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High-Performance Paper Microfluidic Malaria Test for Low-Resource Settings

  • Tinny Liang
  • Elain FuEmail author
Chapter

Abstract

In this chapter, we describe the application of paper microfluidics to develop a high-performance malaria test appropriate for use in low-resource settings. Malaria ranks in the top three for infectious disease burden worldwide, resulting in about two million deaths per year. Gold standard diagnostic tests for malaria use multistep protocols that require laboratory facilities and are often not accessible to patients in the developing world. Lateral flow tests are simple bioassays that have been used in low-resource settings for decades but can lack the sensitivity needed for clinical utility. Using paper microfluidic tools to automate the multistep sample processing that is characteristic of laboratory tests, we have developed a signal-amplified immunoassay for malaria detection with a higher sensitivity and a lower limit of detection than conventional lateral flow tests. Alternative fluid control tools are described within the same malaria system, and their potential for use in other systems is discussed.

Keywords

Paper microfluidics Point-of-care diagnostic testing Immunoassays Malaria diagnosis Low-resource settings 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.University of WashingtonSeattleUSA
  2. 2.School of Chemical, Biological, and Environmental Engineering, Oregon State UniversityCorvallisUSA

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