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Virally Induced Cancers

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Skin Diseases in the Immunosuppressed

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Abstract

Immunosuppressed patients are at particular risk for skin cancers caused by, or associated with, viral infection. This chapter reviews three viral-associated skin cancers: human herpesvirus-8-associated Kaposi’s sarcoma, Merkel cell polyomavirus-associated Merkel cell carcinoma, and HPV-associated cutaneous squamous cell carcinoma.

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Abbreviations

AIDS:

Acquired immunodeficiency syndrome

AJCC:

American Joint Committee on Cancer

AK:

Actinic keratosis

BCC:

Basal cell carcinoma

CK20:

Cytokeratin 20

CLL:

Chronic lymphocytic leukemia

cSCC:

Cutaneous squamous cell carcinoma

EGFR:

Epidermal growth factor receptor

EV:

Epidermodysplasia verruciformis

HAART:

Highly active antiretroviral treatment

HHV-8:

Human herpesvirus-8

HIV:

Human immunodeficiency virus

HPV:

Human papilloma virus

IRIS:

Immune reconstitution inflammatory syndrome

KC:

Keratinocyte carcinoma

KS:

Kaposi’s sarcoma

KSHV:

Kaposi’s sarcoma-associated herpesvirus

LANA:

Latency-associated nuclear antigen

LTAg:

Large T antigen

MCC:

Merkel cell carcinoma

MCD:

Multicentric Castleman’s Disease

MCPyV:

Merkel cell polyomavirus

NSE:

Neuron-specific enolase

PEL:

Primary effusion lymphoma

Rb:

Retinoblastoma

SEER:

Surveillance, epidemiology, and end results program

SLNB:

Sentinel lymph node biopsy

SOTR:

Solid organ transplant recipients

TTF-1:

Thyroid transcription factor-1

UVR:

Ultraviolet radiation

VEGF:

Vascular endothelial growth factor

vGPCR:

Viral G protein-coupled receptor

vIL-6:

Viral IL-6

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Authors and Affiliations

  1. Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA

    Ravinder S. Gogia M.D. & Sarah T. Arron M.D., Ph.D.

  2. School of Medicine, University of California, San Francisco, San Francisco, CA, USA

    Shawnbir Gogia M.D.

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  3. Sarah T. Arron M.D., Ph.D.
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Correspondence to Sarah T. Arron M.D., Ph.D. .

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  1. Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA

    Oscar R. Colegio

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Gogia, R.S., Gogia, S., Arron, S.T. (2018). Virally Induced Cancers. In: Colegio, O. (eds) Skin Diseases in the Immunosuppressed. Springer, Cham. https://doi.org/10.1007/978-3-319-68790-2_9

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  • DOI: https://doi.org/10.1007/978-3-319-68790-2_9

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