Skip to main content
SpringerLink
Log in
Book cover

Endophytes: Biology and Biotechnology pp 59–98Cite as

Harnessing Fungal Endophytes for Plant and Human Health

  • Chapter
  • First Online:

Part of the book series: Sustainable Development and Biodiversity ((SDEB,volume 15))

Abstract

Endophytic fungi reside inside the healthy tissues of plants. Expansion of the world population has increased the health problems in human and plant and drug resistance in pathogens. Endophytic fungi have the ability to benefit plant growth, metabolism and defense against pathogens, herbivores, insects, etc. They can produce various potential commercially valued secondary metabolites. This has generated worldwide interest among the researchers to study and exploit them for applications in pharmacy and agriculture. Extensive research has led to the discovery of endophytic fungi which provides a great source of medicine for therapeutic applications in human and plant protection under adverse conditions. Secondary metabolites isolated from endophytes possess antimicrobial, antioxidant, cytotoxic activities. It is believed that screening for antimicrobial compounds from endophytes is a promising way to overcome the increasing threat of drug resistant strains of human and plant pathogen. In this review, many important, well-studied areas regarding endophytic fungi and their potential secondary metabolites are presented. Metabolomics and metagenomics of fungal endophytes have also been described. This source of noble compound (secondary metabolites) would bring the endophytic fungi to light to be utilized in the field of pharmacy and agriculture. Metagenomics of endophytes is very important now a day to study the diversity of the endophytic fungi in its environment because all endophytes are not culturable from the host.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Ahmed M, Hussain M, Dhar MK, Kaul S (2012) Isolation of microbial endophytes from some ethnomedicinal plants of Jammu and Kashmir. J Nat Prod Plant Resour 2(2):215–220

    Google Scholar 

  • Alfaro AP, Bayman P (2011) Hidden fungi, emergent properties: endophytes and microbiomes. Ann Rev Phytopath 49:291–315

    Article  CAS  Google Scholar 

  • Aly AH, Edrada ER, Indriani ID, Wray WE, Totzke F, Zirrgiebel U, Schachtele C, Kubbutat MHG, Lin WH (2008) Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. J Nat Prod 71:972–980

    Article  CAS  PubMed  Google Scholar 

  • Amin N, Fitrianti M, Rahim D (2015) Isolation and characterization of endophytic fungi from medicinal plant, buah Makassar (Makassar fruit: Brucea javanica). J Chem Pharma Res 7(1):757–762

    Google Scholar 

  • Amna T, Puri SC, Verma V, Sharma JP, Khajuria RK, Musarrat J, Spiteller M, Qazi GN (2006) Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin. Can J Microbiol 52:189–196

    Article  CAS  PubMed  Google Scholar 

  • Antunes PM, Miller J, Carvalho LM, Klironomos JN, Newman JA (2008) Even after death the endophytic fungus of Schedonorus phoenix reduces the arbuscular mycorrhizas of other plants. Funct Ecol 22:912–918

    Article  Google Scholar 

  • Arnold AE (2003) Fungal endophytes limit pathogen damage in a tropical tree. Proc Nat Acad Sci 100(26):15649–15654

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arnold AE, Lewis LC (2005) Ecology and evolution of fungal endophytes and their roles against insects. In: Vega FE, Blackwell M (eds) Insect-fungal association: ecology and evolution. Oxford University Press, New York, pp 74–90

    Google Scholar 

  • Athman SY, Dubois T, Coyne D, Gold CS, Labuschagne N, Viljoen A (2006) Effect of endophytic Fusarium oxysporum on host preference of Radopholus similis to tissue culture banana plants. J Nematology 38(4):455–460

    Google Scholar 

  • Azevedo JL, Jr WM, Pereira JO, Araujo WL (2000) Endophytic microorganisms: a review on insect control and recent advances on tropical plants. Elec J Biotechnol 3(1):40–65

    Google Scholar 

  • Bacon CW, Porter JK, Robbins JD, Luttrell ES (1977) Epichloe typhina from toxic tall fescue grasses. Appl Environ Microbiol 34(5):576–581

