Zannad, F., Clemenza, F., Tognoni, G., Anand, I. S., Cohn, J. N., Anker, S. D., Tavazzi, L., Latini, R., Investigator, G.-H, & Investigator, V.-H. (2015). Loss in body weight is an independent prognostic factor for mortality in chronic heart failure: Insights from the GISSI-HF and Val-HeFT trials. European Journal of Heart Failure, 17, 424–433.

    CrossRef  PubMed  Google Scholar 

  • Rossouw, J. E., Anderson, G. L., Prentice, R. L., Lacroix, A. Z., Kooperberg, C., Stefanick, M. L., Jackson, R. D., Beresford, S. A. A., Howard, B. V., Johnson, K. C., Kotchen, J. M., & Ockene, J. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women – principal results from the Women’s Health Initiative randomized controlled trial. JAMA-Journal of the American Medical Association, 288, 321–333.

    CAS  CrossRef  Google Scholar 

  • Roth, S. M., Martel, G. F., Ivey, F. M., Lemmer, J. T., Metter, E. J., Hurley, B. F., & Rogers, M. A. (2000). High-volume, heavy-resistance strength training and muscle damage in young and older women. Journal Applied Physiology (1985), 88, 1112–1118.

    CAS  CrossRef  Google Scholar 

  • Rozentryt, P., Von Haehling, S., Lainscak, M., Nowak, J. U., Kalantar-Zadeh, K., Polonski, L., & Anker, S. D. (2010). The effects of a high-caloric protein-rich oral nutritional supplement in patients with chronic heart failure and cachexia on quality of life, body composition, and inflammation markers: A randomized, double-blind pilot study. Journal of Cachexia, Sarcopenia and Muscle, 1, 35–42.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., Schlenker, R. A., Cohn, L., Rudman, I. W., & Mattson, D. E. (1990). Effects of human growth hormone in men over 60 years old. The New England Journal of Medicine, 323, 1–6.

    CAS  CrossRef  PubMed  Google Scholar 

  • Rutten, E. P. A., Franssen, F. M. E., Engelen, M. P. K. J., Wouters, E. F. M., Deutz, N. E. P., & Schols, A. M. W. J. (2006). Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease. American Journal of Clinical Nutrition, 83, 829–834.

    CAS  CrossRef  PubMed  Google Scholar 

  • Sacheck, J. M., Hyatt, J. P., Raffaello, A., Jagoe, R. T., Roy, R. R., Edgerton, V. R., Lecker, S. H., & Goldberg, A. L. (2007). Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. The FASEB Journal, 21, 140–155.

    CAS  CrossRef  PubMed  Google Scholar 

  • Salih, D. A., & Brunet, A. (2008). FoxO transcription factors in the maintenance of cellular homeostasis during aging. Current Opinion in Cell Biology, 20, 126–136.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Samaras, N., Samaras, D., Frangos, E., Forster, A., & Philippe, J. (2013). A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: Is treatment beneficial? Rejuvenation Research, 16, 285–294.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Sanchez-Lara, K., Turcott, J. G., Juarez-Hernandez, E., Nunez-Valencia, C., Villanueva, G., Guevara, P., De La Torre-Vallejo, M., Mohar, A., & Arrieta, O. (2014). Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: Randomised trial. Clinical Nutrition, 33, 1017–1023.

    CAS  CrossRef  PubMed  Google Scholar 

  • Sandri, M. (2008). Signaling in muscle atrophy and hypertrophy. Physiology (Bethesda), 23, 160–170.

    CAS  Google Scholar 

  • Schols, A. M. W. J., Soeters, P. B., Mostert, R., Pluymers, R. J., & Wouters, E. F. M. (1995). Physiological-effects of nutritional support and anabolic-steroids in patients with chronic obstructive pulmonary-disease – a placebo-controlled randomized trial. American Journal of Respiratory and Critical Care Medicine, 152, 1268–1274.

    CAS  CrossRef  PubMed  Google Scholar 

  • Sergi, G., Coin, A., Marin, S., Vianello, A., Manzan, A., Peruzza, S., Inelmen, E. M., Busetto, L., Mulone, S., & Enzi, G. (2006). Body composition and resting energy expenditure in elderly mate patients with chronic obstructive pulmonary disease. Respiratory Medicine, 100, 1918–1924.

