The cell niches reproducing surface structure

  • Roman MajorEmail author
  • Klaudia Trembecka-Wojciga
  • Jürgen Markus Lackner
  • Bogusław Major
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 623)


The future and the development of science is therefore seen in interdisciplinary areas such as biomedical engineering. Self-assembled structures, similar to stem cell niches would inhibit fast division process and subsequently capture the stem cells from the blood flow. By means of surface topography and the stiffness as well as microstructure progenitor cells should be differentiated towards the formation of endothelial cells monolayer which effectively will inhibit activation of the coagulation cascade. The idea of the material surface development met the interest of the clinical institutions, which support the development of science in this area and are waiting for scientific solutions that could contribute to the development of heart assist systems. This would improve the effciency of the treatment of patients with myocardial failure, supported with artificial heart assist systems. Innovative materials would enable the redesign, in the post project activity, construction of ventricular heart assist.


Bio-inspired materials niche-like structures thin coatings haemocompatibility electron microscopy 


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  1. 1.
    Linheng, L., Xie, T.: Stem cell niche: structure and function. Annual review of cell and developmental biology. Annu Rev Cell Dev Biol. 21, 605–31 (2005)Google Scholar
  2. 2.
    Gomez-Gaviro M. V., Lovell-Badge, R., Fernandez-Aviles, F., Lara-Pezzi, E.: The Vascular Stem Cell Niche. J. of Cardiovasc. Trans. Res.5, 618–630 (2012)Google Scholar
  3. 3.
    Chen, S., Lewallen, M., Xie, T.: Adhesion in stem cell niche: biological roles and regulation. Development. 140(2), 255–65 (2013)Google Scholar
  4. 4.
    Fuchs, E., Tumbar, T., Guasch, G.: Socializing with the neighbors: stem cells and their niche. Cell 116(6), 769–778 (2004)Google Scholar
  5. 5.
    Moore, K. A., Lemischka, I. R.: Stem cells and their niches. Science, 311(5769), 1880–1885 (2006)Google Scholar
  6. 6.
    Farooque, T.M., Camp, Ch. H.Jr, Tison, Ch. K., Kumar, G., Parekh, S. H., Simon, C. G. Jr.: Measurin stem cell dimensionality in tissue scaffolds. Biomaterials 35, 2558–2567 (2014)Google Scholar
  7. 7.
    Turner, L.A., Dalby, M. J.: Nanotopography -potential relevance in the stem cell niche. Biomater. Sci. 2, 1574–1594 (2014)Google Scholar
  8. 8.
    Laha, A., Bhattacharyya, S., Krupanidhi, S.B.: Impact of microstructure on dielectric properties of Pb(Mg1/3Nb2/3)O3-PbTiO3 thin films. Materials Science and Engineering B. 106, 111–119 (2004)Google Scholar
  9. 9.
    Thornton, J. A.: High Rate Thick Film Growth - Annual Reviews Ann. Res. Mat. Sci. 7, 239 (1977)Google Scholar
  10. 10.
    Lackner, J. M.: Industrially-styled room-temperature pulsed laser deposition of titanium-based coatings. Vacuum 78, 73-82 (2005)Google Scholar
  11. 11.
    Peppas, N. A.: Hydrogels in Medicine and Pharmacy, CRC Press (1987)Google Scholar
  12. 12.
    Hickey A.S., Peppas N.A., Mesh size and diffusive characteristics of semicrystalline poly (vinyl alcohol) membranes prepared by freezing/thawing techniques Journal of Membrane Science 11, 229–237 (1995)Google Scholar
  13. 13.
    Seyfert, U.T., Biehl, V., Schenk, J.: In vitro hemocompatibility testing of biomaterials according to the ISO 109934 Biomol. Eng. 19, 91–96 (2002)Google Scholar
  14. 14.
    Anderson, J. M., Schoen, J.: in In vivo assessment of tissue compatibility, ed. B. D. Ratner, A. S. Hoffman, F. J. Schoen and J. E. Lemons, Biomaterials Science, An introduction to materials in medicine, Elsevier Academic Press, San Diego. 360–366 (2004)Google Scholar
  15. 15.
    Sanak, M., Jakiela B., Wegrzyn, W.: Assessment of hemocompatibility of materials with arterial blood flow by platelet functional tests Bulletin of the Polish Academy of Sciences: Technical Sciences, 58(2), 317–322 (2010)Google Scholar
  16. 16.
    Lackner, J.M., Wilczek, P., Sanak, M., Jakiela, B., Stolarzewicz, B.: Kowalczuk, M., Sobota, M., Maksymow, K., Spisak, M., Major, B., Functional cardio-biomaterials. Advances in Materials Science. 11(2), 5–25 (2011)Google Scholar
  17. 17.
    Major, R.: Self-assembling surfaces of blood-contacting materials. Journal of Material Science Materials in Medicine; Springer 24, 725–733 (2013)Google Scholar
  18. 18.
    Dardik, R., Savion, N., Gal, N., Varon, D.: Flow conditions modulate homocysteine induced changes in the expression of endothelial cell genes associated with cell-cell interaction and cytoskeletal rearrangement. Thrombosis and Haemostasis. 88, 1047–1053 (2002)Google Scholar
  19. 19.
    Germanier Y., Tosatti S., Broggini N., Textor M., Buser D.: Enhanced bone appo- sition around biofunctionalized sandblasted and acidetched titanium implant surfaces. A histomorphometric study in miniature pigs. Clin Oral Impl Res. 17, 251–257 (2006)Google Scholar
  20. 20.
    Shenkman, B., Inbal, A., Tamarin, I., Lubetsky, A., Savion, N., Varon, D.: Di- agnosis of thrombotic thrombocytopenic purpura based on modulation by patient plasma of normal platelet adhesion under flow condition. Br. J. Haematol.. 120, 597–604 (2003)Google Scholar
  21. 21.
    Wang, X., Dorsam, R.T., Lauver, A., Wang, H., Barbera, F.A., Gibbs, S., Varon, D., Savion, N., Friedman, S.M., Feuerstein, G.Z.: Comparative analysis of various platelet glycoprotein IIb/IIIa antagonists on shear-induced platelet activation and adhesion J. Pharmacol. Exp. Ther. 303(3), 1114–1120 (2002)Google Scholar

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© Springer International Publishing AG 2018

Authors and Affiliations

  • Roman Major
    • 1
    Email author
  • Klaudia Trembecka-Wojciga
    • 1
  • Jürgen Markus Lackner
    • 2
  • Bogusław Major
    • 1
  1. 1.Institute of Metallurgy and Materials Science; Polish Academy of SciencesCracowPoland
  2. 2.Joanneum Research Forschungsges mbH, Institute of Surface Technologies and Photonics, Functional SurfacesNiklasdorfAustria

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