Abstract
Quantification of the amount of radiolabeled nanomaterials distributed in the animal and human body is important for understanding their in vivo properties (e.g., target delivery, radiolabeling stability, and excretion pathway) and determining future applications. Tracer kinetic analyses could play a vital role in the success of radionanomedicine as it facilitates the development of clinically relevant nanomaterials by providing the pharmacokinetic information. In this chapter, we describe the methodology used in the tracer kinetic analysis of dynamic positron emission tomography (PET) and single photon emission computed tomography (SPECT), starting from how to record the time profiles of tracer concentration in the blood and tissues, two sources of data required for a tracer kinetic model. Compartment models commonly used in PET and SPECT tracer kinetic analysis and their operational equations for fitting the tissue time-activity curves will be introduced. Then, several robust parameter estimation methods will be described. Finally, we will introduce a few examples of the tracer kinetic analysis in radio-nanomaterial studies.
Keywords
- Tracer Kinetic Analysis
- Tissue Time-activity Curves
- Single Photon Emission Computed Tomography (SPECT)
- Robust Parameter Estimation Method
- Simplified Reference Tissue Model (SRTM)
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Lee, J.S., Seo, S., Lee, D.S. (2018). Tracer Kinetics in Radionanomedicine. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_16
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