Yersinia spp.

  • Douglas I. Johnson


  • Yersinia pestis (Ype) chromosome: 4,653,728 bp; 4012 predicted ORFs (Parkhill et al. 2001):
    • pPst/pPCP1: 9612 bp; 9 predicted ORFs

    • pYV1/pCD1: 70,305 bp; 97 predicted ORFs; found in all pathogenic Yersinia

    • pFra/pMT1: 96,210 bp; 103 predicted ORFs


  1. Atkinson S, Williams P (2016) Yersinia virulence factors – a sophisticated arsenal for combating host defences. F1000Research 5Google Scholar
  2. Barz C, Abahji TN, Trülzsch K, Heesemann J (2000) The Yersinia Ser/Thr protein kinase YpkA/YopO directly interacts with the small GTPases RhoA and Rac-1. FEBS Lett 482:139–143CrossRefPubMedGoogle Scholar
  3. Bearden SW, Perry RD (1999) The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague. Mol Microbiol 32:403–414CrossRefPubMedGoogle Scholar
  4. Bliska JB, Falkow S (1992) Bacterial resistance to complement killing mediated by the ail protein of Yersinia enterocolitica. Proc NatI Acad Sci USA 89:3561–3565CrossRefGoogle Scholar
  5. Boland A, Cornelis GR (1998) Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection. Infect Immun 66:1878–1884PubMedPubMedCentralGoogle Scholar
  6. Brubaker RR (2003) Interleukin-10 and inhibition of innate immunity to Yersiniae: roles of Yops and LcrV (V antigen). Infect Immun 71:3673–3681CrossRefPubMedPubMedCentralGoogle Scholar
  7. Chain PSG, Carniel E, Larimer FW, Lamerdin J, Stoutland PO, Regala WM, Georgescu AM, Vergez LM, Land ML, Motin VL, Brubaker RR, Fowler J, Hinnebusch J, Marceau M, Medigue C, Simonet M, Chenal-Francisque V, Souza B, Dacheux D, Elliott JM, Derbise A, Hauser LJ, Garcia E (2004) Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis. Proc NatI Acad Sci USA 101:13826–13831CrossRefGoogle Scholar
  8. Chung LK, Park YH, Zheng Y, Brodsky IE, Hearing P, Kastner DL, Chae JJ, Bliska JB (2016) The Yersinia virulence factor YopM hijacks host kinases to inhibit type III effector-triggered activation of the pyrin inflammasome. Cell Host Microbe 20:296–306CrossRefPubMedPubMedCentralGoogle Scholar
  9. Collyn F, Lety MA, Nair S, Escuyer V, Ben Younes A, Simonet M, Marceau M (2002) Yersinia pseudotuberculosis harbors a type IV pilus gene cluster that contributes to pathogenicity. Infect Immun 70:6196–6205CrossRefPubMedPubMedCentralGoogle Scholar
  10. Cornelis GR (2002) The Yersinia Ysc-Yop ‘type III’ weaponry. Nat Rev Mol Cell Biol 10:742–752CrossRefGoogle Scholar
  11. Cornelis GR, Wolf-Watz H (1997) The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells. Mol Microbiol 23:861–867CrossRefPubMedGoogle Scholar
  12. Delor I, Kaeckenbeeck A, Wauters G, Cornelis GR (1990) Nucleotide sequence of yst, the Yersinia enterocolitica gene encoding the heat-stable enterotoxin, and prevalence of the gene among pathogenic and nonpathogenic yersiniae. Infect Immun 58:2983–2988PubMedPubMedCentralGoogle Scholar
  13. Du Y (2002) Role of fraction 1 antigen of Yersinia pestis in inhibition of phagocytosis. Infect Immun 70:1453–1460CrossRefPubMedPubMedCentralGoogle Scholar
  14. Ellison DW, Lawrenz MB, Miller VL (2004) Invasin and beyond: regulation of Yersinia virulence by RovA. Trends Microbiol 12:296–300CrossRefPubMedGoogle Scholar
  15. Erhardt M, Dersch P (2015) Regulatory principles governing Salmonella and Yersinia virulence. Front Microbiol 6:949CrossRefPubMedPubMedCentralGoogle Scholar
  16. Fabrega A, Vila J (2012) Yersinia enterocolitica: pathogenesis, virulence and antimicrobial resistance. Enferm Infecc Microbiol Clin 30:24–32CrossRefPubMedGoogle Scholar
  17. Felek S, Krukonis ES (2009) The Yersinia pestis ail protein mediates binding and Yop delivery to host cells required for plague virulence. Infect Immun 77:825–836CrossRefPubMedGoogle Scholar
  18. Felek S, Lawrenz MB, Krukonis ES (2008) The Yersinia pestis autotransporter YapC mediates host cell binding, autoaggregation and biofilm formation. Microbiol 154:1802–1812CrossRefGoogle Scholar
  19. Galvan EM, Chen H, Schifferli DM (2007) The Psa fimbriae of Yersinia pestis interact with phosphatidylcholine on alveolar epithelial cells and pulmonary surfactant. Infect Immun 75:1272–1279CrossRefPubMedGoogle Scholar
  20. Gong S, Bearden SW, Geoffroy VA, Fetherston JD, Perry RD (2001) Characterization of the Yersinia pestis Yfu ABC inorganic iron transport system. Infect Immun 69:2829–2837CrossRefPubMedPubMedCentralGoogle Scholar