    CrossRef  PubMed  Google Scholar 

  • Serra-Prat, M., Papiol, M., Monteis, R., Palomera, E., & Cabre, M. (2015). Relationship between plasma ghrelin levels and sarcopenia in elderly subjects: A cross-sectional study. The Journal of Nutrition, Health & Aging, 19, 669–672.

    CAS  CrossRef  Google Scholar 

  • Sharma, S., Arneja, A., McLean, L., Duerksen, D., Leslie, W., Sciberras, D., & Lertzman, M. (2008). Anabolic steroids in COPD: A review and preliminary results of a randomized trial. Chronic Respiratory Disease, 5, 169–176.

    CAS  CrossRef  PubMed  Google Scholar 

  • Simons, J. P. F. H. A., Schols, A. M. W. J., Buurman, W. A., & Wouters, E. F. M. (1999). Weight loss and low body cell mass in males with lung cancer: Relationship with systemic inflammation, acute-phase response, resting energy expenditure, and catabolic and anabolic hormones. Clinical Science, 97, 215–223.

    CAS  CrossRef  PubMed  Google Scholar 

  • Sinclair, M., Gow, P. J., Grossmann, M., & Angus, P. W. (2016a). Review article: Sarcopenia in cirrhosis – aetiology, implications and potential therapeutic interventions. Alimentary Pharmacology & Therapeutics, 43, 765–777.

    CAS  CrossRef  Google Scholar 

  • Sinclair, M., Grossmann, M., Angus, P. W., Hoermann, R., Hey, P., Scodellaro, T., & Gow, P. J. (2016b). Low testosterone as a better predictor of mortality than sarcopenia in men with advanced liver disease. Journal of Gastroenterology and Hepatology, 31, 661–667.

    CAS  CrossRef  PubMed  Google Scholar 

  • Sinha-Hikim, I., Arver, S., Beall, G., Shen, R., Guerrero, M., Sattler, F., Shikuma, C., Nelson, J. C., Landgren, B. M., Mazer, N. A., & Bhasin, S. (1998). The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. The Journal of Clinical Endocrinology and Metabolism, 83, 1312–1318.

    CAS  PubMed  Google Scholar 

  • Sinha-Hikim, I., Taylor, W. E., Gonzalez-Cadavid, N. F., Zheng, W., & Bhasin, S. (2004). Androgen receptor in human skeletal muscle and cultured muscle satellite cells: Up-regulation by androgen treatment. The Journal of Clinical Endocrinology and Metabolism, 89, 5245–5255.

    CAS  CrossRef  PubMed  Google Scholar 

  • Sipila, S., Taaffe, D. R., Cheng, S., Puolakka, J., Toivanen, J., & Suominen, H. (2001). Effects of hormone replacement therapy and high-impact physical exercise on skeletal muscle in post-menopausal women: A randomized placebo-controlled study. Clinical Science (London, England), 101, 147–157.

    CAS  CrossRef  Google Scholar 

  • Sipila, S., Narici, M., Kjaer, M., Pollanen, E., Atkinson, R. A., Hansen, M., & Kovanen, V. (2013). Sex hormones and skeletal muscle weakness. Biogerontology, 14, 231–245.

    CrossRef  CAS  PubMed  Google Scholar 

  • Snyder, P. J., Peachey, H., Hannoush, P., Berlin, J. A., Loh, L., Lenrow, D. A., Holmes, J. H., Dlewati, A., Santanna, J., Rosen, C. J., & Strom, B. L. (1999). Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. The Journal of Clinical Endocrinology and Metabolism, 84, 2647–2653.

    CAS  PubMed  Google Scholar 

  • Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., Ensrud, K. E., Lewis, C. E., Farrar, J. T., Cella, D., Rosen, R. C., Pahor, M., Crandall, J. P., Molitch, M. E., Cifelli, D., Dougar, D., Fluharty, L., Resnick, S. M., Storer, T. W., Anton, S., Basaria, S., Diem, S. J., Hou, X., Mohler, E. R., 3rd, Parsons, J. K., Wenger, N. K., Zeldow, B., Landis, J. R., EELLENBERG, S. S., & Testosterone Trials, I. (2016). Effects of testosterone treatment in older men. The New England Journal of Medicine, 374, 611–624.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Sorensen, M. B., Rosenfalck, A. M., Hojgaard, L., & Ottesen, B. (2001). Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy. Obesity Research, 9, 622–626.

