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Human Rabies in South Asia

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Neglected Tropical Diseases - South Asia

Part of the book series: Neglected Tropical Diseases ((NTD))

Abstract

Rabies is an acute progressive encephalomyelitis caused by any of the viruses from the genus Lyssavirus, family Rhabdoviridae. One of the most feared diseases known to have plagued mankind since antiquity, rabies is the most lethal infection known to science. Despite the availability of prophylactic biologics since 1885, about 61,000 humans worldwide continue to die of this zoonotic disease every year, mostly in Asia and Africa [1]. It continues to be a neglected disease in most of the rabies-endemic countries of South Asia, which is the geographic epicenter of this serious public health problem.

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Reference

  1. World Health Organization. WHO Expert Consultation on Rabies. Second report. World Health Organ Tech Rep Ser 2013;(982):1–139, back.

    Google Scholar 

  2. Badrane H, Bahloul C, Perrin P, Tordo N. Evidence of two Lyssavirus phylogroups with distinct pathogenicity and immunogenicity. J Virol. 2001;75(7):3268–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Nadin-Davis SA. Molecular epidemiology. In: Jackson AC, editor. Rabies-scientific basis of disease and its management. 3rd ed. Oxford: Academic; 2013. p. 123–77.

    Google Scholar 

  4. Smith PC, Lawhaswasdi K, Vick WE, Stanton JS. Isolation of rabies virus from fruit bats in Thailand. Nature. 1967;216(5113):384.

    Article  CAS  PubMed  Google Scholar 

  5. Pal SR, Arora B, Chhuttani PN, Broor S, Choudhury S, Joshi RM, et al. Rabies virus infection of a flying fox bat, Pteropus poliocephalus in Chandigarh, Northern India. Trop Geogr Med. 1980;32(3):265–7.

    CAS  PubMed  Google Scholar 

  6. Gunawardena PS, Marston DA, Ellis RJ, Wise EL, Karawita AC, Breed AC, et al. Lyssavirus in Indian Flying Foxes, Sri Lanka. Emerg Infect Dis. 2016;22(8):1456–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kuzmin IV, Niezgoda M, Carroll DS, Keeler N, Hossain MJ, Breiman RF, et al. Lyssavirus surveillance in bats, Bangladesh. Emerg Infect Dis. 2006;12(3):486–8.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Mani RS, Dovih DP, Ashwini MA, Chattopadhyay B, Harsha PK, Garg KM, Sudarshan S, Puttaswamaiah R, Ramakrishnan U, Madhusudana SN. Serological evidence of lyssavirus infection among bats in Nagaland, a North-Eastern state in India. Epidemiol Infect. 2017;145(8):1635–41.

    Article  CAS  PubMed  Google Scholar 

  9. Veeraraghavan N. A case of hydrophobia following bat bite. Madras Diocesan Press; 1954.

    Google Scholar 

  10. Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, et al. Estimating the global burden of endemic canine rabies. PLoS Negl Trop Dis. 2015;9(4):e0003709.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Fahrion AS, Mikhailov A, Abela-Ridder B, Giacinti J, Harries J. Human rabies transmitted by dogs: current status of global data, 2015. Wkly Epidemiol Rec. 2016;91(2):13–20.

    Google Scholar 

  12. Carrara P, Parola P, Brouqui P, Gautret P. Imported human rabies cases worldwide, 1990-2012. PLoS Negl Trop Dis. 2013;7(5):e2209.

    Article  PubMed  PubMed Central  Google Scholar 

  13. WHO-SEARO. Prevention and control of rabies in SAARC countries. Report of the workshop, Colombo, Sri Lanka 11–13 August 2015 http://www.searo.who.int/entity/emerging_diseases/documents/sea_cd_316.pdf. 2015.

  14. Boland TA, McGuone D, Jindal J, Rocha M, Cumming M, Rupprecht CE, et al. Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies. Ann Neurol. 2014;75(1):155–60.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Jackson AC, Randle E, Lawrance G, Rossiter JP. Neuronal apoptosis does not play an important role in human rabies encephalitis. J Neurovirol. 2008;14(5):368–75.