  21. Håkansson S, Schesser K, Persson C, Galyov EE, Rosqvist R, Homblé F, Wolf-Watz H (1996) The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. EMBO J 15:5812–5823PubMedPubMedCentralGoogle Scholar
  22. Iriarte M, Cornelis GR (1998) YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells. Mol Microbiol 29:915–929CrossRefPubMedGoogle Scholar
  23. Ke Y, Chen Z, Yang R (2013) Yersinia pestis: mechanisms of entry into and resistance to the host cell. Front Cell Infect Microbiol 3:106CrossRefPubMedPubMedCentralGoogle Scholar
  24. Keto-Timonen R, Hietala N, Palonen E, Hakakorpi A, Lindstrom M, Korkeala H (2016) Cold shock proteins: a minireview with special emphasis on Csp-family of enteropathogenic Yersinia. Front Microbiol 7:1151CrossRefPubMedPubMedCentralGoogle Scholar
  25. Kolodziejek AM, Hovde CJ, Minnich SA (2012) Yersinia pestis ail: multiple roles of a single protein. Front Cell Infect Microbiol 2:103CrossRefPubMedPubMedCentralGoogle Scholar
  26. Kukkonen M, Suomalainen M, Kyllönen P, Lähteenmäki K, Lång H, Virkola R, Helander IM, Holst O, Korhonen TK (2003) Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica. Mol Microbiol 51:215–225CrossRefGoogle Scholar
  27. Lahteenmaki K, Kukkonen M, Korhonen TK (2001) The Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cells. FEBS Lett 504:69–72CrossRefPubMedGoogle Scholar
  28. Lawrenz MB, Lenz JD, Miller VL (2009) A novel autotransporter adhesin is required for efficient colonization during bubonic plague. Infect Immun 77:317–326CrossRefPubMedGoogle Scholar
  29. Lindler LE, Tall BD (1993) Yersinia pestis pH 6 antigen forms a fimbria and is induced by intracellular association with macrophages. Mol Microbiol 8:311–324CrossRefPubMedGoogle Scholar
  30. Makoveichuk E, Cherepanov P, Lundberg S, Forsberg A, Olivecrona G (2003) pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes. J Lip Res 44:320–330CrossRefGoogle Scholar
  31. Marra A, Isberg RR (1997) Invasin-dependent and invasin-independent pathways for translocation of Yersinia pseudotuberculosis across the Peyer’s patch intestinal epithelium. Infect Immun 65:3412–3421PubMedPubMedCentralGoogle Scholar
  32. McNally A, La Ragione RM, Best A, Manning G, Newell DG (2007) An aflagellate mutant Yersinia enterocolitica biotype 1A strain displays altered invasion of epithelial cells, persistence in macrophages, and cytokine secretion profiles in vitro. Microbiology 153:1339–1349CrossRefPubMedGoogle Scholar
  33. Mikula KM, Kolodziejczyk R, Goldman A (2012) Yersinia infection tools-characterization of structure and function of adhesins. Front Cell Infect Microbiol 2:169PubMedGoogle Scholar
  34. Muhlenkamp M, Oberhettinger P, Leo JC, Linke D, Schutz MS (2015) Yersinia adhesin A (YadA) – beauty & beast. Int J Med Microbiol 305:252–258CrossRefPubMedGoogle Scholar
  35. Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ, Orth K (2006) Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science 312:1211–1214CrossRefPubMedGoogle Scholar
  36. Nair MK, De Masi L, Yue M, Galvan EM, Chen H, Wang F, Schifferli DM (2015) Adhesive properties of YapV and paralogous autotransporter proteins of Yersinia pestis. Infect Immun 83:1809–1819CrossRefPubMedPubMedCentralGoogle Scholar
  37. Nuss AM, Heroven AK, Dersch P (2017) RNA regulators: formidable modulators of Yersinia virulence. Trends Microbiol 25:19–34CrossRefPubMedGoogle Scholar
  38. Orth K, Xu Z, Mudgett MB, Bao ZQ, Palmer LE, Bliska JB, Mangel WF, Staskawicz B, Dixon JE (2000) Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science 290:1594–1597CrossRefPubMedGoogle Scholar
  39. Pakharukova N, Roy S, Tuittila M, Rahman MM, Paavilainen S, Ingars AK, Skaldin M, Lamminmaki U, Hard T, Teneberg S, Zavialov AV (2016) Structural basis for Myf and Psa fimbriae-mediated tropism of pathogenic strains of Yersinia for host tissues. Mol Microbiol 102:593–610CrossRefPubMedGoogle Scholar
  40. Palmer LE, Hobbie S, Galán JE, Bliska JB (1998) YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-alpha production and downregulation of the MAP kinases p38 and JNK. Mol Microbiol 27:953–965CrossRefPubMedGoogle Scholar