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bhagobaty RK, Joshi SR (2011) Metabolite profiling of endophytic fungal isolates of five ethno-pharmacologically important plants of Meghalaya, India. J Metabol Syst Biol 2(2):20–31

    CAS  Google Scholar 

  • Bhimba BV, Franco DAAD, Jose GM, Mathew JM, Joel EL (2011) Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4. Asian Pacific J Trop Biomed 1(3):223–226

    Article  CAS  Google Scholar 

  • Bier J (1995) Thesis: Relationship between transmission mode and mutualism in the grass-endohyte. Indiana University, Bloomington

    Google Scholar 

  • Bills GF (1996) Isolation and Analysis of Endophytic fungal communities from woody plants. In: Redin S, Carris LM (eds) Systematics, ecology and evolution of endophytic fungi in grasses and woody plants. APS Press, St. Paul, pp 31–65

    Google Scholar 

  • Bills GF, Giacobbe RA, Lee SH, Pelaez F, Tkacz JS (1992) Tremorgenic mycotoxins paspalitrem A and C from a tropical Phomopsis. Mycologic Res 96:977–983

    Article  CAS  Google Scholar 

  • Bills G, Dombrowski A, Pelaez F, Polishook J, An Z (2002) In Watling R, Frankland JC, Ainsworth AM, Issac S, Robinson CH (eds) Tropical mycology: micromycetes, vol 2. CABI Publishing, New York, pp 165–194

    Google Scholar 

  • Bisht DDR, Sharma D, Agrawal PK (2016) Antagonistic and antibacterial activity of endophytic fungi isolated from needle of Cupressus torulosa. Asian J Pharma Clin Res 9(3):1–7

    Google Scholar 

  • Bonnet M, Camares O, Veisseire P (2000) Effects of zinc and influence of Acremonium lolii on growth parameters, chlorophyll-a fluorescence and antioxidant enzyme activities of ryegrass (Lolium perenne L. cv Apollo). J Exp Bot 51(346):945–953

    CAS  PubMed  Google Scholar 

  • Briskin DP, Leroy A, Gawienowski M (2000) Influence of nitrogen on the production of hypericins by St. John’s wort. Plant Physiol Biochem 38:413–420

    Article  CAS  Google Scholar 

  • Calhoun LA, Finddrlay JA, Miller JD, Whitney NJ (1992) Metabolites toxic to spruce budworm from balsam fir needle endophytes. Mycolog Res 96:281–286

    Article  Google Scholar 

  • Camehl I, Drzewiecki C, Vadassery J, Shahollari B, Sherameti I, Forzani C, Munnik T, Hirt H, Oelmuller R (2011) The OXI1 kinase pathway mediates Piriformospora indica-induced growth promotion in Arabidopsis. PLoS Pathog 7(5):e1002051

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carrol G (1988) Fungal endophytes in stems and leaves: from latent pathogen to mutualistic symbiont. Ecology 69(1):2–9

    Article  Google Scholar 

  • Casella TM, Eparvier V, Mandavid H, Bendelac A, Odonne G, Dayan L, Duplais C, Espindola LS, Stien D (2013) Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: isolation of antibacterial agent pyrrocidin C from Lewia infectoria SNB-GTC2402. Phytochemistry 96:370–377

    Article  CAS  PubMed  Google Scholar 

  • Cellarova E, Daxnerova Z, Kimakova K, Haluskova J (1994) The variability of hypericin content in the regenerants of Hypericum perforatum. Acta Biotechnol 14:267–274

    Article  CAS  Google Scholar 

  • Chetri BK, Maharjan S, Budhathoki U (2013) Endophytic fungi associated with twigs of Buddleja asiatica lour. Kathmandu Univ J Sci Eng Technol 9:90–95

    Google Scholar 

  • Chitnis V, Patil S, Kant R (2000) Hospital effluent: a source of multiple drug-resistant bacteria. Curr Sci 79:83–89