    CAS  CrossRef  PubMed  Google Scholar 

  • Stenvinkel, P., Barany, P., Chung, S. H., Lindholm, B., & Heimburger, O. (2002). A comparative analysis of nutritional parameters as predictors of outcome in male and female ESRD patients. Nephrology, Dialysis, Transplantation, 17, 1266–1274.

    CrossRef  PubMed  Google Scholar 

  • Stephens, N. A., Gray, C., MacDonald, A. J., Tan, B. H., Gallagher, I. J., Skipworth, R. J. E., Ross, J. A., Fearon, K. C. H., & Greig, C. A. (2012). Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function. Clinical Nutrition, 31, 499–505.

    CrossRef  PubMed  Google Scholar 

  • Stitt, T. N., Drujan, D., Clarke, B. A., Panaro, F., Timofeyva, Y., Kline, W. O., Gonzalez, M., Yancopoulos, G. D., & Glass, D. J. (2004). The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Molecular Cell, 14, 395–403.

    CAS  CrossRef  PubMed  Google Scholar 

  • Stout, M., Tew, G. A., Doll, H., Zwierska, I., Woodroofe, N., Channer, K. S., & Saxton, J. M. (2012). Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: A double-blind randomized controlled feasibility study. American Heart Journal, 164, 893–901.

    CAS  CrossRef  PubMed  Google Scholar 

  • Straight, C. R., Brady, A. O., & Evans, E. (2015). Sex-specific relationships of physical activity, body composition, and muscle quality with lower-extremity physical function in older men and women. Menopause, 22, 297–303.

    CrossRef  PubMed  Google Scholar 

  • Strasser, F., Palmer, J. L., Schover, L. R., Yusuf, S. W., Pisters, K., Vassilopoulou-Sellin, R., Degracia, B., Willey, J. S., & Bruera, E. (2006). The impact of hypogonadism and autonomic dysfunction on fatigue, emotional function, and sexual desire in male patients with advanced cancer: A pilot study. Cancer, 107, 2949–2957.

    CrossRef  PubMed  Google Scholar 

  • Stratton, R. J., Bircher, G., Fouque, D., Stenvinkel, P., De Mutsert, R., Engfer, M., & Elia, M. (2005). Multinutrient oral supplements and tube feeding in maintenance dialysis: A systematic review and meta-analysis. American Journal of Kidney Diseases, 46, 387–405.

    CAS  CrossRef  PubMed  Google Scholar 

  • Sun, L. J., Sun, Y. N., Chen, S. J., Liu, S., & Jiang, G. R. (2017). Resveratrol attenuates skeletal muscle atrophy induced by chronic kidney disease via MuRF1 signaling pathway. Biochemical and Biophysical Research Communications, 487, 83–89.

    CAS  CrossRef  PubMed  Google Scholar 

  • Supasyndh, O., Satirapoj, B., Aramwit, P., Viroonudomphol, D., Chaiprasert, A., Thanachatwej, V., Vanichakarn, S., & Kopple, J. D. (2013). Effect of oral anabolic steroid on muscle strength and muscle growth in hemodialysis patients. Clinical Journal of the American Society of Nephrology, 8, 271–279.

    CAS  CrossRef  PubMed  Google Scholar 

  • Svartberg, J., Aasebo, U., Hjalmarsen, A., Sundsfjord, J., & Jorde, R. (2004). Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial. Respiratory Medicine, 98, 906–913.

    CAS  CrossRef  PubMed  Google Scholar 

  • Szabo, T., Scherbakov, N., Sandek, A., Kung, T., Von Haehling, S., Lainscak, M., Jankowska, E. A., Rudovich, N., Anker, S. D., Frystyk, J., Flyvbjerg, A., Pfeiffer, A. F. H., & Doehner, W. (2014). Plasma adiponectin in heart failure with and without cachexia: Catabolic signal linking catabolism, symptomatic status, and prognosis. Nutrition, Metabolism, and Cardiovascular Diseases, 24, 50–56.

    CAS  CrossRef  PubMed  Google Scholar 

  • Taira, A. V., Merrick, G. S., Galbreath, R. W., Butler, W. M., Wallner, K. E., Allen, Z. A., Lief, J. H., & Adamovich, E. (2009). Pretreatment serum testosterone and androgen deprivation: Effect on disease recurrence and overall survival in prostate cancer patients treated with brachytherapy. International Journal of Radiation Oncology, Biology, Physics, 74, 1143–1149.