  41. Parkhill J, Wren BW, Thomson NR, Titball RW, Holden MTG, Prentice MB, Sebaihia M, James KD, Churcher C, Mungall KL, Baker S, Basham D, Bentley SD, Brooks K, Cerdeno-Tarraga AM, Chillingworth T, Cronin A, Davies RM, Davis P, Dougank G, Feltwell T, Hamlin N, Holroyd S, Jagels K, Karlyshev AV, Leather S, Moule S, Oyston PCF, Quail M, Rutherford K, Simmonds M, Skelton J, Stevens K, Whitehead S, Barrell BG (2001) Genome sequence of Yersinia pestis, the causative agent of plague. Nature 413:523–527CrossRefPubMedGoogle Scholar
  42. Pawel-Rammingen U, Telepnev MV, Schmidt G, Aktories K, Wolf-Watz H, Rosqvist R (2000) GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure. Mol Microbiol 36:737–748CrossRefGoogle Scholar
  43. Pechous RD, Sivaraman V, Stasulli NM, Goldman WE (2016) Pneumonic plague: the darker side of Yersinia pestis. Trends Microbiol 24:190–197CrossRefPubMedGoogle Scholar
  44. Perry RD, Fetherston JD (2011) Yersiniabactin iron uptake: mechanisms and role in Yersinia pestis pathogenesis. Microbes Infect 13:808–817CrossRefPubMedPubMedCentralGoogle Scholar
  45. Perry RD, Balbo PB, Jones HA, Fetherston JD, DeMoll E (1999) Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation. Microbiology 145:1181–1190CrossRefPubMedGoogle Scholar
  46. Philip NH, Zwack EE, Brodsky IE (2016) Activation and evasion of inflammasomes by Yersinia. Curr Top Microbiol Immunol 397:69–90PubMedGoogle Scholar
  47. Porcheron G, Schouler C, Dozois CM (2016) Survival games at the dinner table: regulation of Enterobacterial virulence through nutrient sensing and acquisition. Curr Opin Microbiol 30:98–106CrossRefPubMedGoogle Scholar
  48. Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E (2016) The Yersinia pestis effector YopM inhibits pyrin inflammasome activation. PLoS Pathog 12:e1006035CrossRefPubMedPubMedCentralGoogle Scholar
  49. Sauvonnet N, Lambermont I, van der Bruggen P, Cornelis GR (2002) YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathway. Mol Microbiol 45:805–815CrossRefPubMedGoogle Scholar
  50. Schulze-Koops H, Burkhardt H, Heesemann J, von der Mark K, Emmrich F (1992) Plasmid-encoded outer membrane protein YadA mediates specific binding of enteropathogenic yersiniae to various types of collagen. Infect Immun 60:2153–2159PubMedPubMedCentralGoogle Scholar
  51. Schweer J, Kulkarni D, Kochut A, Pezoldt J, Pisano F, Pils MC, Genth H, Huehn J, Dersch P (2013) The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases. PLoS Pathog 9:e1003746CrossRefPubMedPubMedCentralGoogle Scholar
  52. Thompson JM, Jones HA, Perry RD (1999) Molecular characterization of the hemin uptake locus (hmu) from Yersinia pestis and analysis of hmu mutants for hemin and hemoprotein utilization. Infect Immun 67:3879–3892PubMedPubMedCentralGoogle Scholar
  53. Thomson NR, Howard S, Wren BW, Holden MT, Crossman L, Challis GL, Churcher C, Mungall K, Brooks K, Chillingworth T, Feltwell T, Abdellah Z, Hauser H, Jagels K, Maddison M, Moule S, Sanders M, Whitehead S, Quail MA, Dougan G, Parkhill J, Prentice MB (2006) The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLoS Genet 2:e206CrossRefPubMedPubMedCentralGoogle Scholar
  54. Wagner NJ, Lin CP, Borst LB, Miller VL (2013) YaxAB, a Yersinia enterocolitica pore-forming toxin regulated by RovA. Infect Immun 81:4208–4219CrossRefPubMedPubMedCentralGoogle Scholar
  55. Wei C, Wang Y, Du Z, Guan K, Cao Y, Yang H, Zhou P, Wu F, Chen J, Wang P, Zheng Z, Zhang P, Zhang Y, Ma S, Yang R, Zhong H, He X (2016) The Yersinia type III secretion effector YopM is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3. Cell Death Dis 7:e2519CrossRefPubMedPubMedCentralGoogle Scholar
  56. Young VB, Miller VL, Falkow S, Schoolnik GK (1990) Sequence, localization and function of the invasin protein of Yersinia enterocolitica. Mol Microbiol 4:1119–1128CrossRefPubMedGoogle Scholar
  57. Young VB, Falkow S, Schoolnik GK (1992) The invasin protein of Yersinia enterocolitica: internalization of invasin-bearing bacteria by eukaryotic cells is associated with reorganization of the cytoskeleton. J Cell Biol 116:197–207CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Douglas I. Johnson
    • 1
  1. 1.Department of Microbiology & Molecular GeneticsUniversity of VermontBurlingtonUSA

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