    Article  CAS  PubMed  Google Scholar 

  16. Kasempimolporn S, Hemachudha T, Khawplod P, Manatsathit S. Human immune response to rabies nucleocapsid and glycoprotein antigens. Clin Exp Immunol. 1991;84(2):195–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Lytle AG, Norton JE Jr, Dorfmeier CL, Shen S, McGettigan JP. B cell infection and activation by rabies virus-based vaccines. J Virol. 2013;87(16):9097–110.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Wanjalla CN, Faul EJ, Gomme EA, Schnell MJ. Dendritic cells infected by recombinant rabies virus vaccine vector expressing HIV-1 Gag are immunogenic even in the presence of vector-specific immunity. Vaccine. 2010;29(1):130–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Nakamichi K, Saiki M, Sawada M, Takayama-Ito M, Yamamuro Y, Morimoto K, et al. Rabies virus-induced activation of mitogen-activated protein kinase and NF-kappaB signaling pathways regulates expression of CXC and CC chemokine ligands in microglia. J Virol. 2005;79(18):11801–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Wallace RM, Gilbert A, Slate D, Chipman R, Singh A, Cassie W, et al. Right place, wrong species: a 20-year review of rabies virus cross species transmission among terrestrial mammals in the United States. PLoS One. 2014;9(10):e107539.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. Faber M, Pulmanausahakul R, Hodawadekar SS, Spitsin S, McGettigan JP, Schnell MJ, et al. Overexpression of the rabies virus glycoprotein results in enhancement of apoptosis and antiviral immune response. J Virol. 2002;76(7):3374–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Kramer RA, Marissen WE, Goudsmit J, Visser TJ, Clijsters-Van d, Horst M, Bakker AQ, et al. The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries. Eur J Immunol. 2005;35(7):2131–45.

    Article  CAS  PubMed  Google Scholar 

  23. Wright E, Temperton NJ, Marston DA, McElhinney LM, Fooks AR, Weiss RA. Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison. J Gen Virol. 2008;89(Pt 9):2204–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Lafon M. Rabies virus receptors. J Neurovirol. 2005;11(1):82–7.

    Article  CAS  PubMed  Google Scholar 

  25. Gluska S, Zahavi EE, Chein M, Gradus T, Bauer A, Finke S, et al. Rabies virus hijacks and accelerates the p75NTR retrograde axonal transport machinery. PLoS Pathog. 2014;10(8):e1004348.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  26. Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J. Human rabies: neuropathogenesis, diagnosis, and management. Lancet Neurol. 2013;12(5):498–513.

    Article  PubMed  Google Scholar 

  27. Wei Y, Gong K, Ao Q, Wang A, Gong Y, Zuo H, et al. Lentiviral vectors enveloped with rabies virus glycoprotein can be used as a novel retrograde tracer to assess nerve recovery in rat sciatic nerve injury models. Cell Tissue Res. 2014;355(2):255–66.

    Article  CAS  PubMed  Google Scholar 

  28. Kato S, Kobayashi K, Kobayashi K. Improved transduction efficiency of a lentiviral vector for neuron-specific retrograde gene transfer by optimizing the junction of fusion envelope glycoprotein. J Neurosci Methods. 2014;227:151–8.

    Article  CAS  PubMed  Google Scholar 

  29. Piccinotti S, Whelan SP. Rabies internalizes into primary peripheral neurons via clathrin coated pits and requires fusion at the cell body. PLoS Pathog. 2016;12(7):e1005753.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  30. Klingen Y, Conzelmann KK, Finke S. Double-labeled rabies virus: live tracking of enveloped virus transport. J Virol. 2008;82(1):237–45.

    Article  CAS  PubMed  Google Scholar 

  31. Tan GS, Preuss MA, Williams JC, Schnell MJ. The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proc Natl Acad Sci USA. 2007;104(17):7229–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Shuangshoti S, Thorner PS, Teerapakpinyo C, Thepa N, Phukpattaranont P, Intarut N, et al. Intracellular spread of rabies virus is reduced in the paralytic form of canine rabies compared to the furious form. PLoS Negl Trop Dis. 2016;10(6):e0004748.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Lahaye X, Vidy A, Pomier C, Obiang L, Harper F, Gaudin Y, et al. Functional characterization of Negri bodies (NBs) in rabies virus-infected cells: evidence that NBs are sites of viral transcription and replication. J Virol. 2009;83(16):7948–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Hemachudha T, Wacharapluesadee S, Lumlertdaecha B, Orciari LA, Rupprecht CE, Laongpant M, et al. Sequence analysis of rabies virus in humans exhibiting encephalitic or paralytic rabies. J Infect Dis 2003;188(7):960-966.

