Cold Atmospheric Plasma (CAP) Combined with Chemo-Radiation and Cytoreductive Surgery: The First Clinical Experience for Stage IV Metastatic Colon Cancer

  • Jerome Canady
  • Steven Gordon
  • Taisen Zhuang
  • Shruti Wigh
  • Warren Rowe
  • Alexey Shashurin
  • Dereck Chiu
  • Sterlyn Jones
  • Kimberly Wiley
  • Emil Cohen
  • Tammy Naab
  • Barry Trink
  • Victor Priego
  • Anu Gupta
  • Giacomo Basadonna
  • Robert Dewitty
  • Michael Keidar
Chapter

Abstract

The authors report the first clinical experience using CAP for Stage IV metastatic colon cancer. The report describes the patient’s history, chemotherapy, radiation, surgical treatment and ex-vivo and intra-operative treatment of the tumor and normal tissue with CAP. Evaluation of intra-operative temperature, oxygen and end tidal CO2 measurements during the surgery and post-surgery analysis of tissue treated by cold plasma. In vivo studies suggest that TRAIl-R1 expression increases in the CAP treated liver tissues, suggesting that the death receptor molecule may be involved in inducing apoptosis. Three-month postoperative CT scan of the abdomen and pelvis revealed no evidence of recurrent tumor at the resected and cold plasma treatment sites.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Jerome Canady
    • 1
    • 2
    • 3
  • Steven Gordon
    • 4
  • Taisen Zhuang
    • 2
  • Shruti Wigh
    • 2
  • Warren Rowe
    • 1
  • Alexey Shashurin
    • 1
    • 5
  • Dereck Chiu
    • 2
  • Sterlyn Jones
    • 1
  • Kimberly Wiley
    • 1
  • Emil Cohen
    • 6
  • Tammy Naab
    • 7
  • Barry Trink
    • 8
  • Victor Priego
    • 9
  • Anu Gupta
    • 10
  • Giacomo Basadonna
    • 1
    • 11
  • Robert Dewitty
    • 1
    • 7
  • Michael Keidar
    • 1
    • 5
  1. 1.Jerome Canady Research Institute for Advanced Biological and Technological Sciences, Translational and Molecular CenterTakoma ParkUSA
  2. 2.Plasma Medicine Life SciencesTakoma ParkUSA
  3. 3.Department of Mechanical and Aerospace Engineering, School of Engineering and Applied ScienceThe George Washington UniversityWashington, DCUSA
  4. 4.Department of SurgeryBaton Rouge General Hospital (Bluebonnet)Baton RougeUSA
  5. 5.George Washington UniversityWashington, DCUSA
  6. 6.Department of RadiologyWashington Hospital CenterWashington, DCUSA
  7. 7.Department of Pathology and SurgeryHoward University HospitalWashington, DCUSA
  8. 8.Department of OtolaryngologyRambam Medical CenterHaifaIsrael
  9. 9.Medical Oncology SectionCancer for Center and Blood DisorderBethesdaUSA
  10. 10.Cancer Center @ Gaithersburg, Radiation OncologyGaithersburgUSA
  11. 11.Department of SurgeryUniversity of Massachusetts School of MedicineWorcesterUSA

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