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Outcomes of Comorbidities with Biologic and Systemic Agents

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Biologic and Systemic Agents in Dermatology

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Abstract

Psoriasis is a chronic inflammatory disease and those with severe disease have higher rates of cardiometabolic comorbidities including major adverse cardiovascular events and death. Evidence from large observational studies suggests that treatment with both methotrexate and TNF inhibitors may reduce the risk of major cardiovascular events in those with severe disease. Further research is needed to understand how newer biologics (IL 12/23 inhibitors, IL-17 inhibitors) alter cardiovascular disease outcomes and cardiometabolic risk factors. Additionally, prospective randomized control trials are necessary to better understand the effect of systemic therapies on the incidence of major cardiovascular events.

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Abbreviations

CHF:

Congestive heart failure

CI:

Confidence interval

CRP:

C-reactive protein

HDL:

High-density lipoprotein

IL:

Interleukin

LDL:

Low-density lipoprotein

MACE:

Major adverse cardiovascular event

MI:

Myocardial infarction

MTX:

Methotrexate

NR:

Not reported

RA:

Rheumatoid arthritis

RCT:

Randomized control trial

TCI:

T-cell inhibitors (efalizumab, alefacept)

TNFi:

Tumor necrosis factor alpha inhibitor

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Authors and Affiliations

  1. Department of Dermatology, University of Pennsylvania, 3400 Civic Center Blvd, South Tower, Office 773, Philadelphia, PA, 19104, USA

    Megan H. Noe MD, MPH

  2. Department of Dermatology, University of Pennsylvania, 3400 Civic Center Blvd, South Tower, Office 730, Philadelphia, PA, 19104, USA

    Joel M. Gelfand MD, MSCE

Authors
  1. Megan H. Noe MD, MPH
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  2. Joel M. Gelfand MD, MSCE
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Correspondence to Joel M. Gelfand MD, MSCE .

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Editors and Affiliations

  1. Division of Dermatology, David Geffen School of Medicine a UCLA, Los Angeles, California, USA

    Paul S. Yamauchi

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Noe, M.H., Gelfand, J.M. (2018). Outcomes of Comorbidities with Biologic and Systemic Agents. In: Yamauchi, P. (eds) Biologic and Systemic Agents in Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-66884-0_8

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  • DOI: https://doi.org/10.1007/978-3-319-66884-0_8

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