    CAS  CrossRef  PubMed  Google Scholar 

  • Tandon, P., Ney, M., Irwin, I., Ma, M. M., Gramlich, L., Bain, V. G., Esfandiari, N., Baracos, V., Montano-Loza, A. J., & Myers, R. P. (2012). Severe muscle depletion in patients on the liver transplant wait list: Its prevalence and independent prognostic value. Liver Transplantation, 18, 1209–1216.

    CrossRef  PubMed  Google Scholar 

  • Teixeira, P. J., Going, S. B., Houtkooper, L. B., Metcalfe, L. L., Blew, R. M., Flint-Wagner, H. G., Cussler, E. C., Sardinha, L. B., & Lohman, T. G. (2003). Resistance training in postmenopausal women with and without hormone therapy. Medicine and Science in Sports and Exercise, 35, 555–562.

    CrossRef  PubMed  Google Scholar 

  • Temel, J. S., Abernethy, A. P., Currow, D. C., Friend, J., Duus, E. M., Yan, Y., & Fearon, K. C. (2016). Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): Results from two randomised, double-blind, phase 3 trials. Lancet Oncology, 17, 519–531.

    CAS  CrossRef  PubMed  Google Scholar 

  • Theriault, M. E., Pare, M. E., Maltais, F., & Debigare, R. (2012). Satellite cells senescence in limb muscle of severe patients with COPD. Plos One, 7, e39124.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Thompson, L. V. (2009). Age-related muscle dysfunction. Experimental Gerontology, 44, 106–111.

    CAS  CrossRef  PubMed  Google Scholar 

  • Toma, M., McAlister, F. A., Coglianese, E. E., Vidi, V., Vasaiwala, S., Bakal, J. A., Armstrong, P. W., & Ezekowitz, J. A. (2012). Testosterone supplementation in heart failure a meta-analysis. Circulation. Heart Failure, 5, 315–321.

    CAS  CrossRef  PubMed  Google Scholar 

  • Traish, A. M., Kang, H. P., Saad, F., & Guay, A. T. (2011). Dehydroepiandrosterone (DHEA) – a precursor steroid or an active hormone in human physiology. The Journal of Sexual Medicine, 8, 2960–2982. quiz 2983.

    CAS  CrossRef  PubMed  Google Scholar 

  • Tseng, L. A., Delmonico, M. J., Visser, M., Boudreau, R. M., Goodpaster, B. H., Schwartz, A. V., Simonsick, E. M., Satterfield, S., Harris, T., & Newman, A. B. (2014). Body composition explains sex differential in physical performance among older adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69, 93–100.

    CrossRef  PubMed  Google Scholar 

  • Turola, E., Petta, S., Vanni, E., Milosa, F., Valenti, L., Critelli, R., Miele, L., Maccio, L., Calvaruso, V., Fracanzani, A. L., Bianchini, M., Raos, N., Bugianesi, E., Mercorella, S., Di Giovanni, M., Craxi, A., Fargion, S., Grieco, A., Camma, C., Cotelli, F., & Villa, E. (2015). Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis. Disease Models & Mechanisms, 8, 1037–1046.

    CAS  CrossRef  Google Scholar 

  • Utech, A. E., Tadros, E. M., Hayes, T. G., & Garcia, J. M. (2012). Predicting survival in cancer patients: The role of cachexia and hormonal, nutritional and inflammatory markers. Journal of Cachexia, Sarcopenia and Muscle, 3, 245–251.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Uzum, A. K., Aydin, M. M., Tutuncu, Y., Omer, B., Kiyan, E., & Alagol, F. (2014). Serum ghrelin and adiponectin levels are increased but serum leptin level is unchanged in low weight chronic obstructive pulmonary disease patients. European Journal of Internal Medicine, 25, 364–369.

    CAS  CrossRef  PubMed  Google Scholar 

  • Valentova, M., Von Haehling, S., Bauditz, J., Doehner, W., Ebner, N., Bekfani, T., Elsner, S., Sliziuk, V., Scherbakov, N., Murin, J., Anker, S. D., & Sandek, A. (2016). Intestinal congestion and right ventricular dysfunction: A link with appetite loss, inflammation, and cachexia in chronic heart failure. European Heart Journal, 37, 1684–1691.

    CrossRef  PubMed  Google Scholar 

  • Van Den Beld, A. W., De Jong, F. H., Grobbee, D. E., Pols, H. A., & Lamberts, S. W. (2000). Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. The Journal of Clinical Endocrinology and Metabolism, 85, 3276–3282.