    Google Scholar 

  35. Morimoto K, Hooper DC, Spitsin S, Koprowski H, Dietzschold B. Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J Virol. 1999;73(1):510–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Okada K, Ito N, Yamaoka S, Masatani T, Ebihara H, Goto H, et al. Roles of the rabies virus phosphoprotein isoforms in pathogenesis. J Virol. 2016;90(18):8226–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Masatani T, Ozawa M, Yamada K, Ito N, Horie M, Matsuu A, et al. Contribution of the interaction between the rabies virus P protein and I-kappa B kinase to the inhibition of type I IFN induction signalling. J Gen Virol. 2016;97(2):316–26.

    Article  CAS  PubMed  Google Scholar 

  38. Gregorio J, Meller S, Conrad C, Di NA, Homey B, Lauerma A, et al. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med. 2010;207(13):2921–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Mahoney E, Reichner J, Bostom LR, Mastrofrancesco B, Henry W, Albina J. Bacterial colonization and the expression of inducible nitric oxide synthase in murine wounds. Am J Pathol. 2002;161(6):2143–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Galelli A, Baloul L, Lafon M. Abortive rabies virus central nervous infection is controlled by T lymphocyte local recruitment and induction of apoptosis. J Neurovirol. 2000;6(5):359–72.

    Article  CAS  PubMed  Google Scholar 

  41. Shuangshoti S, Thepa N, Phukpattaranont P, Jittmittraphap A, Intarut N, Tepsumethanon V, et al. Reduced viral burden in paralytic compared to furious canine rabies is associated with prominent inflammation at the brainstem level. BMC Vet Res. 2013;9:31.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Gilbert AT, Petersen BW, Recuenco S, Niezgoda M, Gomez J, Laguna-Torres VA, et al. Evidence of rabies virus exposure among humans in the Peruvian Amazon. Am J Trop Med Hyg. 2012;87(2):206–15.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Holzmann-Pazgal G, Wanger A, Degaffe G, Rose C, Heresi G, Amaya R, et al. Presumptive abortive human rabies—Texas, 2009. MMWR Morb Mortal Wkly Rep. 2010;59(7):185–90.

    Google Scholar 

  44. O'Sullivan A, Willoughby RE, Mishchuk D, Alcarraz B, Cabezas-Sanchez C, Condori RE, et al. Metabolomics of cerebrospinal fluid from humans treated for rabies. J Proteome Res. 2013;12(1):481–90.

    Article  PubMed  CAS  Google Scholar 

  45. Willoughby RE Jr, Opladen T, Maier T, Rhead W, Schmiedel S, Hoyer J, et al. Tetrahydrobiopterin deficiency in human rabies. J Inherit Metab Dis. 2008;32(1):65–72.

    Article  PubMed  CAS  Google Scholar 

  46. Jogai S, Radotra BD, Banerjee AK. Rabies viral antigen in extracranial organs: a post-mortem study. Neuropathol Appl Neurobiol. 2002;28(4):334–8.

    Article  CAS  PubMed  Google Scholar 

  47. de Morais CF, de Assis RV. Cardiac involvement in human rabies. Case report. Rev Inst Med Trop Sao Paulo. 1985;27(3):145–9.

    Article  PubMed  Google Scholar 

  48. Pathak S, Horton DL, Lucas S, Brown D, Quaderi S, Polhill S, et al. Diagnosis, management and post-mortem findings of a human case of rabies imported into the United Kingdom from India: a case report. Virol J. 2014;11:63.

    PubMed  PubMed Central  Google Scholar 

  49. Hemachudha T, Sunsaneewitayakul B, Desudchit T, Suankratay C, Sittipunt C, Wacharapluesadee S, et al. Failure of therapeutic coma and ketamine for therapy of human rabies. J Neurovirol. 2006;12(5):407–9.

