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CCES: Cancer Clonal Evolution Simulation Program

  • Krzysztof Szymiczek
  • Aleksandra Gruca
  • Andrzej Polanski
Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 659)

Abstract

We present Cancer Clonal Evolution Simulator (CCES)—a simulation system of the clonal growth of cancer cell populations with arbitrary selection patterns. It is possible record the life history of each separate cancer cell and to track propagation of mutations over cancer cells phylogenies at the scale of hundreds of thousands of cancer cells. Thanks to efficient implementation our system enables studying evolution of tumor tissues at the scale of hundreds of thousands of cancer cells.

Keywords

Population dynamics Cancer evolution Driver and passenger mutations Stochastic simulation 

Notes

Acknowledgements

This work has been supported by the following grants: Silesian University of Technology, Institute of Informatics, Statute project, (BK/RAU-2/2016) to KS, National Science Centre, OPUS grant (2016/21/B/ST6/02153) to AP.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Krzysztof Szymiczek
    • 1
  • Aleksandra Gruca
    • 1
  • Andrzej Polanski
    • 1
  1. 1.Institute of InformaticsSilesian University of TechnologyGliwicePoland

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