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Radionanomedicine pp 347–368Cite as

Excretion and Clearance

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Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

The nanomaterials administered to the body systems are cleared, degraded and finally excreted from the body. After the initial interaction of administered nanomaterials with the body systems, clearance/excretion process of the nanomaterials is started. Mononuclear phagocytic system clears nanomaterials from the circulation by sequestering them and hepatobiliary and renal excretion works thereafter. Considering the possible toxicity of nanomaterials, controlling the clearance and excretion of injected nanomaterials are mandatory. All the factors affecting clearance and excretion have veen investigated systematically and partially established. In this chapter, we describe the physiology of clearance and excretion, and factors affecting them. Designing better nanomaterials should be based on the thorough knowledge about this physiology of nanomaterials and radionanomaterials.

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Authors and Affiliations

  1. Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea

    Hyung-Jun Im

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Im, HJ. (2018). Excretion and Clearance. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_19

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