    Article  PubMed  Google Scholar 

  50. Mori T, Katayama Y, Kawamata T, Hirayama T. Improved efficiency of hypervolemic therapy with inhibition of natriuresis by fludrocortisone in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg. 1999;91(6):947–52.

    Article  CAS  PubMed  Google Scholar 

  51. Nathan BR. Cerebral correlates of hyponatremia. Neurocrit Care. 2007;6(1):72–8.

    Article  CAS  PubMed  Google Scholar 

  52. Willoughby RE, Roy-Burman A, Martin KW, Christensen JC, Westenkirchner DF, Fleck JD, et al. Generalized cranial artery spasm in human rabies. Dev Biol. 2008;131:367–75.

    CAS  Google Scholar 

  53. Solomon T, Marston D, Mallewa M, Felton T, Shaw S, McElhinney LM, et al. Paralytic rabies after a two week holiday in India. BMJ. 2005;331(7515):501–3.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Netravathi M, Udani V, Mani R, Gadad V, Ashwini M, Bhat M, et al. Unique clinical and imaging findings in a first ever documented PCR positive rabies survival patient: A case report. J Clin Virol. 2015;70:83–8.

    Article  Google Scholar 

  55. Wiedeman J, Plant J, Glaser C, Messenger S, Wadford D, Sheriff H, et al. Recovery of a patient from clinical rabies—California, 2011. MMWR Morb Mortal Wkly Rep. 2012;61(4):61–5.

    Google Scholar 

  56. Dietzschold B, Kao M, Zheng YM, Chen ZY, Maul G, ZF F, et al. Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system. Proc Natl Acad Sci USA. 1992;89(15):7252–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Anderson LJ, Nicholson KG, Tauxe RV, Winkler WG. Human rabies in the United States, 1960 to 1979: epidemiology, diagnosis, and prevention. Ann Intern Med. 1984;100(5):728–35.

    Article  CAS  PubMed  Google Scholar 

  58. Caicedo Y, Paez A, Kuzmin I, Niezgoda M, Orciari LA, Yager PA, et al. Virology, immunology and pathology of human rabies during treatment. Pediatr Infect Dis J. 2015;34(5):520–8.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Hemachudha T, Laothamatas J, Rupprecht CE. Human rabies: a disease of complex neuropathogenetic mechanisms and diagnostic challenges. Lancet Neurol. 2002;1(2):101–9.

    Article  PubMed  Google Scholar 

  60. Gable MS, Gavali S, Radner A, Tilley DH, Lee B, Dyner L, et al. Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis. 2009;28(12):1421–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Mallewa M, Fooks AR, Banda D, Chikungwa P, Mankhambo L, Molyneux E, et al. Rabies encephalitis in malaria-endemic area, Malawi, Africa. Emerg Infect Dis. 2007;13(1):136–9.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Lentz TL, Wilson PT, Hawrot E, Speicher DW. Amino acid sequence similarity between rabies virus glycoprotein and snake venom curaremimetic neurotoxins. Science. 1984;226(4676):847–8.

    Article  CAS  PubMed  Google Scholar 

  63. Sheikh KA, Ramos-Alvarez M, Jackson AC, Li CY, Asbury AK, Griffin JW. Overlap of pathology in paralytic rabies and axonal Guillain-Barre syndrome. Ann Neurol. 2005;57(5):768–72.

    Article  PubMed  Google Scholar 

  64. Hantson P, Guerit JM, de Tourtchaninoff M, Deconinck B, Mahieu P, Dooms G, et al. Rabies encephalitis mimicking the electrophysiological pattern of brain death. A case report. Eur Neurol. 1993;33(3):212–7.

    Article  CAS  PubMed  Google Scholar 

  65. Kumar KV, Ahmad FM, Dutta V. Pituitary cachexia after rabies encephalitis. Neurol India. 2015;63(2):255–6.

    Article  PubMed  Google Scholar 

  66. Rubin J, David D, Willoughby RE Jr, Rupprecht CE, Garcia C, Guarda DC, et al. Applying the Milwaukee protocol to treat canine rabies in Equatorial Guinea. Scand J Infect Dis. 2009;41(5):372–5.

