CCES: Cancer Clonal Evolution Simulation Program
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We present Cancer Clonal Evolution Simulator (CCES)—a simulation system of the clonal growth of cancer cell populations with arbitrary selection patterns. It is possible record the life history of each separate cancer cell and to track propagation of mutations over cancer cells phylogenies at the scale of hundreds of thousands of cancer cells. Thanks to efficient implementation our system enables studying evolution of tumor tissues at the scale of hundreds of thousands of cancer cells.
KeywordsPopulation dynamics Cancer evolution Driver and passenger mutations Stochastic simulation
This work has been supported by the following grants: Silesian University of Technology, Institute of Informatics, Statute project, (BK/RAU-2/2016) to KS, National Science Centre, OPUS grant (2016/21/B/ST6/02153) to AP.
- 5.Hoban, S., Bertorelle, G., Gaggiotti, O.E.: Computer simulations: tools for population and evolutionary genetics. Nat. Rev. Genet. 13(2), 110–122 (2012)Google Scholar