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Training Deep Convolutional Neural Networks with Active Learning for Exudate Classification in Eye Fundus Images

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Intravascular Imaging and Computer Assisted Stenting, and Large-Scale Annotation of Biomedical Data and Expert Label Synthesis (LABELS 2017, STENT 2017, CVII 2017)

Abstract

Training deep convolutional neural network for classification in medical tasks is often difficult due to the lack of annotated data samples. Deep convolutional networks (CNN) has been successfully used as an automatic detection tool to support the grading of diabetic retinopathy and macular edema. Nevertheless, the manual annotation of exudates in eye fundus images used to classify the grade of the DR is very time consuming and repetitive for clinical personnel. Active learning algorithms seek to reduce the labeling effort in training machine learning models. This work presents a label-efficient CNN model using the expected gradient length, an active learning algorithm to select the most informative patches and images, converging earlier and to a better local optimum than the usual SGD (Stochastic Gradient Descent) strategy. Our method also generates useful masks for prediction and segments regions of interest.

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Notes

  1. 1.

    http://www.who.int/diabetes/en/.

  2. 2.

    https://www.kaggle.com/c/diabetic-retinopathy-detection.

References

  1. Decencière, E., Cazuguel, G., Zhang, X., Thibault, G., Klein, J.C., Meyer, F., Marcotegui, B., Quellec, G., Lamard, M., Danno, R., et al.: Teleophta: machine learning and image processing methods for teleophthalmology. IRBM 34(2), 196–203 (2013)

    Article  Google Scholar 

  2. Freytag, A., Rodner, E., Denzler, J.: Selecting influential examples: active learning with expected model output changes. In: Fleet, D., Pajdla, T., Schiele, B., Tuytelaars, T. (eds.) ECCV 2014. LNCS, vol. 8692, pp. 562–577. Springer, Cham (2014). doi:10.1007/978-3-319-10593-2_37

    Google Scholar 

  3. Greenspan, H., van Ginneken, B., Summers, R.M.: Guest editorial deep learning in medical imaging: overview and future promise of an exciting new technique. IEEE Trans. Med. Imaging 35(5), 1153–1159 (2016)

    Article  Google Scholar 

  4. Gulshan, V., Peng, L., Coram, M., Stumpe, M.C., Wu, D., Narayanaswamy, A., Venugopalan, S., Widner, K., Madams, T., Cuadros, J., et al.: Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA 316(22), 2402–2410 (2016)

    Article  Google Scholar 

  5. Jia, Y., Shelhamer, E., Donahue, J., Karayev, S., Long, J., Girshick, R., Guadarrama, S., Darrell, T.: Caffe: convolutional architecture for fast feature embedding. In: Proceedings of the 22nd ACM International Conference on Multimedia, pp. 675–678. ACM (2014)

    Google Scholar 

  6. Kauppi, T., et al.: Eye fundus image analysis for automatic detection of diabetic retinopathy. Lappeenranta University of Technology (2010)

    Google Scholar 

  7. LeCun, Y., Bottou, L., Bengio, Y., Haffner, P.: Gradient-based learning applied to document recognition. Proc. IEEE 86(11), 2278–2324 (1998)

    Article  Google Scholar 

  8. Perdomo, O., Otalora, S., Rodríguez, F., Arevalo, J., González, F.A.: A novel machine learning model based on exudate localization to detect diabetic macular edema. In: Ophthalmic Medical Image Analysis Third International Workshop (OMIA 2016), pp. 137–144. University of Iowa (2016)

    Google Scholar 

  9. Sánchez, C.I., Niemeijer, M., Abràmoff, M.D., van Ginneken, B.: Active learning for an efficient training strategy of computer-aided diagnosis systems: application to diabetic retinopathy screening. In: Jiang, T., Navab, N., Pluim, J.P.W., Viergever, M.A. (eds.) MICCAI 2010. LNCS, vol. 6363, pp. 603–610. Springer, Heidelberg (2010). doi:10.1007/978-3-642-15711-0_75

    Chapter  Google Scholar 

  10. Settles, B.: Active learning literature survey. Univ. Wis. Madison 52(55–66), 11 (2010)

    Google Scholar 

  11. Settles, B., Craven, M., Ray, S.: Multiple-instance active learning. In: Advances in Neural Information Processing Systems, pp. 1289–1296 (2008)

    Google Scholar 

  12. Stitt, A.W., Lois, N., Medina, R.J., Adamson, P., Curtis, T.M.: Advances in our understanding of diabetic retinopathy. Clin. Sci. 125(1), 1–17 (2013)

    Article  Google Scholar 

  13. Yu, F., Seff, A., Zhang, Y., Song, S., Funkhouser, T., Xiao, J.: LSUN: construction of a large-scale image dataset using deep learning with humans in the loop. arXiv preprint arXiv:1506.03365 (2015)

  14. Zhou, S., Chen, Q., Wang, X.: Active semi-supervised learning method with hybrid deep belief networks. PLoS ONE 9(9), e107122 (2014)

    Article  Google Scholar 

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Acknowledgments

This work was supported by the Administrative Department of Science, Technology and Innovation of Colombia (Colciencias) through the grant Jóvenes Investigadores 2014 in call 645 and by Nvidia with a TitanX GPU.

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Correspondence to Sebastian Otálora .

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Otálora, S., Perdomo, O., González, F., Müller, H. (2017). Training Deep Convolutional Neural Networks with Active Learning for Exudate Classification in Eye Fundus Images. In: Cardoso, M., et al. Intravascular Imaging and Computer Assisted Stenting, and Large-Scale Annotation of Biomedical Data and Expert Label Synthesis. LABELS STENT CVII 2017 2017 2017. Lecture Notes in Computer Science(), vol 10552. Springer, Cham. https://doi.org/10.1007/978-3-319-67534-3_16

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  • DOI: https://doi.org/10.1007/978-3-319-67534-3_16

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