    Article  PubMed  Google Scholar 

  67. Wright E, McNabb S, Goddard T, Horton DL, Lembo T, Nel LH, et al. A robust lentiviral pseudotype neutralisation assay for in-field serosurveillance of rabies and lyssaviruses in Africa. Vaccine. 2009;27(51):7178–86.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Mehta S, Sreenivasamurthy S, Banerjee S, Mukherjee S, Prasad K, Chowdhary A. Pathway analysis of proteomics profiles in rabies infection: towards future biomarkers? OMICS. 2016;20(2):97–109.

    Article  CAS  PubMed  Google Scholar 

  69. French CD, Willoughby RE, Mwaikambo ED, Granger DL, Foley JF, Wong SJ, et al. Cerebrospinal fluid metabolomics rapidly discriminates rabies from other inflammatory brain diseases. Rabies in the Americas XXVI, Ft. Collins, 4–8 Oct 2015. 2015.

    Google Scholar 

  70. Cox JA, Lukande RL, Kalungi S, Van de Vijver K, Van Marck E, Nelson AM, et al. Practice of percutaneous needle autopsy; a descriptive study reporting experiences from Uganda. BMC Clin Pathol. 2014;14(1):44.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Madhusudana SN, Subha S, Thankappan U, Ashwin YB. Evaluation of a direct rapid immunohistochemical test (dRIT) for rapid diagnosis of rabies in animals and humans. Virol Sin. 2012;27(5):299–302.

    Article  CAS  PubMed  Google Scholar 

  72. Dean DJ, Abelseth MK, Atanasiu P. The fluorescent antibody test. In: Meslin FX, Koprowsky H, Kaplan MM, editors. WHO laboratory techniques in rabies. 4th ed. Geneva: WHO; 1996. p. 88–95.

    Google Scholar 

  73. Mani RS, Madhusudana SN. Laboratory diagnosis of human rabies: recent advances. Scientific World J. 2013;2013:569712.

    Article  Google Scholar 

  74. Lembo T, Niezgoda M, Velasco-Villa A, Cleaveland S, Ernest E, Rupprecht CE. Evaluation of a direct, rapid immunohistochemical test for rabies diagnosis. Emerg Infect Dis. 2006;12(2):310–3.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Madhusudana SN. Rabies. Gurgaon: Macmillan Medical Communications; 2011.

    Google Scholar 

  76. Mani RS, Madhusudana SN, Mahadevan A, Reddy V, Belludi AY, Shankar SK. Utility of real-time Taqman PCR for antemortem and postmortem diagnosis of human rabies. J Med Virol. 2014;86:1804–12.

    Article  CAS  PubMed  Google Scholar 

  77. Mani RS, Anand AM, Madhusudana SN. Human rabies in India: an audit from a rabies diagnostic laboratory. Tropical Med Int Health. 2016;21(4):556–63.

    Article  CAS  Google Scholar 

  78. Wacharapluesadee S, Sutipanya J, Damrongwatanapokin S, Phumesin P, Chamnanpood P, Leowijuk C, Hemachudha T. Development of a TaqMan real-time RT-PCR assay for the detection of rabies virus. J Virol Methods. 2008;151(2):317–20.

    Article  CAS  PubMed  Google Scholar 

  79. Koprowsky H. The mouse inoculation test. In: Meslin FX, Kaplan MM, Koprowsky H, editors. Laboratory techniques in rabies. 4th ed. Geneva, Switzerland: WHO; 1996. p. 80–7.

    Google Scholar 

  80. Webster WA, Casey GA. Virus isolation in neuroblastoma cell culture. In: Meslin FX, Kaplan MM, Koprowsky H, editors. Laboratory techniques in rabies. 4th ed. Geneva, Switzerland: WHO; 1996. p. 96–104.

    Google Scholar 

  81. Crepin P, Audry L, Rotivel Y, Gacoin A, Caroff C, Bourhy H. Intravitam diagnosis of human rabies by PCR using saliva and cerebrospinal fluid. J Clin Microbiol. 1998;36(4):1117–21.

    CAS  PubMed  PubMed Central  Google Scholar 

  82. Noah DL, Drenzek CL, Smith JS, et al. Epidemiology of human rabies in the United States, 1980 to 1996. Ann Intern Med. 1998;128:922–30.

