Campylobacter spp.

  • Douglas I. Johnson


  • Genomics:
    • Campylobacter jejuni chromosome: 1,641,481 bp; 1,643 predicted ORFs (Gundogdu et al. 2007; Parkhill et al. 2000)

    • Plasmid pVir: 37,468 bp; 54 predicted ORFs (Bacon et al. 2002)

  • Cell morphology:
    • Curved or spiral bacilli; “twisted bacteria” (Fig. 14.1)

    • Lipooligosaccharide (LOS, rough LPS) outer membrane:
      • Highly variable sialylated structures; plays a role in immune avoidance (Guerry et al. 2000).

      • Some structures resemble human neuronal gangliosides – molecular mimicry can lead to autoimmune reactions (Bowes et al. 2002; Yuki 2001).
        • For example, Guillain–Barré Syndrome occurs in ~1 out of 1,000 cases of campylobacteriosis (Godschalk et al. 2004).

    • Capsule (Karlyshev et al. 2005):
      • Highly variable polysaccharides

      • Plays a role in adherence to host cells and anti-phagocytosis immune evasion

    • Flagella:
      • Either monopolar or bipolar.

      • Composed of FlaA (major) and FlaB (minor) flagellin subunits; undergo phase variation and antigen variation – evasion of host immune system.

      • Contain significant levels of O-linked glycosylation; important for assembly and adherence to host intestinal epithelial cells.

      • Flagellar movement through the mucus layer plays an essential role in colonization and virulence.

      • Flagellar type 3 secretion system (T3SS):
        • Functions in the secretion of bacterial effectors, such as FlaC (Song et al. 2004) and Campylobacter invasive antigen (Cia) proteins (Grant et al. 1993; Konkel et al. 2004) (see below)


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Douglas I. Johnson
    • 1
  1. 1.Department of Microbiology & Molecular GeneticsUniversity of VermontBurlingtonUSA

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