    Google Scholar 

  • Clay K (1986) Microbiology of the phylosphere. In: Fokkenna NJ, Heuvel VDJ (eds) Grass endophyte. Cambridge University Press, Cambridge, pp 188–204

    Google Scholar 

  • Clay K, Schardl C (2002) Evolution origin and ecological consequences of endophyte symbiosis with grasses. Am Naturalist 160:99–127

    Article  Google Scholar 

  • Clay K, Holah J, Rudgers JA (2005) Herbivores cause a rapid increase in hereditary symbiosis and alter plant community composition. Proc Natl Acad Sci USA 102:12465–12470

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Claydon N, Grove JF, Pople M (1985) Elm bark beetle boring and feeding deterrents from Phomopsis oblonga. Phytochemistry 24:937–943

    Article  CAS  Google Scholar 

  • Cui HB, Mei WL, Miao CD, Lin HP, Hong K, Dai HF (2008) Antibacterial constituents from the endophytic fungus Penicillium sp. 0935030 of mangrove plant Acrostchum aureurm. Chemical J Chin Univ 33:407–410

    CAS  Google Scholar 

  • Cui JL, Guo TT, Ren ZX, Zhang NS, Wang ML (2015) Diversity and antioxidant activity of culturable endophytic fungi from alpine plants of Rhodiola crenulata, R. angusta, and R. sachalinensis. PlosOne 10(3):e0118204

    Google Scholar 

  • Daleyi CMD (2002) Transmission of multidrug-resistant tuberculosis limited by man or nature. Am J Resp Crit Care Med 165:742–743

    Article  Google Scholar 

  • Dandu A, Tartte V, Duggina P, Netala VR, Kalla CM, Nagam V, Desaraju SB (2013) Isolation and characterization of endophytic fungi from endemic medicinal plants of tirumala hills. Int J Life Sci Biotechnol Pharma Res 2(3):367–373

    Google Scholar 

  • Debbab A, Aly AH, Ru AEE, Muller WEG, Mosaddak M, Hakiki A, Ebel R, Proksch P (2009) Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Moroco. Biotechnol Agronom Soc Environ 13(2):229–234

    Google Scholar 

  • Desai S, Metrani R, Vantamuri S, Ginigeri V, Phadke K, Hungund B (2012) Phytochemical analysis, antimicrobial and antitumour screening of endophytes of Tinospora cordifolia. Int J Pharma Bio Sci 3(4):533–540

    Google Scholar 

  • Desale MG, Bodhankar MG (2013) Antimicrobial activity of endophytic fungi isolated from Vitex negundo Linn. Int J Curr Microbiol Appl Sci 2(12):389–395

    Google Scholar 

  • Devi NN, Prabakaran JJ (2014) Bioactive metabolites from an endophytic fungus Penicillium sp. isolated from Centella asiatica. Curr Res Environ Appl Mycol 4(1):34–43

    Google Scholar 

  • Devi NN, Singh MS (2013) GC-MS analysis of metabolites from endophytic fungus Colletotrichum gloeosporioides isolated from Phlogacanthus thyrsiflorus Nees. Int J Pharma Sci Rev Res 23(2):292–295

    Google Scholar 

  • Dhankhar S, Kumar S, Dhankhar S, Yadav JP (2012) Antioxidant activity of fungal endophytes isolated from Salvadora oleoidesdecne. Int J Pharma Pharma Sciences 4(2):975–1491

    Google Scholar 

  • Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD (1996) Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Nat Acad Sci USA 93:6025–6030

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dua G, Wang ZC, Hub WY, Yan KL, Wang XL, Yang HM, Yang HY, Gao YH, Liu Q, Hu QF (2016) Three new 3-methyl-2-arylbenzofurans from the fermentation products of an endophytic fungus Phomopsis sp. and their anti-TMV activity. Phytochem Lett 1144:1–4

    Google Scholar 

  • Eatona CJ, Coxa MP, Scott B (2011) What triggers grass endophytes to switch from mutualism to pathogenism? Plant Sci 180:190–195

