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Treponema spp.

  • Douglas I. Johnson
Chapter

Abstract

  • Genomics:
    • Treponema pallidum chromosome: 1,138,006 bp; 1041 predicted ORFs (Fraser et al. 1998)

  • Cell morphology:
    • Thin (0.2 μm), long (6–15 μm) spirochete (Fig. 29.1):
      • Tightly coiled corkscrew shape (Charon et al. 2012)

      • Three to six endoflagella (axial filaments):
        • Anchored at both ends of the cell and run lengthwise between the inner and outer membranes in the periplasmic space; enclosed in outer sheath

        • Causes twisting motion used for motility; important for dissemination in host

        • Endoflagella subunits (Champion et al. 1990; Lafond and Lukehart 2006):
          • FlaB1, FlaB2, and FlaB3 – flagellar core

          • FlaA subunit – outer sheath

    • Outer membrane – very fragile:
      • No LPS (endotoxin)

      • Not tightly associated with underlying peptidoglycan and cellular membrane

  • Gram stain:
    • Gram negative: no LPS

  • Growth:
    • Anaerobic or microaerophilic growth; no catalases or oxidases

    • Slow grower (30–50 h doubling time); metabolically crippled:
      • No Kreb’s cycle or electron transport chain; gets ATP from glycolysis

      • No genes for synthesis of nucleotides, fatty acids, vitamins, cofactors, or amino acids; gets most of its nutrients through transport, not biosynthesis

    • Reservoir: humans (T. pallidum); survives poorly outside human host

    • At least 33 species – four Treponema pallidum subspecies and T. denticola are human pathogens:
      • T. pallidum subsp. pallidum: causes syphilis; sexually transmitted disease

      • T. pallidum subsp. endemicum: causes bejel (endemic syphilis); chronic disease of skin and tissues, usually found in arid environment

      • T. pallidum subsp. carateum: causes pinta; skin disease; usually found in Central America and South America

      • T. pallidum subsp. pertenue: causes yaws; non-sexually transmitted infection of skin, bones, and joints; usually found in the tropics

      • T. denticola: oral pathogen; periodontitis

References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Douglas I. Johnson
    • 1
  1. 1.Department of Microbiology & Molecular GeneticsUniversity of VermontBurlingtonUSA

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