    Article  CAS  PubMed  Google Scholar 

  83. Blenden DC, Creech W, Torres-Anjel MJ. Use of immunofluorescence examination to detect rabies virus antigen in the skin of humans with clinical encephalitis. J Infect Dis. 1986;154:698–701.

    Article  CAS  PubMed  Google Scholar 

  84. Dacheux L, Reynes JM, Buchy P, et al. A reliable diagnosis of human rabies based on analysis of skin biopsy samples. Clin Infect Dis. 2008;47:1410–7.

    Article  PubMed  Google Scholar 

  85. Nagaraj T, Vasanth JP, Desai A, Kamat A, Madhusudana SN, Ravi V. Ante mortem diagnosis of human rabies using saliva samples: comparison of real time and conventional RT-PCR techniques. J Clin Virol. 2006;36(1):17–23.

    Article  CAS  PubMed  Google Scholar 

  86. Smith JS, Yager PA, Baer GM. A rapid fluorescent focus inhibition test (RFFIT) for determining rabies virus neutralizing antibody. In: Meslin FX, Kaplan MM, Koprowsky H, editors. Laboratory techniques in rabies. 4th ed. Geneva, Switzerland: WHO; 1996. p. 181–91.

    Google Scholar 

  87. Cliquet F, Aubert M, Sagné L. Development of a fluorescent antibody virus neutralisation test (FAVN test) for the quantitation of rabies-neutralising antibody. J Immunol Methods. 1998;212(1):79–87.

    Article  CAS  PubMed  Google Scholar 

  88. Willoughby RE Jr. Rabies: rare human infection—common questions. Infect Dis Clin North Am. 2015;29(4):637–50.

    Article  PubMed  Google Scholar 

  89. Mathuranayagam D, Rao PV. Antemortem diagnosis of human rabies by corneal impression smears using immuno fluorescent technique. Indian J Med Res. 1984;79:463–7.

    CAS  PubMed  Google Scholar 

  90. Human Rabies. Kentucky/Indiana, 2009. MMWR Morb Mortal Wkly Rep. 2010;59(13):393–6.

    Google Scholar 

  91. Manning SE, Rupprecht CE, Fishbein D, Hanlon CA, Lumlertdacha B, Guerra M, et al. Human rabies prevention—United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2008;57(RR-3):1–28.

    PubMed  Google Scholar 

  92. Marsden SC, Cabanban CR. Rabies: a significant palliative care issue. Progr Palliat Care. 2006;14(2):62–7.

    Article  Google Scholar 

  93. Tarantola A, Crabol Y, Mahendra BJ, In S, Barennes H, Bourhy H, et al. Caring for patients with rabies in developing countries—the neglected importance of palliative care. Tropical Med Int Health. 2016;21(4):564–7.

    Article  Google Scholar 

  94. Mani RS. Human rabies survivors in India: an emerging paradox? PLoS Negl Trop Dis. 2016;10(7):e0004774.

    Article  Google Scholar 

  95. Hasan D, Lindsay KW, Wijdicks EF, Murray GD, Brouwers PJ, Bakker WH, et al. Effect of fludrocortisone acetate in patients with subarachnoid hemorrhage. Stroke. 1989;20(9):1156–61.

    Article  CAS  PubMed  Google Scholar 

  96. Haught WH, Bertolet BD, Conti JB, Curtis AB, Mills RM Jr. Theophylline reverses high-grade atrioventricular block resulting from cardiac transplant rejection. Am Heart J. 1994;128(6 Pt 1):1255–7.

    Article  CAS  PubMed  Google Scholar 

  97. Yamada K, Noguchi K, Komeno T, Furuta Y, Nishizono A. Efficacy of Favipiravir (T-705) in rabies postexposure prophylaxis. J Infect Dis. 2016;213(8):1253–61.

    Article  CAS  PubMed  Google Scholar 

  98. De Clercq E. Curious (old and new) antiviral nucleoside analogues with intriguing therapeutic potential. Curr Med Chem. 2015;22(34):3866–80.