    Article  CAS  Google Scholar 

  • Edwards EF (1997) New fatty acid-based signals, a lesson from the plant world. Science 5314:912–913

    Google Scholar 

  • Elfita Muharni, Indah T (2011) Secondary metabolite of Aspergillus fumigatus, endophytic fungi of the medicinal plant Garcinia griffithii. Makara Sains 15(2):124–128

    Google Scholar 

  • Eyberger AL, Dondapati R, Porter JR (2006) Endophyte fungal isolate from Podophyllum peltatum produces podophyllotoxin. J Nat Prod 69(8):1121–1124

    Article  CAS  PubMed  Google Scholar 

  • Fathima BS, Abhinandan D, Kumar BS, Mohan BR (2013) Mathematical modelling of an endophytic fungus Fusarium oxysporum NFX06 isolated from Nothapodytes foetida. Int J Chem Chemic Eng 3(2):123–130

    Google Scholar 

  • Fischer PJ, Petrini O, Scott LHM (1994) The distribution of some fungal and bacterial endophytes in maize (Zea mays L.). New Phytopathol 122(2):299–305

    Google Scholar 

  • Gangadevi V, Muthumary J (2008) Taxol, an anticancer drug produced by an endophytic fungus Bartalinia robillardoides Tassi, isolated from a medicinal plant, Aegle marmelos Correa ex Roxb. World J Microbiol Biotechnol 24:717–724

    Article  CAS  Google Scholar 

  • Garcia A, Rhoden SA, Filho CJR, Nakamura CV, Pamphile JA (2012) Diversity of foliar endophytic fungi from the medicinal plant Sapindus saponaria L. and their localization by scanning electron microscopy. Biol Res 45:139–148

    Article  PubMed  CAS  Google Scholar 

  • Garraway MO, Evans RC (1984) In: John (ed.) Fungal nutrition and physiology secondary metabolites. Wiley & Sons, New York, pp 336–366

    Google Scholar 

  • Gaynor DL, Hunt WF (1983) The relationship between nitrogen supply, endophytic fungus and Argentine stem weevil resistance in ryegrass. Proc New Zealand Grassland Asso 44:257–263

    Google Scholar 

  • Gond SK, Verma VC, Mishra A, Kharwar RN (2010) Management of fungal plant pathogens. In Arya A, Perello A (eds) Role of fungal endophytes in plant protection, vol 632. CABI Publishing, pp 183–196

    Google Scholar 

  • Goveas SW, Madtha R, Nivas SK, D’Souza L (2011) Isolation of endophytic fungi from Coscinium fenestratum-a red listed endangered medicinal plant. Eur Asian J Bio Sci 5:48–53

    Article  Google Scholar 

  • Greenfield M, Parejaa R, Ortiza V, Gomez-Jimeneza MI, Vegab FE, Parsa S (2015) A novel method to scale up fungal endophyte isolations. Bio Sci Technol 25(10):1208–1212

    Article  Google Scholar 

  • Guillet G, Podeszfinski C, Regnault RC, Arnason JT, Philogene BJR (2000) Behavioral and biochemical adaptations of generalist and specialist herbivorous insects feeding on Hypericum perforatum (Guttiferae). Environ Entomol 29:135–139

    Article  CAS  Google Scholar 

  • Guo H, Ecker JR (2004) The ethylene signaling pathway: new insights. Curr Opin Plant Biol 7(1):40–49

    Article  CAS  PubMed  Google Scholar 

  • Guo BH, Wang YC, Zhou XW, Hu K, Tan F, Miao ZQ, Tang KX (2006) An endophytic Taxol-producing fungus BT2 isolated from Taxus chinensis var. mairei. African. J Biotechnol 5(10):875–887

    CAS  Google Scholar 

  • Gurney KA, Mantle PG (1993) Biosynthesis of 1-n-methylalbonoursin by an endophytic Streptomyces sp. Isolated from perennial ryegrass. J Nat Prod 56(7):1194–1198

