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Natural Products from Plants as Potential Leads as Novel Antileishmanials: A Preclinical Review

  • João Henrique G. Lago
  • Kaidu H. Barrosa
  • Samanta Etel T. Borborema
  • André G. Tempone
Chapter
Part of the Sustainable Development and Biodiversity book series (SDEB, volume 19)

Abstract

Different plant species have been used in the folk medicine to the treatment of several pathologies. In some poor regions of the world, the use of these extracts is the unique therapeutic source for the treatment of antiparasitic diseases, including leishmaniasis. The effects of these extracts are directly associated to the production and accumulation of specific active natural products/secondary metabolites—terpenoids, phenolic derivatives, alkaloids, lignoids. Several studies have been conducted for evaluation of in vitro antileishmanial activity of these compounds but there are only few reports that describe the preclinical evaluation. In this aspect, this chapter attempts to give an overview on the potential of such plant-derived natural products as antileishmanial leads, mainly those that displayed in vivo potential.

Keywords

Leishmaniasis Natural products Plants In vivo assays Therapy Leishmania 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • João Henrique G. Lago
    • 1
  • Kaidu H. Barrosa
    • 1
  • Samanta Etel T. Borborema
    • 2
  • André G. Tempone
    • 2
  1. 1.Center for Natural and Human SciencesFederal University of ABCSanto AndreBrazil
  2. 2.Centre of Parasitology, Adolfo Lutz InstituteSão PauloBrazil

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