    CAS  PubMed  Google Scholar 

  • Van Den Borst, B., Gosker, H. R., Koster, A., Yu, B., Kritchevsky, S. B., Liu, Y., Meibohm, B., Rice, T. B., Shlipak, M., Yende, S., Harris, T. B., Schols, A. M., Health, A, & Body Composition, S. (2012). The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease. American Journal of Clinical Nutrition, 96, 516–526.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Vasconsuelo, A., Pronsato, L., Ronda, A. C., Boland, R., & Milanesi, L. (2011). Role of 17beta-estradiol and testosterone in apoptosis. Steroids, 76, 1223–1231.

    CAS  CrossRef  PubMed  Google Scholar 

  • Velema, M. S., Kwa, B. H., & De Ronde, W. (2012). Should androgenic anabolic steroids be considered in the treatment regime of selected chronic obstructive pulmonary disease patients? Current Opinion in Pulmonary Medicine, 18, 118–124.

    CAS  CrossRef  PubMed  Google Scholar 

  • Vescovo, G., Volterrani, M., Zennaro, R., Sandri, M., Ceconi, C., Lorusso, R., Ferrari, R., Ambrosio, G. B., & Dalla Libera, L. (2000). Apoptosis in the skeletal muscle of patients with heart failure: Investigation of clinical and biochemical changes. Heart, 84, 431–437.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Vestbo, J., Prescott, E., Almdal, T., Dahl, M., Nordestgaard, B. G., Andersen, T., Sorensen, T. I. A., & Lange, P. (2006). Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample – findings from the Copenhagen City Heart Study. American Journal of Respiratory and Critical Care Medicine, 173, 79–83.

    PubMed  Google Scholar 

  • Villareal, D. T., & Holloszy, J. O. (2004). Effect of DHEA on abdominal fat and insulin action in elderly women and men: A randomized controlled trial. JAMA, 292, 2243–2248.

    CAS  CrossRef  PubMed  Google Scholar 

  • Vivodtzev, I., Pepin, J. L., Vottero, G., Mayer, V., Porsin, B., Levy, P., & Wuyam, B. (2006). Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical stimulation in severely deconditioned and malnourished COPD. Chest, 129, 1540–1548.

    CrossRef  PubMed  Google Scholar 

  • Vivodtzev, I., Debigare, R., Gagnon, P., Mainguy, V., Saey, D., Dube, A., Pare, M. E., Belanger, M., & Maltais, F. (2012). Functional and muscular effects of neuromuscular electrical stimulation in patients with severe COPD a randomized clinical trial. Chest, 141, 716–725.

    CrossRef  PubMed  Google Scholar 

  • Vogiatzis, I., Stratakos, G., Simoes, D. C., Terzis, G., Georgiadou, O., Roussos, C., & Zakynthinos, S. (2007). Effects of rehabilitative exercise on peripheral muscle TNFalpha, IL-6, IGF-I and MyoD expression in patients with COPD. Thorax, 62, 950–956.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Von Haehling, S. (2015). The wasting continuum in heart failure: From sarcopenia to cachexia. Proceedings of the Nutrition Society, 74, 367–377.

    CrossRef  Google Scholar 

  • Von Haehling, S., Morley, J. E., & Anker, S. D. (2010). An overview of sarcopenia: Facts and numbers on prevalence and clinical impact. Journal of Cachexia, Sarcopenia and Muscle, 1, 129–133.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Vonbank, K., Strasser, B., Mondrzyk, J., Marzluf, B. A., Richter, B., Losch, S., Nell, H., Petkov, V., & Haber, P. (2012). Strength training increases maximum working capacity in patients with COPD – randomized clinical trial comparing three training modalities. Respiratory Medicine, 106, 557–563.

    CrossRef  PubMed  Google Scholar 

  • Watson, E. L., Greening, N. J., Viana, J. L., Aulakh, J., Bodicoat, D. H., Barratt, J., Feehally, J., & Smith, A. C. (2015). Progressive resistance exercise training in CKD: A feasibility study. American Journal of Kidney Diseases, 66, 249–257.

    CrossRef  PubMed  Google Scholar 

  • Welch, A. A. (2014). Nutritional influences on age-related skeletal muscle loss. The Proceedings of the Nutrition Society, 73, 16–33.

