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G-Protein-Coupled Receptors: Membrane Diffusion and Organization Matter

Part of the Springer Series in Biophysics book series (BIOPHYSICS,volume 20)

Abstract

G-protein coupled receptors constitute an important family of membrane proteins. They are involved in numerous signaling pathways. The efficiency and regulation of these signaling events depend on the organization of the receptors with their different partners in the plasma membrane, and the way this organization influences the encounters between them. By studying the dynamics of the receptors and their partners in the plasma membrane, important information can be obtained on this membrane organization. In this chapter, we will first review experimental techniques used to study receptor dynamics. Then we discuss how the membrane environment influences receptor dynamics, and how measurements of this dynamics can inform us on interactions of the receptors with their signaling partners and on the effect of ligands. We finish by discussing recent theoretical advances on models of receptor organization, in particular the cluster phases, which provide a coherent framework for the understanding of this organization.

Keywords

  • G Protein-coupled Receptors (GPCRs)
  • Membrane Environment
  • Signaling Partners
  • Fluorescence Recovery After Photobleaching (FRAP)
  • Receptor Diffusion

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 11.1
Fig. 11.2

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Correspondence to Laurence Salomé .

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Haanappel, E., Salomé, L. (2017). G-Protein-Coupled Receptors: Membrane Diffusion and Organization Matter. In: Chattopadhyay, A. (eds) Membrane Organization and Dynamics . Springer Series in Biophysics, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-319-66601-3_11

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