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Role and Fate of TCTP in Protein Degradative Pathways

  • Michel VidalEmail author
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 64)

Abstract

This chapter focuses on published studies specifically concerning TCTP and its involvement in degradation or stabilization of various proteins, and also in its own degradation in different ways. The first part relates to the inhibition of proteasomal degradation of proteins. This can be achieved by masking ubiquitination sites of specific partners, by favoring ubiquitin E3 ligase degradation, or by regulating proteasome activity. The second part addresses the ability of TCTP to favor degradation of specific proteins through proteasome or macroautophagic pathways. The third part discusses about the different ways by which TCTP has been shown to be degraded.

Abbreviations

Bre5

Brefeldin A sensitivity 5

CMA

Chaperone-mediated autophagy

DHA

Dihydroartemisinin

HIF1α

Hypoxia-inducible factor 1α

HRF

Histamine releasing factor

Hsp27

Heat shock protein 27

Mcl-1

Myeloid cell leukemia 1

Mdm2

Murine double minute 2

Mmi1

Microtubule and mitochondria interacting protein

Mss4

Mammalian suppressor of yeast Sec4

Mst-1

Mammalian sterile twenty-1

NTHK1

Tobacco histidine kinase-1

Pim-3

Serine/threonine-protein kinase Pim-3

PRX1

Peroxiredoxin-1

Rpn

26S proteasome regulatory subunit

Rpt

Proteasome regulatory particle base subunit

UPS

Ubiquitin–proteasome system

TCTP

Translationally controlled tumor protein

Ubp3

ubiquitin specific protease 3

VHL

von Hippel–Lindau protein

Notes

Acknowledgements

This work was supported by grants from the CNRS, the University of Montpellier, and from the Labex LERMIT.

Compliance with Ethics Guidelines

The author declares that he has no conflict of interest with the contents of this chapter.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Université MontpellierMontpellierFrance

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