Case of a Girl with Irregular Periods, Acne, and Hirsutism


Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and ovarian dysfunction, with multiple coexistent criteria suggested for defining the syndrome. Diagnosis of PCOS should only be made after excluding other diagnoses, especially in adolescents in whom pubertal and perimenarchal physiology may overlap with some findings of PCOS. Therapy for PCOS in adolescents should be tailored to amelioration of symptoms, preservation of fertility, prevention of uterine cancer, and, if present, reduction in insulin resistance to prevent associated comorbidities.


PCOS Polycystic ovary syndrome Oligomenorrhea Hirsutism Hyperandrogenism Testosterone Oligo-anovulation Insulin resistance 


  1. 1.
    Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25.Google Scholar
  2. 2.
    Witchel SF, Oberfield S, Rosenfield RL, et al. The diagnosis of polycystic ovary syndrome during adolescence. Horm Res Paediatr. 2015.Google Scholar
  3. 3.
    Corvol P, Michaud A, Menard J, Freifeld M, Mahoudeau J. Antiandrogenic effect of spirolactones: mechanism of action. Endocrinology. 1975;97:52–8.CrossRefGoogle Scholar
  4. 4.
    Azziz R, Carmina E, Dewailly D, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 2009;91:456–88.CrossRefGoogle Scholar
  5. 5.
    Carmina E, Oberfield SE, Lobo RA. The diagnosis of polycystic ovary syndrome in adolescents. Am J Obstet Gynecol. 2010;203:201.e1–5.CrossRefGoogle Scholar
  6. 6.
    Fauser BC, Tarlatzis BC, Rebar RW, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 2012;97:28–38.e25.CrossRefGoogle Scholar
  7. 7.
    Zawadzki J, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, editors. Polycystic ovary syndrome, vol. 4. Boston: Blackwell Scientific Publications; 1992. p. 377–84.Google Scholar
  8. 8.
    Witchel SF, Roumimper H, Oberfield S. Polycystic ovary syndrome in adolescents. Endocrinol Metab Clin N Am. 2016;45:329–44.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of Pediatric Endocrinology, Department of PediatricsUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  2. 2.University of WisconsinAdolescent PCOS Clinic, American Family Children’s HospitalMadisonUSA

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