Novel Targeted Therapies in Hodgkin Lymphoma

Part of the Molecular Pathology Library book series (MPLB)


Although Hodgkin lymphoma (HL) is considered a highly curable cancer, a substantial portion of patients are relapsed/refractory to first-line therapies and even after subsequent autologous stem cell transplantation. These patients carry a poor prognosis with poor survival rates. In this area of high unmet medical need, development of novel targeted therapeutics is a significant priority. Fortunately, increased understanding of the molecular biology of HL has given rise to a number of new classes of drugs such as antibody drug conjugates, PD-1 and PD-L1 inhibitors, PI3K inhibitors, histone deacetylase inhibitors, Akt/mTOR pathway inhibitors, and immunomodulators. Numerous clinical trials evaluating these novel drugs have demonstrated a variety of responses and activities. This review will focus on recent developments and the growing armamentarium of drugs available to treat this disease.


Immunotherapy PD-1 CD30 Relapsed Refractory Antibody Brentuximab vedotin Nivolumab Pembrolizumab 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Hematology and Hematopoietic Cell TransplantationToni Stephenson Lymphoma Center, City of HopeDuarteUSA

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