Omics in Forensic Toxicology a Bridge Towards Forensic Medicine

  • Nasim Bararpour
  • Frank Sporkert
  • Marc Augsburger
  • Aurélien Thomas
Chapter

Abstract

Cutting-edge omic strategies are bringing new opportunities to many fields of investigation from the biomedical to the biomedicolegal. Comprehension of molecular mechanisms associated with pathologies such as acute or chronic toxicity or sudden cardiac death and the discovery of associated biomarkers represent key elements in the development of novel routes for a better understanding of complex phenomena. Omics and mining of complex generated data have reached a state of maturity. Recent innovations, notably for mass spectrometry with a remarkable gain in sensitivity and selectivity, and the development of next-generation sequencing technologies, have considerably increased the power of these approaches. In spite of ongoing progress in the omic methodologies, their application can already provide informative results leading to more accurate interpretations and evidences. Beyond the remarkable potential in forensic toxicology such as the research of new biomarkers, we predict that these technologies will reinforce translational research between forensic and clinical disciplines.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  • Nasim Bararpour
    • 1
    • 2
  • Frank Sporkert
    • 1
  • Marc Augsburger
    • 1
  • Aurélien Thomas
    • 1
    • 3
  1. 1.Unit of ToxicologyUniversity Center of Legal MedicineLausanne-GenevaSwitzerland
  2. 2.GenevaSwitzerland
  3. 3.Faculty of Biology and Medicine, Lausanne University HospitalUniversity of LausanneLausanneSwitzerland

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