Introduction to Neuroendocrine Tumors

  • George C. Nikou


Neuroendocrine tumors (NETs) are tumors of the interface between the endocrine and nervous system. Two debated terminological issues have arisen with novel classifications: the use of the term endocrine versus neuroendocrine and that of neoplasms instead of tumors (neuroendocrine neoplasms – NEN). Although there may be arguments favoring each term, it must be recognized that they are essentially synonymous and are widely understood. For the sake of uniformity, the terms neuroendocrine tumors and carcinoid tumors will be used throughout this chapter [1].


  1. 1.
    Nikou GC, Angelopoulos TP (2012) Current concepts on gastric carcinoid tumors. Gastroenterol Res Pract 2012(3):287825. (8 pages)PubMedPubMedCentralGoogle Scholar
  2. 2.
    Warner R (2005) Enteroendocrine tumors other than carcinoid: a review of clinically significant advances. Gastroenterology 128:1668–1684CrossRefGoogle Scholar
  3. 3.
    Nikou GC, Marinou K, Thomakos P et al (2008) Chromogranin A levels in diagnosis, treatment and follow-up of 42 patients with non-functioning pancreatic endocrine tumours. Pancreatology 8:510–519CrossRefGoogle Scholar
  4. 4.
    Hemminki K, Li X (2001) Incidence trends and risk factors of carcinoid tumors: a nationwide epidemiologic study from Sweden. Cancer 92:2204–2210CrossRefGoogle Scholar
  5. 5.
    Rindi G, Arnold R, Bosman FT, Capella C, Klimstra DS, Kloppel G et al (2010) Nomenclature and classification of neuroendocrine neoplasms the digestive system. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumours in the digestive system, 4th edn. IARC, Lyon, pp 13–14Google Scholar
  6. 6.
    Toumpanakis CG, Caplin ME (2008) Molecular genetics of gastroenteropancreatic neuroendocrine tumors. Am J Gastroenterol 103(3):729–732CrossRefGoogle Scholar
  7. 7.
    Reubi JC (1995) Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. J Nucl Med 36:1825–1835PubMedGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • George C. Nikou
    • 1
  1. 1.Section of Neuroendocrine Tumors, 3rd Department of Internal MedicineNational and Kapodistrian University of AthensAthensGreece

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