Erythema Multiforme and Stevens-Johnson Syndrome
Erythema multiforme (EM) is an acute, self-limited, occasionally recurring skin disease considered to be a type IV hypersensitivity reaction to certain infections, medications, and other triggering factors. The skin disease may present within a wide spectrum of severity: EM minor is characterized by pathognomonic target- or iris-like cutaneous lesions with minimal or no mucosal involvement, whereas EM major shows extensive involvement of the mucosal membranes and frequently systemic symptoms. The timely affection of skin and mucous membranes in EM has created confusion with other severe dermatoses, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). In recent years, evidence has been provided that EM major and SJS/TEN are separate entities clinically manifested with similar cutaneous and mucosal involvement differing not only in severity but also in several demographic characteristics and causes [1, 2].
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