Skip to main content

D-Looped Transposition of the Great Arteries

  • Chapter
  • First Online:
Adult Congenital Heart Disease in Clinical Practice

Part of the book series: In Clinical Practice ((ICP))

  • 1022 Accesses

Abstract

Dextro- or D-looped transposition of the great arteries (D-TGA) has a reported birth incidence of 0.3/1000 patients. It is the most common cause of cyanosis in newborns [1, 2]. Whereas overall survival of patients with the Mustard or Senning atrial switch procedure is 75% at 25 years, the arterial switch procedure is now the standard of care in infancy. Long term complications of both types of surgical correction are outlined in detail.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Defaria Yeh D, Liberthson R, Bhatt A. Adult congenital heart disease. In: Gaggin HK, Januzzi JL, editors. Massachusetts General Hospital Cardiology Board Review: Springer; 2014. p. 345–77.

    Google Scholar 

  2. Bernier PL, Stefanescu A, Samoukovic G, Tchervenkov CI. The challenge of congenital heart disease worldwide: epidemiologic and demographic facts. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2010;13:26–34.

    Article  PubMed  Google Scholar 

  3. Warnes CA, Williams RG, Bashore TM, et al. ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease). Circulation. 2008;118:e714–833.

    PubMed  Google Scholar 

  4. Pasquini L, Sanders SP, Parness IA, et al. Coronary echocardiography in 406 patients with d-loop transposition of the great arteries. J Am Coll Cardiol. 1994;24:763–8.

    Article  CAS  PubMed  Google Scholar 

  5. Senning A. Surgical correction of transposition of the great vessels. Surgery. 1959;45:966–80.

    CAS  PubMed  Google Scholar 

  6. Mustard WT. Successful two-stage correction of transposition of the great vessels. Surgery. 1964;55:469–72.

    CAS  PubMed  Google Scholar 

  7. DeFaria Yeh D, King ME. Congenital heart disease in the adult: what should the adult cardiologist know? Curr Cardiol Rep. 2015;17:25.

    Article  PubMed  Google Scholar 

  8. Kammeraad JA, van Deurzen CH, Sreeram N, et al. Predictors of sudden cardiac death after Mustard or Senning repair for transposition of the great arteries. J Am Coll Cardiol. 2004;44:1095–102.

    Article  PubMed  Google Scholar 

  9. Khairy P. Ventricular arrhythmias and sudden cardiac death in adults with congenital heart disease. Heart. 2016;102(21):1703–9.

    Article  PubMed  Google Scholar 

  10. Stefanescu A, DeFaria Yeh D, Dudzinski DM. Heart failure in adult congenital heart disease. Curr Treat Options Cardiovasc Med. 2014;16:337.

    Article  PubMed  Google Scholar 

  11. Therrien J, Provost Y, Harrison J, Connelly M, Kaemmerer H, Webb GD. Effect of angiotensin receptor blockade on systemic right ventricular function and size: a small, randomized, placebo-controlled study. Int J Cardiol. 2008;129:187–92.

    Article  PubMed  Google Scholar 

  12. Hechter SJ, Fredriksen PM, Liu P, et al. Angiotensin-converting enzyme inhibitors in adults after the Mustard procedure. Am J Cardiol. 2001;87:660–3, A11.

    Article  CAS  PubMed  Google Scholar 

  13. Lester SJ, McElhinney DB, Viloria E, et al. Effects of losartan in patients with a systemically functioning morphologic right ventricle after atrial repair of transposition of the great arteries. Am J Cardiol. 2001;88:1314–6.

    Article  CAS  PubMed  Google Scholar 

  14. Dore A, Houde C, Chan KL, et al. Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial. Circulation. 2005;112:2411–6.

    Article  CAS  PubMed  Google Scholar 

  15. Tutarel O, Meyer GP, Bertram H, Wessel A, Schieffer B, Westhoff-Bleck M. Safety and efficiency of chronic ACE inhibition in symptomatic heart failure patients with a systemic right ventricle. Int J Cardiol. 2012;154:14–6.

    Article  PubMed  Google Scholar 

  16. Van der Bom T, Winter MM, Bouma BJ, et al. Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial. Circulation. 2013;127:322–30.

    Article  PubMed  Google Scholar 

  17. Giardini A, Lovato L, Donti A, et al. A pilot study on the effects of carvedilol on right ventricular remodelling and exercise tolerance in patients with systemic right ventricle. Int J Cardiol. 2007;114:241–6.

    Article  PubMed  Google Scholar 

  18. Dubin AM, Janousek J, Rhee E, et al. Resynchronization therapy in pediatric and congenital heart disease patients: an international multicenter study. J Am Coll Cardiol. 2005;46:2277–83.

    Article  PubMed  Google Scholar 

  19. Khairy P, Van Hare GF, Balaji S, et al. PACES/HRS expert consensus statement on the recognition and management of arrhythmias in adult congenital heart disease: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology (ACC), the American Heart Association (AHA), the European Heart Rhythm Association (EHRA), the Canadian Heart Rhythm Society (CHRS), and the International Society for Adult Congenital Heart Disease (ISACHD). Can J Cardiol. 2014;30:e1–e63.

    Article  PubMed  Google Scholar 

  20. Canobbio MM, Morris CD, Graham TP, Landzberg MJ. Pregnancy outcomes after atrial repair for transposition of the great arteries. Am J Cardiol. 2006;98:668–72.

    Article  PubMed  Google Scholar 

  21. Canobbio MM, Warnes CA, Aboulhosn J, et al. Management of pregnancy in patients with complex congenital heart disease: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2017;135(8):e50–87.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ada C. Stefanescu Schmidt M.D., M.Sc. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Stefanescu Schmidt, A.C. (2018). D-Looped Transposition of the Great Arteries. In: DeFaria Yeh, D., Bhatt, A. (eds) Adult Congenital Heart Disease in Clinical Practice. In Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-67420-9_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-67420-9_25

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67418-6

  • Online ISBN: 978-3-319-67420-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics