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Precision Molecular Pathology of Hodgkin Lymphoma pp 59–90Cite as

Targeting the Microenvironment in Hodgkin Lymphoma: Opportunities and Challenges

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Part of the book series: Molecular Pathology Library ((MPLB))

Abstract

The tumor cells in Hodgkin lymphoma (HL) constitute a minority of the affected tissue, while the microenvironment constitutes more than 95% of the total cell population. It has become evident that the infiltrating cells are not just innocent bystanders but active players involved in the pathogenesis of HL. The apparent dependence of the tumor cells on cells present in the microenvironment indicates the potential for therapeutic intervention aiming at targeting specific cell types or factors in the microenvironment. This can be achieved by inhibiting tumor cell-supporting signals or eliminating suppressive factors of the antitumor immune response. In this chapter we will summarize the individual components of the microenvironment, their relevance for tumor cell survival, and possible therapeutic interventions aiming at shifting the balance from a tumor cell-supporting toward a tumor cell-killing microenvironment.

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Abbreviations

B2M:

β2-microglobulin

CC:

CC chemokine

CIITA:

Class II transactivator

CREBBP:

cAMP response element-binding protein-binding protein

CTGF:

Connective tissue growth factor

CTLA4:

Cytotoxic T-lymphocyte-associated protein 4

CTLs:

Cytotoxic T cells

CXC:

CXC chemokine

DDR:

Discoidin domain receptor tyrosine kinase

DHMEQ:

Dehydroxymethylepoxyquinomicin

DLBCL:

Diffuse large B-cell lymphoma

EBNA:

Epstein-Barr nuclear antigen

EBV:

Epstein-Barr virus

EPHB1:

Ephrin type-B receptor 1

HDAC:

Histone deacetylases

HGF:

Hepatocyte growth factor

HL:

Classical Hodgkin lymphoma

HLA:

Human leukocyte antigen

HRS:

Hodgkin and Reed-Sternberg

HSP:

Heat shock protein

HuR:

Human antigen R

IL:

Interleukin

L:

Ligand

Lag3:

Lymphocyte-activation protein 3

LFA:

Lymphocyte function-associated antigen

LMP:

Latent membrane protein

LP:

Lymphocyte-predominant tumor

LT:

Lymphotoxin

MAGE-A4:

Melanoma-associated antigen 4

MAPK:

Mitogen-activated protein kinase

miR:

MicroRNA

NF-κB:

Nuclear factor-kappa B

NGF:

Nerve growth factor

NIK:

NF-κB-inducing kinase

NK:

Natural killer

NKG2D:

NK cell receptor D

NLPHL:

Nodular lymphocyte-predominant Hodgkin lymphoma

NS:

Nodular sclerosis

ORR:

Objective response rate

PD-1:

Programmed cell death protein 1

PDGFRA:

Platelet-derived growth factor receptor alpha

PMBCL:

Primary mediastinal large B-cell lymphoma

PRAME:

Preferentially expressed antigen in melanoma

PTPN1:

Protein tyrosine phosphatase, non-receptor type 1

R:

Receptor

RON:

Recepteur d’origine nantais

RTK:

Receptor tyrosine kinases

SOCS:

Suppressor of cytokine signaling

SSX2:

Synovial sarcoma X

Tfh:

T follicular helper

TGF:

Transforming growth factor

Th:

T helper

TIM3:

T-cell immunoglobulin and mucin-domain containing-3

TNF:

Tumor necrosis factor

TNFAIP3:

TNF alpha-induced protein 3

TNFRSF:

Tumor necrosis factor receptor superfamily

Tr-1:

T regulatory 1

TRAF:

TNF receptor-associated factor

Treg:

T regulatory cell

TRK:

Tropomyosin receptor kinase

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Authors and Affiliations

  1. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713, GZ Groningen, The Netherlands

    Lydia Visser, Arjan Diepstra & Anke van den Berg

  2. Center for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada

    Christian Steidl

  3. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

    Christian Steidl

Authors
  1. Lydia Visser
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  2. Arjan Diepstra
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  3. Christian Steidl
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  4. Anke van den Berg
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Correspondence to Lydia Visser .

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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

    S. David Hudnall

  2. Universität Duisburg-Essen, Institute for Cell Biology, Essen, Nordrhein-Westfalen, Germany

    Ralf Küppers

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Visser, L., Diepstra, A., Steidl, C., van den Berg, A. (2018). Targeting the Microenvironment in Hodgkin Lymphoma: Opportunities and Challenges. In: Hudnall, S., Küppers, R. (eds) Precision Molecular Pathology of Hodgkin Lymphoma . Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-68094-1_4

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  • DOI: https://doi.org/10.1007/978-3-319-68094-1_4

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