Natural Products as Antiparasitic Agents

  • Lucie Paloque
  • Asih Triastuti
  • Geneviève Bourdy
  • Mohamed Haddad
Part of the Sustainable Development and Biodiversity book series (SDEB, volume 19)


Parasitic diseases remain a major burden on global human and veterinary health. They affect more than two billion people worldwide causing considerable morbidity and mortality and are a major constraint on livestock production, especially in the world’s poorest communities. The immense suffering caused by these illnesses and the consequential loss of productivity is a major drain on the limited resources of the populations in which they occur. Most modern and effective drugs for parasitic diseases present no financial viability for the pharmaceutical industry since affected people have limited financial resources. Although financial return on investment is insufficient for drug discovery process and development, there is a constant desperate need for new chemical entities presenting new mechanisms of action. Higher plants, marine organisms, and microorganisms provide immense opportunities for the discovery of new drugs and drug leads. The screening of these natural sources thus remains one of the most attractive routes to discovering and developing new drugs. This article reviews the importance of natural products as a source of antiparasitic drugs and discusses some of the research challenges.


Natural products Antimicrobial Human/animal parasitic disease Drug discovery 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Lucie Paloque
    • 1
  • Asih Triastuti
    • 2
  • Geneviève Bourdy
    • 2
  • Mohamed Haddad
    • 2
  1. 1.UPR8241 CNRS Laboratoire de Chimie de Coordination, University of Toulouse 3ToulouseFrance
  2. 2.UMR 152, IRD-UPS Pharma-DEV, University of Toulouse 3ToulouseFrance

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