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Pathobiology of Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Part of the Molecular Pathology Library book series (MPLB)

Abstract

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma representing around 5% of all Hodgkin lymphomas. It usually affects middle-aged men and has an indolent clinical behavior. In contrast to classical Hodgkin lymphoma, the tumor cells of NLPHL—called LP cells—express B-cell antigens. Different histopathological growth patterns related to the clinical behavior of NLPHL can be observed. In around 1/3 of NLPHL, the LP cells harbor translocations involving the BCL6 locus. Furthermore, somatic mutations of SOCS1, JUNB, DUSP2, and SGK1 are frequently found in LP cells. In this chapter we discuss the clinical behavior, morphologic growth patterns, immunophenotype, and molecular and genetic features of NLPHL.

Keywords

Nodular lymphocyte predominant Hodgkin lymphoma Immunophenotype Genetic lesions Cell of origin Microenvironment 

Abbreviations

CGH

Comparative genomic hybridization

cHL

Classical Hodgkin lymphoma

DLBCL

Diffuse large B-cell lymphoma

HLA

Human leukocyte antigen

NF-kappaB

Nuclear factor kappa B

NLPHL

Nodular lymphocyte predominant Hodgkin lymphoma

PTGC

Progressive transformation of germinal centers

THRLBCL

T cell/histiocyte rich large B-cell lymphoma

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Dr. Senckenberg Institute of Pathology, Goethe University HospitalFrankfurt am MainGermany

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