Abstract
The treatment of generalised hypertonia in cerebral palsy (CP) with the use of oral medications can be challenging in terms of improvement in patient function and quality of life. Despite the duration of published experience in the use of oral medications in CP, evidence for effect is generally limited. Spasticity, which is characterised by a velocity-dependent increase in muscle tone, can be treated with medications including baclofen and diazepam with complementary effects at the GABA spinal receptor level. Gabapentin also has a GABA agonistic effect and has gained use in the treatment of both spasticity and dystonia. Experience in the treatment of dyskinetic CP, which includes dystonia, chorea and athetosis, has largely focused on dystonia management. Anticholinergic medications including trihexyphenidyl have shown promise with evidence for improvement in upper limb function. Levodopa is commonly used for dystonia despite a lack of evidence for effect. Effective treatment of chorea and athetosis in CP remains elusive.
References
Lin JP. The Assessment and management of hypertonus in cerebral palsy: a physiological atlas (‘Road Map’). In: Scrutton D, Damiano D, Mayston M, editors. Management of the motor disorders of children with cerebral palsy. Clinics in Developmental Medicine, vol. 161. London: MacKeith Press; 2004. p. 85–104.
World Health Organisation. Towards a common language for functioning, disability and health—ICF. Geneva: World Health Organisation; 2002.
Rice J, Waugh MC. Pilot study on Trihexyphenidyl in the treatment of dystonia in children with cerebral palsy. J Child Neurol. 2009;24:176–82.
Scheinberg A, Hall K, Lam L, O’Flaherty S. Oral baclofen in children with cerebral palsy: a double-blind cross-over pilot study. J Paediatr Child Health. 2006;42:715–20.
Sanger TD, Delgado MR, Gaebler-Spira D, et al. Classification and definition of disorders causing hypertonia in childhood. Pediatrics. 2003;111:e89–97.
Albright AL, Andrews M. Development of the hypertonia assessment tool. Dev Med Child Neurol. 2010;52:411–2.
Australian CP Register. Report of the Australian Cerebral Palsy Register, birth years 1993–2006; 2013.
Himmelmann K, Hagberg G, Uvebrant P. The changing panorama of cerebral palsy in Sweden. X. Prevalence and origin in the birth-year period 1999-2002. Acta Paediatr. 2010;99:1337–43.
Davidoff RA. Antispasticity drugs: mechanisms of Action. Ann Neurol. 1985;17:107–16.
Zeiglgansberger W, Howe JR, Sutor B. The neuropharmacology of baclofen. In: Mueller H, Zierski J, Rd P, editors. Local spinal therapy of spasticity. Berlin: Springer; 1988.
Milla PJ, Jackson ADM. A controlled trial of baclofen in children with cerebral palsy. J Int Med Res. 1977;5:398–404.
McKinlay I, Hyde E, Gordon N. Baclofen: a team approach to drug evaluation of spasticity in childhood. Scott Med J. 1980;25:S26–8.
Vargas-Adams JN, Michaud LJ, Kinnett DG, et al. Effects of baclofen on children with cerebral palsy. Dev Med Child Neurol. 2004;46:787.
Knuttson E, Lindblom U, Beissinger RL, Martensson A. Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimum therapeutic responses in spastic paresis. J Neurol Sci. 1974;23:473–84.
van Doornik J, Kukke S, McGill K, Rose J, Sherman-Levine S, Sanger TD. Oral baclofen increases maximal voluntary neuromuscular activation of ankle plantar flexors in children with spasticity due to cerebral palsy. J Child Neurol. 2008;23:635–9.
Mathew A, Mathew MC, Thomas M, Antonisamy B. The efficacy of diazepam in enhancing motor function in children with spastic cerebral palsy. J Trop Pediatr. 2005;51:109–13.
Engle HA. The effect of diazepam (Valium) in children with cerebral palsy: a double-blind study. Dev Med Child Neurol. 1966;8:661–7.
Holt KS (1964) The use of diazepam in childhood cerebral palsy. Report of a small study including electromyographic observations. Ann Phys Med. 1964;(Suppl):16–24.
Pinder RM, Brogden RN, Speight TM, et al. Dantrolene sodium: a review of its pharmacologic properties and therapeutic efficacy in spasticity. Drugs. 1977;13:3–23.
O’Donnell M, Armstrong R. Pharmacological interventions for management of spasticity in cerebral palsy. Ment Retard Dev Disabil Res Rev. 1997;3:204–11.
