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3D Printing of Pharmaceuticals

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Micro and Nanomanufacturing Volume II

Abstract

In the new era of medicine, 3D printing technique in pharmaceutical manufacturing has already yielded success. For example, Aprecia®, an FDA-approved pharmaceutical company, has launched its first approved product which is not only unique because of a novel manufacturing process but also better than conventional compressed tablets. 3D printing is an inexpensive additive manufacturing technique that builds a 3D object by successive layering on top of each other in a 2D fashion. The layering of the object in process is controlled digitally in a computer-aided design (CAD). 3D printing of pharmaceuticals suits best for personalised therapy, not only in case of doses but dosage form as well. A personalised dosage form can be designed and printed in such a way that the drugs are combined in a single pill (polypill). This cannot only make the therapy and schedule convenient for patient but also increase adherence.

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References

  1. Melchels FPW, Feijen J, Grijpma DW (2010) A review on stereolithography and its applications in biomedical engineering. Biomaterials 31(24):6121–6130

    Article  Google Scholar 

  2. Khaled SA et al (2015) 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. J Control Release 217:308–314

    Article  Google Scholar 

  3. Garber AJ et al (2003) Efficacy of glyburide/metformin tablets compared with initial monotherapy in type 2 diabetes. J Clin Endocrinol Metab 88(8):3598–3604

    Article  Google Scholar 

  4. Murphy SV, Atala A (2014) 3D bioprinting of tissues and organs. Nat Biotechnol 32(8):773–785

    Article  Google Scholar 

  5. CSC Leading Edge Forum (2012) 3D printing and the future of manufacturing. FALL. 36.

    Google Scholar 

  6. Deckard CR (1989) Method and apparatus for producing parts by selective sintering. Google Patents.

    Google Scholar 

  7. Crump SS (1992) Apparatus and method for creating three-dimensional objects. Google Patents.

    Google Scholar 

  8. Hull CW et al. (1994) Method and apparatus for production of high resolution three-dimensional objects by stereolithography. Google Patents.

    Google Scholar 

  9. Verma A, Rai R (2013) Energy efficient modeling and optimization of additive manufacturing processes. In solid freeform fabrication symposium, Austin, TX.

    Google Scholar 

  10. Leong KF et al (2001) Fabrication of porous polymeric matrix drug delivery devices using the selective laser sintering technique. Proc Inst Mech Eng H 215(2):191–201

    Article  Google Scholar 

  11. Jacob J (2014) et al. Rapid disperse dosage form containing levetiracetam. Google Patents.

    Google Scholar 

  12. Katstra WE et al (2000) Oral dosage forms fabricated by three dimensional printing. J Control Release 66(1):1–9

    Article  Google Scholar 

  13. Rowe CW et al (2000) Multimechanism oral dosage forms fabricated by three dimensional printing. J Control Release 66(1):11–17

    Article  Google Scholar 

  14. Chia HN, Wu BM (2015) Recent advances in 3D printing of biomaterials. J Biol Eng 9:4

    Article  Google Scholar 

  15. Khaled SA et al (2014) Desktop 3D printing of controlled release pharmaceutical bilayer tablets. Int J Pharm 461(1–2):105–111

    Article  Google Scholar 

  16. Skowyra J, Pietrzak K, Alhnan MA (2015) Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. Eur J Pharm Sci 68:11–17

    Article  Google Scholar 

  17. Pietrzak K, Isreb A, Alhnan MA (2015) A flexible-dose dispenser for immediate and extended release 3D printed tablets. Eur J Pharm Biopharm 96:380–387

    Article  Google Scholar 

  18. Melocchi A et al (2015) 3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs. J Drug Deliv Sci Technol 30(Part B):360–367

    Article  Google Scholar 

  19. Wang J et al (2016) Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. Int J Pharm 503(1–2):207–212

    Article  Google Scholar 

  20. Wang C-C et al (2006) Development of near zero-order release dosage forms using three-dimensional printing (3-DP™) technology. Drug Dev Ind Pharm 32(3):367–376

    Article  Google Scholar 

  21. Huang W et al (2007) Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique. Int J Pharm 339(1–2):33–38

    Article  Google Scholar 

  22. Yu DG et al (2009) Novel drug delivery devices for providing linear release profiles fabricated by 3DP. Int J Pharm 370(1–2):160–166