    Article  CAS  Google Scholar 

  • Harper JK, Arif AM, Ford EJ, Strobel GA, Porko JA, Tomer DP, Oneill KL, Heider EJ, Grant DM (2003) Pestacin: a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities. Tetrahedron 59(14):2471–2476

    Article  CAS  Google Scholar 

  • Herre EA, Mejia LC, Kyllo DA, Rojas E, Maynard Z, Butler A, Bael SAV (2007) Ecological implications of antipathogen effects of tropical fungal endophytes and mycorhizae. Ecology 88(3):550–558

    Article  PubMed  Google Scholar 

  • Hsiao Y, Chang HS, Liu TW, Hsieh SY, Yuan GF, Cheng MJ, Chen IS (2016) Secondary metabolites and bioactivity of the endophytic fungus Phomopsis theicola from Taiwanese endemic plant. Rec Nat Prod 10(2):189–194

    CAS  Google Scholar 

  • Huang WY, Cai YZ, Xing J, Corke H, Sun M (2007) A potential antioxidant resource: endophytic fungi from medicinal plants. Econ Bot 61(1):14–30

    Article  CAS  Google Scholar 

  • Huang WY, Cai YZ, Hyde KD, Corke H, Sun M (2008) Biodiversity of endophytic fungi associated with 29 traditional Chinese medicinal plants. Fungal Diver 33:61–75

    Google Scholar 

  • Ikeda H, Fukuda T, Yokoyama J (2016) Endophytic fungi associated with a holoparasitic plant, Balanophora japonica (Balanophoraceae). Am J Plant Sci 7:152–158

    Article  CAS  Google Scholar 

  • Jalgaonwala RE, Mohite BV, Mahajan RT (2011) A review: Natural products from plant associated endophytic fungi 1:21–32

    Google Scholar 

  • Jayanthia G, Kamalraja S, Karthikeyanb K, Muthumarya J (2011) Antimicrobial and antioxidant activity of the endophytic fungus Phomopsis sp. GJJM07 isolated from Mesua ferrea. Int J Curr Sci 1:85–90

    Google Scholar 

  • Khan R (2007) Isolation, identification and cultivation of endophytic fungi from medicinal plants for the production and characterization of bioactive fungal metabolites. PhD thesis

    Google Scholar 

  • Khan R, Shahzad S, Choudhary MI, Khan SA, Ahmad A (2010) Communities of endophytic fungi in medicinal plant Withania somnifera. Pak J Bot 42(2):1281–1287

    Google Scholar 

  • Khan AL, Hamayun M, Hussain J, Kang SM, Lee IJ (2012) The newly isolated endophytic fungus Paraconiothyrium sp. LK1 Produces Ascotoxin. Molecules 17:1103–1112

    Article  CAS  PubMed  Google Scholar 

  • Kim H, Chen F, Wu C, Wang X, Chung HY, Jin Z (2008) Evaluation of antioxidant activity of Australian tea tree (Melabuca alternifolia) oil and its components. J Agric Food Chem 52:2849–2854

    Article  CAS  Google Scholar 

  • Knop M, Pacyna S, Voloshchuk N, Kjant S, Mullenborn C, Steiner U, Kirchmair M, Scherer HW, Schulz M (2007) Zea Mays: Benzoxalinone Detoxification under sulfur deficiency conditions-A complex allelopathic alliance including endophytic Fusarium verticilloides. J Chem Ecol 33(2):225–237

    Article  CAS  PubMed  Google Scholar 

  • Kumar S, Kaushik N, Proksch P (2013) Identification of antifungal principle in the solvent extract of an endophytic fungus Chaetomium globosum from Withania somnifera. SpringerPlus 2:37

    Article  PubMed  PubMed Central  Google Scholar 

  • Kumar S, Upadhyay R, Agarwal RP, Sandhu SS (2016) Antibacterial activity of some isolated endophytic fungi from Menthe viridis. Int J Appl Biol Pharma Technol 7(1):239–248

