Case of a Girl with Irregular Periods, Acne, and Hirsutism
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and ovarian dysfunction, with multiple coexistent criteria suggested for defining the syndrome. Diagnosis of PCOS should only be made after excluding other diagnoses, especially in adolescents in whom pubertal and perimenarchal physiology may overlap with some findings of PCOS. Therapy for PCOS in adolescents should be tailored to amelioration of symptoms, preservation of fertility, prevention of uterine cancer, and, if present, reduction in insulin resistance to prevent associated comorbidities.
KeywordsPCOS Polycystic ovary syndrome Oligomenorrhea Hirsutism Hyperandrogenism Testosterone Oligo-anovulation Insulin resistance
- 1.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25.Google Scholar
- 2.Witchel SF, Oberfield S, Rosenfield RL, et al. The diagnosis of polycystic ovary syndrome during adolescence. Horm Res Paediatr. 2015.Google Scholar
- 7.Zawadzki J, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, editors. Polycystic ovary syndrome, vol. 4. Boston: Blackwell Scientific Publications; 1992. p. 377–84.Google Scholar