    Article  PubMed  CAS  Google Scholar 

  99. Caljon G, Caveliers V, Lahoutte T, Stijlemans B, Ghassabeh GH, Van Den Abbeele J, et al. Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier. Br J Pharmacol. 2012;165(7):2341–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Anderson GP, Teichler DD, Zabetakis D, Shriver-Lake LC, Liu JL, Lonsdale SG, et al. Importance of hypervariable region 2 for stability and affinity of a shark single-domain antibody specific for ebola virus nucleoprotein. PLoS One. 2016;11(8):e0160534.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  101. Vigilato MA, Cosivi O, Knobl T, Clavijo A, Silva HM. Rabies update for Latin America and the Caribbean. Emerg Infect Dis. 2013;19(4):678–9.

    Article  PubMed  PubMed Central  Google Scholar 

  102. Anonymous. India’s ongoing war against rabies. Bull World Health Organ. 2009;87(12):885–964.

    Article  Google Scholar 

  103. Tenzin T, Ahmed R, Debnath NC, Ahmed G, Yamage M. Free-roaming dog population estimation and status of the dog population management and rabies control program in Dhaka City, Bangladesh. PLoS Negl Trop Dis. 2015;9(5):e0003784.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Rinzin K, Tenzin T, Robertson I. Size and demography pattern of the domestic dog population in Bhutan: Implications for dog population management and disease control. Prev Vet Med. 2016;126:39–47.

    Article  PubMed  Google Scholar 

  105. Karunanayake D, Matsumoto T, Wimalaratne O, Nanayakkara S, Perera D, Nishizono A, et al. Twelve years of rabies surveillance in Sri Lanka, 1999-2010. PLoS Negl Trop Dis. 2014;8(10):e3205.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Reece JF, Chawla SK. Control of rabies in Jaipur, India, by the sterilisation and vaccination of neighbourhood dogs. Vet Rec. 2006;159(12):379–83.

    Article  CAS  PubMed  Google Scholar 

  107. Totton SC, Wandeler AI, Zinsstag J, Bauch CT, Ribble CS, Rosatte RC, et al. Stray dog population demographics in Jodhpur, India following a population control/rabies vaccination program. Prev Vet Med. 2010;97(1):51–7.

    Article  PubMed  Google Scholar 

  108. Abbas SS, Venkataramanan V, Pathak G, Kakkar M. Rabies control initiative in Tamil Nadu, India: a test case for the ‘One Health’ approach. Int Health. 2011;3(4):231–9.

    Article  PubMed  Google Scholar 

  109. Gibson AD, Ohal P, Shervell K, Handel IG, Bronsvoort BM, Mellanby RJ, et al. Vaccinate-assess-move method of mass canine rabies vaccination utilising mobile technology data collection in Ranchi, India. BMC Infect Dis. 2015;15:589.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  110. Anonymous. Sikkim hoping to become first rabies-free state. 14 May 2012.

    Google Scholar 

  111. Ravish HS, Srikanth J, Ashwath Narayana DH, Annadani R, Vijayashankar V, Undi M. Pre-exposure prophylaxis against rabies in children: safety of purified chick embryo cell rabies vaccine (Vaxirab N) when administered by intradermal route. Hum Vaccin Immunother. 2013;9(9):1910–3.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Vashishtha VM, Choudhury P, Kalra A, Bose A, Thacker N, Yewale VN, et al. Indian Academy of Pediatrics (IAP) recommended immunization schedule for children aged 0 through 18 years—India, 2014 and updates on immunization. Indian Pediatr. 2014;51(10):785–800.

    Article  PubMed  Google Scholar 

  113. Suwansrinon K, Wilde H, Benjavongkulchai M, Banjongkasaena U, Lertjarutorn S, Boonchang S, et al. Survival of neutralizing antibody in previously rabies vaccinated subjects: a prospective study showing long lasting immunity. Vaccine. 2006;24(18):3878–80.

    Article  CAS  PubMed  Google Scholar 

  114. Huang F, Ahmad W, Duan M, Liu Z, Guan Z, Zhang M, et al. Efficiency of live attenuated and inactivated rabies viruses in prophylactic and post exposure vaccination against the street virus strain. Acta Virol. 2015;59(2):117–24.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Rodney E. Willoughby .

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Mani, R.S., Willoughby, R.E. (2017). Human Rabies in South Asia. In: Singh, S. (eds) Neglected Tropical Diseases - South Asia. Neglected Tropical Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-68493-2_11

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