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The Regulatory and Signaling Roles of Glutathione in Modulating Abiotic Stress Responses and Tolerance

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Book cover Glutathione in Plant Growth, Development, and Stress Tolerance

Abstract

Glutathione (GSH) plays a key role in the maintenance of tissue antioxidant defence and in the regulation of redox-sensitive signal transduction. The size of the GSH pool and its redox status are strongly correlated with the tolerance of plants. The effect of GSH on plant stress resistance is achieved mainly through the cycle of ascorbate (AsA)-GSH producing dehydroascorbate (DHA) re-reduction, in which GSH is intermediate in the recycling of H2O2 reduction and the recycling of GSH is regulated by the glutathione reductase (GR) enzyme. Under oxidative stress, H2O2 and reactive oxygen species (ROS) can be reduced by GSH, while GSH is oxidized to oxidized glutathione (GSSG). Under normal physiological conditions, GSSG can be reduced to GSH by GR in the presence and with the involvement of NADPH, thus creating the redox cycle. AsA/DHA, GSH/GSSG, NADPH/NADP are the three most important interconnected and coordinated redox pairs in plant cells, and plants can scavenge ROS and strengthen their resistance to abiotic stresses by modulating the status of redox pairs; thus the redox metabolism pathways are initiated by diverse environmental stresses. In addition, GSH can regulate the ROS signal transduction pathway, and ROS levels depend on the redox status of redox pairs in plant cells. GSH can activate the genes involved in phytoalexin biosynthesis to repress the accumulation of plant toxin. H2O2 can strengthen this effect through the up-regulation of GSSG. When H2O2 reaches a higher level, the biosynthesis of GSH is stimulated, while GSH, on the other hand, can mediate the response of the plant to the H2O2 signal.

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Authors and Affiliations

  1. College of Horticulture, Nanjng Agricultural University, Jiangsu Nanjing City, 210095, China

    Wang Chen, Leng Xiangpeng, Zhang Wenying & Fang Jinggui

Authors
  1. Wang Chen
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  2. Leng Xiangpeng
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  3. Zhang Wenying
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  4. Fang Jinggui
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Corresponding author

Correspondence to Fang Jinggui .

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Editors and Affiliations

  1. Department of Genetics and Plant Breeding, Bangladesh Agricultural University, Mymensingh, Bangladesh

    Mohammad Anwar Hossain

  2. Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh

    Mohammad Golam Mostofa

  3. Department of Plant Breeding, CEBAS-CSIC, Murcia, Murcia, Spain

    Pedro Diaz-Vivancos

  4. Department of Botany, University of Otago, Dunedin, Otago, New Zealand

    David J Burritt

  5. Department of Applied Biological Science, Kagawa University, Kagawa, Japan

    Masayuki Fujita

  6. RIKEN Center for Sustainable Resource Science, Signaling Pathway Research Unit, Yokohama, Japan

    Lam-Son Phan Tran

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Chen, W., Xiangpeng, L., Wenying, Z., Jinggui, F. (2017). The Regulatory and Signaling Roles of Glutathione in Modulating Abiotic Stress Responses and Tolerance. In: Hossain, M., Mostofa, M., Diaz-Vivancos, P., Burritt, D., Fujita, M., Tran, LS. (eds) Glutathione in Plant Growth, Development, and Stress Tolerance. Springer, Cham. https://doi.org/10.1007/978-3-319-66682-2_7

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