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Polyethylene Glycolation (PEGylation) and the Similar

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Radionanomedicine

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

To overcome the adverse effect of hydrophobicity of nanomaterials, polyethylene glycolation (PEGylation) is popularly used, which were already in clinical use of peptide or monoclonal antibodies. The same PEGylation is tried to hydrophilize nanomaterials but the results of this PEGylation differs according to the size, shape, terminal residues and others. The bodily response to the nanomaterials depend upon immune recognition of the PEG by IgM or innate immune cells. Mechanism of innate immune response to PEGylated nanomaterials are poorly understood. Zwitterions such as polybetaines were proposed to replace PEGs for hydrophilization. The mechanism is being investigated and not yet clearly known. The method to modify the surface of nanomaterials with PEGs and zwitterions can also influence final bodily response and thus simple and easy method of encapsulation was developed. The effect of diverse modification of nanomaterials with PEGs or zwitterions shall be understood with nanomaterials modified with this encapsulation method.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea

    Dong Soo Lee & Yun-Sang Lee

  2. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea

    Dong Soo Lee & Yun-Sang Lee

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  1. Dong Soo Lee
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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Lee, D.S., Lee, YS. (2018). Polyethylene Glycolation (PEGylation) and the Similar. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_18

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