    Google Scholar 

  • Kusari S, Lamshoft M, Zuhl KS, Spiteller M (2008) An endophytic fungus from Hypericum perforatum that produces Hypericin. J Nat Prod 71(2):159–162

    Article  CAS  PubMed  Google Scholar 

  • Kusari S, Lamshoft M, Zuhlke S, Spiteller M (2009) Aspergillus fumigates Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin. J Appl Microbiol 107(3):1019–1030

    Article  CAS  PubMed  Google Scholar 

  • Kusari S, Kosuth J, Cellarova E, Spiteller M (2011) Survival-strategies of endophytic Fusarium solani against indigenous camptothecin biosynthesis. Fungal Ecol 4:219–223

    Article  Google Scholar 

  • Kusari S, Hertweck C, Spiteller M (2012) Chemical ecology of endophytic fungi: origins of secondary metabolites. Chem Biol 19(7):792–798

    Article  CAS  PubMed  Google Scholar 

  • Kusari S, Pandey SP, Spiteller M (2013) Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites. Phytochemistry 91:81–87

    Article  CAS  PubMed  Google Scholar 

  • Lee JC, Strobel GA, Lobkovsky E, Clardy J (1996) Torreyanic acid: a selective cytotoxic quinine dimmer from the endophytic fungus Pestalotiopsis microspora. J Org Chem 61(10):3232–3233

    Article  CAS  Google Scholar 

  • Li JY, Strobel G, Harper J, Lobkovsky E, Clardy J (2000) Cryptocin, a potent tetramic acid antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Org Lett 2:767–770

    Article  PubMed  CAS  Google Scholar 

  • Li H, Qing C, Zhang Y, Zhao Z (2005a) Screening for endophytic fungi with antitumour and antifungal activities from Chinese medicinal plants. World J Microbiol Biotechnol 21:1515–1519

    Article  Google Scholar 

  • Li Y, Song YC, Liu JY, Ma YM, Tan RX (2005b) Anti-Helicobacter pylori substance from endophytic cultures. World J Microbiol Biotechnol 21:553–558

    Article  CAS  Google Scholar 

  • Li WC, Zhou J, Guo SY, Guo LD (2007) Endophytic fungi associated with lichens in Baihua mountain of Beihing, China. Fungal Divers 25:69–80

    Google Scholar 

  • Li HQ, Li XJ, Wang YL, Zhang Q, Zhang AL, Gao JM, Zhang XC (2011) Antifungal metabolites from Chaetomium globosum, an endophytic fungus in Ginkgo biloba. Biochem Syst Ecol 39(4):876–879

    Article  CAS  Google Scholar 

  • Limsuwan S, Trip EN, Kouwenc TRHM, Piersmac S, Hiranrat A, Mahabusarakam W (2009) Rhodomyrtone: a new candidate as natural antibacterial drug from Rhodomyrtus tomentosa. Phytomedicine 16:645–651

    Article  CAS  PubMed  Google Scholar 

  • Liu CH, Zou XW, Lu H, Tan RX (2001) Antifungal activity of Artemisia annua endophyte cultures against phytopathogenic fungi. J Biotechnol 88:277–282

    Article  CAS  PubMed  Google Scholar 

  • Long HH, Schmidt DD, Baldwin IT (2008) Native bacterial endophytes promote host growth in a species-specific manner; phytohormone manipulations do not result in common growth responses. PLoS ONE 3:e2702

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lu H, Zou WX, Meng JC, Hu J, Tan RX (2000) New bioactive metabolites produced by Colletotrichum sp., an endophytic fungus in Artemisia annua. Plant Sci 151:67–73

    Article  CAS  Google Scholar 

  • Malinowski DP, Belesky DP (2006) Ecological importance of Neotyphodium sp. grass endophyte in agroecosystems. Grassland Sci 52(1):23–28

    Google Scholar 

  • Mandyam K, Jumpponen A (2005) Seeking the elusive function of the root-colonizing dark septate endophytic fungi. Stud Mycol 53:173–189

