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Radionanomedicine pp 105–123Cite as

Organic Nanomaterials: Liposomes, Albumin, Dendrimer, Polymeric Nanoparticles

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Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Organic nanoparticles (NPs) as a drug delivery system have a relative long history of development and many of them are now approved for commercial use. The nano-carrier used for drug delivery should be eliminated from the body, either by degradation or by excretion. While many inorganic nano-carriers are very stable and difficult to metabolize, many of organic NPs are biodegradable. Radiolabeling of biomolecules enables tracing these molecules in vivo. Biodistribution and autoradiography studies validate tissue distribution of the nano-carriers in animals. Nuclear medicine imaging such as single photon emission computed tomography (SPECT) or positron emission tomography (PET) allows non-invasive longitudinal monitoring of the in vivo pharmacokinetics and tissue distribution of the nano-carriers even in human subjects. In vivo tracking of nano-carriers using radionuclide imaging techniques enables a theranostic approach as well, not just being a drug carrier. The combination of diagnostic and therapeutic capabilities in a single drug delivery system can be used for precision personalized therapies. In this chapter, we dealt with four different groups of biodegradable organic NPs and their radiolabeled forms: liposomes, albumin-based nanoparticles, dendrimers, and polymeric nanoparticles.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea

    Keon Wook Kang & Myung Geun Song

  2. Cancer Research Institute, Seoul National University, Seoul, Republic of Korea

    Keon Wook Kang & Myung Geun Song

  3. Biomedical Research Institute, Seoul National University Hospital, Seoul, 03082, Republic of Korea

    Myung Geun Song

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  1. Keon Wook Kang
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Correspondence to Keon Wook Kang .

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Kang, K.W., Song, M.G. (2018). Organic Nanomaterials: Liposomes, Albumin, Dendrimer, Polymeric Nanoparticles. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_5

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