    Article  Google Scholar 

  23. Yu DG et al (2009) Novel oral fast-disintegrating drug delivery devices with predefined inner structure fabricated by three-dimensional printing. J Pharm Pharmacol 61(3):323–329

    Article  Google Scholar 

  24. Wu BM et al (1996) Solid free-form fabrication of drug delivery devices. J Control Release 40(1–2):77–87

    Article  Google Scholar 

  25. Khaled SA et al (2015) 3D printing of tablets containing multiple drugs with defined release profiles. Int J Pharm 494(2):643–650

    Article  Google Scholar 

  26. Goyanes A et al (2015) 3D printing of medicines: engineering novel oral devices with unique design and drug release characteristics. Mol Pharm 12(11):4077–4084

    Article  Google Scholar 

  27. Goyanes A et al (2015) Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing. Int J Pharm 496(2):414–420

    Article  Google Scholar 

  28. Goyanes A et al (2014) Fused-filament 3D printing (3DP) for fabrication of tablets. Int J Pharm 476(1–2):88–92

    Article  Google Scholar 

  29. Goyanes A et al (2015) 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. Eur J Pharm Biopharm 89:157–162

    Article  Google Scholar 

  30. Goyanes A et al (2015) Effect of geometry on drug release from 3D printed tablets. Int J Pharm 494(2):657–663

    Article  Google Scholar 

  31. Water JJ et al (2015) Three-dimensional printing of drug-eluting implants: preparation of an antimicrobial polylactide feedstock material. J Pharm Sci 104(3):1099–1107

    Article  Google Scholar 

  32. Weisman JA et al (2015) Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications. Int J Nanomedicine 10:357–370

    Google Scholar 

  33. Sun Y, Soh S (2015) Printing tablets with fully customizable release profiles for personalized medicine. Adv Mater 27(47):7847–7853

    Article  Google Scholar 

  34. Alhijjaj M, Belton P, Qi S (2016) An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing. Eur J Pharm Biopharm 108:111–125

    Article  Google Scholar 

  35. Okwuosa TC et al (2016) A lower temperature FDM 3D printing for the manufacture of patient-specific immediate release tablets. Pharm Res 33(11):2704–2712

    Article  Google Scholar 

  36. Okwuosa TC et al (2017) Fabricating a shell-core delayed release tablet using dual FDM 3D printing for patient-Centred therapy. Pharm Res 34(2):427–437

    Article  Google Scholar 

  37. Sadia M et al (2016) Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets. Int J Pharm 513(1–2):659–668

    Article  Google Scholar 

  38. Zhang J et al (2017) Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets. Int J Pharm 519(1–2):186–197

    Article  Google Scholar 

  39. Goyanes A et al (2017) Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing. Int J Pharm 527(1–2):21–30

    Article  Google Scholar 

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Authors and Affiliations

  1. School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK

    Muzna Sadia & Mohamed Albed Alhnan

  2. School of Mathematics and Physics, University of Lincoln, Lincoln, UK

    Waqar Ahmed

  3. School of Interdisciplinary Studies, Kansas State University, Manhattan, KS, USA

    Mark J. Jackson

Authors
  1. Muzna Sadia
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  2. Mohamed Albed Alhnan
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  3. Waqar Ahmed
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  4. Mark J. Jackson
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Corresponding author

Correspondence to Muzna Sadia .

Editor information

Editors and Affiliations

  1. School of Interdisciplinary Studies, Kansas State University, Manhattan, Kansas, USA

    Mark J. Jackson

  2. School of Mathematics and Physics, University of Lincoln, Lincoln, United Kingdom

    Waqar Ahmed

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Sadia, M., Alhnan, M.A., Ahmed, W., Jackson, M.J. (2018). 3D Printing of Pharmaceuticals. In: Jackson, M., Ahmed, W. (eds) Micro and Nanomanufacturing Volume II. Springer, Cham. https://doi.org/10.1007/978-3-319-67132-1_16

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  • DOI: https://doi.org/10.1007/978-3-319-67132-1_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67130-7

  • Online ISBN: 978-3-319-67132-1

  • eBook Packages: EngineeringEngineering (R0)

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