    Article  Google Scholar 

  • Massod AW, Kaul S, Dhar MK, Dhar KL (2010) GC-MS analysis reveals production of 2-phenylethanol from Aspergillus niger endophytic in rose. J Basic Microbiol 50(1):110–114

    Article  CAS  Google Scholar 

  • Meenatchi A, Velmurugan R, Bagyalakshmi Rajendran A (2016) Climatic dependency on the diversity and distribution of endophytic fungi from Rauvolfia serpentina of Western Ghats. Int J Curr Sci Res 2(2):296–307

    Google Scholar 

  • Meneses EA, Durango DL, Carlos Y, García M (2009) Antifungal activity against postharvest fungi by extracts from colombian propolis. Quim Nova 32(8):2011–2017

    Article  CAS  Google Scholar 

  • Miles CO, Mena DME, Jacobs SWL, Garthwaite I, Lane GA, Prestige RA, Marshal SL, Wilkinson HH, Schardl CL, Ball OJP, Latch CM (1998) Endophytic fungi in indigenous Australasian grasses associated with toxicity to livestock. Appl Environ Microbiol 64:601–606

    CAS  PubMed  PubMed Central  Google Scholar 

  • Muharni E, Munawar, Rizki (2012) Isolation of antioxidant compound from endophytic fungi Acremonium sp. from the twigs of Kandis Gajah. Makara J Sci 16(1):46–50

    Google Scholar 

  • Musavi SF, Balakrishnan RM (2014) A study on the antimicrobial potentials of an endophytic fungus Fusarium oxysporum NFX 06. J Med Bioeng 3(3):162–166

    Google Scholar 

  • Onelli E, Rivetta A, Giorgi A, Bignami M, Cocucci M, Patrignani G (2002) Ultrastructural studies on the developing secretory nodules of Hypericum perforatum. Flora 197:92–102

    Article  Google Scholar 

  • Ownley BH, Mary R, Griffin MR, Klingeman WE, Gwinn KD, Moulton JK, Pereira RM (2008) Beauveria bassiana: endophytic colonization and plant disease control. J Inver Pathol 98:267–270

    Article  CAS  Google Scholar 

  • Pavithra N, Sathish L, Ananda K (2012) Antimicrobial and enzyme activity of endophytic fungi isolated from tulsi. J Pharm Biomed Sci 16(12):1–6

    Google Scholar 

  • Phongpaichit S, Rungjindamai N, Rukachaisirikul V, Sakayaroj J (2006) Antimicrobial activity in cultures of endophytic fungi isolated from Garcinia species. FEMS Immunol Med Microbiol 48:367–372

    Article  CAS  PubMed  Google Scholar 

  • Pieterse CM, Leon RA, Van dES, Van WSC (2009) Networking by small-molecule hormones in plant immunity. Nature Chem Biol 5:308–316

    Google Scholar 

  • Prabavathy D, Nachiyar VC (2013) Cytotoxic Potential and Phytochemical Analysis of Justicia beddomei and its endophytic Aspergillus sp. Asian J Pharma Clin Res 6(5):159–161

    Google Scholar 

  • Premjanu N, Jaynthy C (2015) Identification and characterization of antimicrobial metabolite from an endophytic fungus, Colletotrichum gloeosporioides isolated from Lannea corammenalica. Int J Chem Tech Res 7(1):369–374

    Google Scholar 

  • Prestige RA, Gallagher RT (1988) Endophyte conifers resistance to ryegrass: Argentine stem weevil larval studies. Ecologic Entomol 13:429–435

    Article  Google Scholar 

  • Puri SC, Verma V, Amna T, Qazi GN, Spiteller M (2005) An endophytic fungus from Nothapodytes foetida that produces camptothecin. J Nat Prod 68(12):1717–1719