Denhoff E, Feldman S, Smith MG, et al. Treatment of spastic cerebral-palsied children with sodium dantrolene. Dev Med Child Neurol. 1975;17:736–42.
Joynt RL, Leonard JA Jr. Dantrolene sodium suspension in treatment of spastic cerebral palsy. Dev Med Child Neurol. 1980;22:755–67.
Vasquez-Briceno A, Arellano-Saldana ME, Leon-Hernandez SR, Morales-Osorio MG. The usefulness of tizanidine. A one-year follow-up of the treatment of spasticity in infantile cerebral palsy. Rev Neurol. 2006;43:132–6.
Palazon Garcia R, Benavente Valdepenas A, Arroyo Riano O. Protocol for tizanidine use in infantile cerebral palsy. Anal Pediatr. 2008;68:511–5.
Dai AI, Wasay M, Awan S. Botulinum toxin type A with oral baclofen versus oral tizanidine: a nonrandomized pilot comparison in patients with cerebral palsy and spastic equinus foot deformity. J Child Neurol. 2008;23:1464–6.
Lubsch L, Habersang R, Haase M, Luedtke S. Oral baclofen and clonidine for treatment of spasticity in children. J Child Neurol. 2006;21:1090–2.
Mueller ME, Gruenthal M, Olson WL, Olson WH. Gabapentin for relief of upper motor neuron symptoms in multiple sclerosis. Arch Phys Med Rehabil. 1997;78:521–4.
Liow NY, Gimeno H, Lumsden DE, et al. Gabapentin can significantly improve dystonia severity and quality of life in children. Eur J Paediatr Neurol. 2016;20:100–7.
Kostic V, Przedborski S, Jackson-Lewis V, et al. Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on striatal muscarinic cholinergic receptors and high-affinity choline uptake series: a quantitative autoradiographic study. J Neurochem. 1991;57:1962–70.
Burke RE, Karanasa AL. Quantitiative morphological analysis of striatal cholingeric neurones in perinatal asphyxia. Ann Neurol. 1990;27:81–8.
Barry MJ, Van Swearingen JM, Albright AL. Reliability and responsiveness of the Barry-Albright dystonia scale. Dev Med Child Neurol. 1999;41:404–11.
Sanger TD, Bastian A, Brunstrom J, et al. and the Child Motor Study Group. Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy. J Child Neurol. 2007;22:530–37.
Hoon AH Jr, Freese PO, Reinhardt EM, et al. Age-dependent effects of benzhexol in extrapyramidal cerebral palsy. Pediatr Neurol. 2001;25:55–8.
Fahn S. High dosage anticholinergic therapy in dystonia. Neurology. 1983;33:1255–61.
Jan MM. Misdiagnoses in children with dopa-responsive dystonia. Pediatr Neurol. 2004;31:298–303.
Pozin I, Bdolah-Abram T, Ben-Pazi H. Levodopa does not improve function in individuals with dystonic cerebral palsy. J Child Neurol. 2014;29:534–7.
O’Flaherty S, Waugh MC. Pharmacologic management of the spastic and dystonic upper limb in children with cerebral palsy. Hand Clin. 2003;19:585–9.
Vles GF, Hendriksen JG, Visschers A, et al. Levetiracetam therapy for treatment of choreoathetosis in dyskinetic cerebral palsy. Dev Med Child Neurol. 2009;51:487–90.
Woods SW, Saksa JR, Baker CB, et al. Effects of levetiracetam on tardive dyskinesia: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2008;69:546–54.
Jankovic J. Treatment of hyperkinetic movement disorders with tetrabenazine: a double-blind crossover study. Ann Neurol. 1982;11:41–7.
Heggarty H, Wright T. Tetrabenazine in athetoid cerebral palsy. Dev Med Child Neurol. 1974;16:137–42.
Chatterjee A, Frucht S. Tetrabenazine in the treatment of severe paediatric chorea. Mov Disord. 2003;18:703–6.
Harbord MG, Kobayashi JS. Fever producing ballismus in patients with choreoathetosis. J Child Neurol. 1991;6:49–52.
Delgado MR, Hirtz D, Aisen M, et al. Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review). Neurology. 2010;74:336–43.
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Rice, J. (2018). Oral Medication Use in Cerebral Palsy. In: Panteliadis, C. (eds) Cerebral Palsy. Springer, Cham. https://doi.org/10.1007/978-3-319-67858-0_24
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