    CAS  CrossRef  PubMed  Google Scholar 

  • Wells, R. (1960). Prednisolone and testosterone propionate in cirrhosis of the liver – a controlled trial. Lancet, 2, 1416–1419.

    CAS  CrossRef  PubMed  Google Scholar 

  • White, H. K., Petrie, C. D., Landschulz, W., Maclean, D., Taylor, A., Lyles, K., Wei, J. Y., Hoffman, A. R., Salvatori, R., Ettinger, M. P., Morey, M. C., Blackman, M. R., Merriam, G. R., & Capromorelin Study, G. (2009). Effects of an oral growth hormone secretagogue in older adults. The Journal of Clinical Endocrinology and Metabolism, 94, 1198–1206.

    CAS  CrossRef  PubMed  Google Scholar 

  • White, J. P., Baynes, J. W., Welle, S. L., Kostek, M. C., Matesic, L. E., Sato, S., & Carson, J. A. (2011). The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. PLoS One, 6, e24650.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Williamson, D. L., Raue, U., Slivka, D. R., & Trappe, S. (2010). Resistance exercise, skeletal muscle FOXO3A, and 85-year-old women. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 65, 335–343.

    CrossRef  CAS  PubMed  Google Scholar 

  • Wolf, I., Sadetzki, S., Kanety, H., Kundel, Y., Pariente, C., Epstein, N., Oberman, B., Catane, R., Kaufman, B., & Shimon, I. (2006). Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients. Cancer, 106, 966–973.

    CAS  CrossRef  PubMed  Google Scholar 

  • Wolfe, R., Ferrando, A., Sheffield-Moore, M., & Urban, R. (2000). Testosterone and muscle protein metabolism. Mayo Clinic Proceedings, 75(Suppl), S55–S59. discussion S59–60.

    CAS  PubMed  Google Scholar 

  • Yeh, S. S., Deguzman, B., Kramer, T., & Group, M. S. (2002). Reversal of COPD-associated weight loss using the anabolic agent oxandrolone. Chest, 122, 421–428.

    CAS  CrossRef  PubMed  Google Scholar 

  • Yende, S., Waterer, G. W., Tolley, E. A., Newman, A. B., Bauer, D. C., Taaffe, D. R., Jensen, R., Crapo, R., Rubin, S., Nevitt, M., Simonsick, E. M., Satterfield, S., Harris, T., & Kritchevsky, S. B. (2006). Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax, 61, 10–16.

    CAS  CrossRef  PubMed  Google Scholar 

  • Zambom-Ferraresi, F., Cebollero, P., Gorostiaga, E. M., Hernandez, M., Hueto, J., Cascante, J., Rezusta, L., Val, L., & Anton, M. M. (2015). Effects of combined resistance and endurance training versus resistance training alone on strength, exercise capacity, and quality of life in patients with COPD. Journal of Cardiopulmonary Rehabilitation and Prevention, 35, 446–453.

    CrossRef  PubMed  Google Scholar 

  • Zamboni, M., Zoico, E., Scartezzini, T., Mazzali, G., Tosoni, P., Zivelonghi, A., Gallagher, D., De Pergola, G., Di Francesco, V., & Bosello, O. (2003). Body composition changes in stable-weight elderly subjects: The effect of sex. Aging Clinical and Experimental Research, 15, 321–327.

    CrossRef  PubMed  Google Scholar 

  • Zanotti, E., Felicetti, G., Maini, M., & Fracchia, C. (2003). Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation – effect of electrical stimulation. Chest, 124, 292–296.

    CrossRef  PubMed  Google Scholar 

  • Zietz, B., Lock, G., Plach, B., Drobnik, W., Grossmann, J., Scholmerich, J., & Straub, R. H. (2003). Dysfunction of the hypothalamic-pituitary-glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis. European Journal of Gastroenterology & Hepatology, 15, 495–501.

    CAS  Google Scholar 

  • Zumoff, B., Strain, G. W., Miller, L. K., & Rosner, W. (1995). Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. The Journal of Clinical Endocrinology and Metabolism, 80, 1429–1430.

    CAS  PubMed  Google Scholar 

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Anderson, L.J., Liu, H., Garcia, J.M. (2017). Sex Differences in Muscle Wasting. In: Mauvais-Jarvis, F. (eds) Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity. Advances in Experimental Medicine and Biology, vol 1043. Springer, Cham. https://doi.org/10.1007/978-3-319-70178-3_9

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