Abstract
Synaptic plasticity in hippocampal CA1 pyramidal neurons is accompanied and shaped by dendritic plasticity, the long-lasting and region-specific alteration of the biophysical properties of voltage-gated dendritic ion channels. Down-regulation of A-type potassium current \(I_{\mathrm {A}}\), observed after long-term potentiation induction, boosts the amplitude of somatic back-propagating action potentials and the associated calcium concentration in dendritic spines, increases the amplitude of the excitatory postsynaptic potentials and promotes synaptic integration. Using a detailed computational model of a CA1 pyramidal cell and a spike-timing-dependent synaptic plasticity (STDP) protocol we found that suppression of A-type potassium current \(I_{\mathrm {A}}\) leads to the increased dendritic excitability converting long-term depression to long-term potentiation in proximal synapses and supporting fast Hebbian plasticity in distal synapses on a hippocampal CA1 pyramidal neuron.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Badoual, M., Zou, Q., Davison, A.P., Rudolph, M., Bal, T., Fregnac, Y., Destexhe, A.: Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity. Int. J. Neural Syst. 16(2), 79–97 (2006)
Bi, G., Poo, M.: Synaptic modification by correlated activity: Hebb’s postulate revisited. Annu. Rev. Neurosci. 24, 139–166 (2001)
Chen, X., Yuan, L., Zhao, C., Birnbaum, S., Frick, A., Jung, W., Schwarz, T., Sweatt, J., Johnston, D.: Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons. J. Neurosci. 26(47), 12143–12151 (2006)
Frick, A., Magee, J., Johnston, D.: LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites. Nat. Neurosci. 7(2), 126–135 (2004)
Graupner, M., Brunel, N.: Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location. Proc. Natl. Acad. Sci. U.S.A. 109(10), 3991–3996 (2012)
Hines, M., Carnevale, N.: The NEURON simulation environment. Neural Comput. 9(6), 1179–1209 (1997)
Poirazi, P., Brannon, T., Mel, B.: Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37, 977–987 (2003)
Sjostrom, P.J., Hausser, M.: A cooperative switch determines the sign of synaptic plasticity in distal dendrites of neocortical pyramidal neurons. Neuron 51(2), 227–238 (2006)
Wang, Z., Xu, N.L., Wu, C.P., Duan, S., Poo, M.M.: Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications. Neuron 37(3), 463–472 (2003)
Wittenberg, G.M., Wang, S.S.: Malleability of spike-timing-dependent plasticity at the CA3-CA1 synapse. J. Neurosci. 26(24), 6610–6617 (2006)
Xu, J., Kang, N., Jiang, L., Nedergaard, M., Kang, J.: Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons. J. Neurosci. 25(7), 1750–1760 (2005)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this paper
Cite this paper
Saudargiene, A., Jackevicius, R., Graham, B.P. (2017). Interplay of STDP and Dendritic Plasticity in a Hippocampal CA1 Pyramidal Neuron Model. In: Lintas, A., Rovetta, S., Verschure, P., Villa, A. (eds) Artificial Neural Networks and Machine Learning – ICANN 2017. ICANN 2017. Lecture Notes in Computer Science(), vol 10613. Springer, Cham. https://doi.org/10.1007/978-3-319-68600-4_44
Download citation
DOI: https://doi.org/10.1007/978-3-319-68600-4_44
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-68599-1
Online ISBN: 978-3-319-68600-4
eBook Packages: Computer ScienceComputer Science (R0)