Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies
Regulation of cell growth and proliferation is crucial for development and function of organs in all animals. Genetic defects in growth control can lead to developmental disorders and cancers. Translationally controlled tumor protein (TCTP) is a family of evolutionarily conserved proteins implicated in cancer. Recent studies have revealed multiple roles of TCTP in diverse cellular events, but TCTP functions in vivo are poorly understood in vertebrate systems. We have used Drosophila melanogaster, the fruit fly, as a model organism for genetic dissection of Tctp function. Our studies have shown that Tctp is essential for organ development by regulating growth signaling. Furthermore, it is required for genome stability by promoting DNA repair and chromatin remodeling in the nucleus. Thus, Tctp acts as a multifaceted cytosolic and nuclear factor for regulating organ growth and genome stability. In this chapter, we describe an overview of our findings on Tctp functions in Drosophila and discuss their implications in cancer.
We thank Kyungok Cho and Jean Jung for comments on the manuscript. This work was supported by NRF-2014K1A1A2042982, NRF-2017R1A2B3007516 (KWC), 2016R1D1A1B03932093 and 35B-2011-1-C00033 (STH) through the National Research Foundation of Korea funded by the Korean Ministry of Education Science & Technology.
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