    Article  CAS  PubMed  Google Scholar 

  • Ranf S, Eschen LL, Pecher P, Lee J, Scheel D (2011) Interplay between calcium signaling and early signaling elements during defense responses to microbe- or damage-associated molecular patterns. Plant J 68:100–113

    Article  CAS  PubMed  Google Scholar 

  • Rasmussen S, Parsons AJ, Newman JA (2009) Metabolomics analysis of the Lolium perenne–Neotyphodium lolii symbiosis: more than just alkaloids? Phytochem Rev. doi:10.1007/s11101-009-9136-6

    Google Scholar 

  • Read JC, Camp BJ (1987) The effect of the fungal endophyte Acremonium coenophialum in tall fescue on animal performance, toxicity and stand maintenance. Agron J 78:848–850

    Article  Google Scholar 

  • Redman RS, Sheehan KB, Stout RG, Rodrigues RJ, Henson JM (2002) Thermo tolerance generated by plant/fungal symbiosis. Science 298:181

    Article  Google Scholar 

  • Rehman AS, Shawla AK, Andrabi R, Sudan P, Sultana P, Verma V, Qazi GN (2008) An endophytic Neurospora sp. from Nothapodytes foetida Producing Camptothecin. Appl Biochem Microbiol 44(2):203–209

    Google Scholar 

  • Roberts C, Andre J (2004) Tall fescue toxicosis and management. Crop Manag, doi:10.1094/cm-2004-0427-01-mg

  • Roberts CA, Benedict HR, Hill NS, Kjallenbach RL, Rottinghaus GE (2005) Determination of ergot alkaloid content in tall fescue by near-infected spectroscopy. Crop Sci 45:778–783

    Article  CAS  Google Scholar 

  • Rodriguez RJ, Henson J, Volkenburgh EV, Hoy M, Wright L, Beckwith F, Kim YO, Redman RS (2008) Stress tolerance in plants via habitat-adapted symbiosis. Int Soc Microb Ecol 2:404–416

    Google Scholar 

  • Rosa LH, Tabanca N, Techen N, Wedge DE, Pan Z, Bernier UR, Becne JJ, Agramonte NM, Walker LA, Moraes RM (2012) Diversity and biological activities of endophytic fungi associated with micropropagated medicinal plant Echinacea purpurea (L.) Moench. Am J Plant Sci 3:1105–1114

    Article  Google Scholar 

  • Rubini MR, Silva RRT, Pomella AWV, Maki CS, Araujo WL, Santos DR, Azavedo JL (2005) Diversity of endophytic fungal community of cacao (Theobroma cacao L.) and biological control of Crinipelli sperniciosa, causal agent of Witches’ Broon disease. Int J Biol Sci 1:24–33

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ryan RP, Germaine K, Franks A, Ryan DJ, Dowling DN (2008) Bacterial endophytes: recent developments and applications. FEMS Microbiol Lett 278:1–9

    Article  CAS  PubMed  Google Scholar 

  • Schardl CL, Leuchtmann A, Spiering MJ (2004) Symbioses of grasses with seed borne fungal endophytes. Ann Rev Plant Biol 55:315–340

    Article  CAS  Google Scholar 

  • Scherlach K, Hertweck C (2009) Triggering cryptic natural product biosynthesis in microorganisms. Org Biomol Chem 7:1753–1760

    Google Scholar 

  • Schroeckh V, Scherlach K, Nutzmann HW, Shelest E, Schmidt HW, Schuemann J, Martin K, Hertweck C, Brakhage AA (2009) Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Nat Acad Sci USA 106:14558–14563

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schulz B, Boyle C, Draeger S, Rommert AK, Khrohn K (2002) Endophytic fungi: a source of noble biologically active secondary metabolites. Mycol Res 106(9):996–1004

    Article  CAS  Google Scholar 

  • Senthilkumar N, Murugesan S, Suresh BD, Rajeskannan C (2014) GC-MS analysis of the extract of endophytic fungus, Phomopsis sp. isolated from tropical tree species of India, Tectona grandis L. Int J Innov Res Sci. Eng Technol 3(3):10176–10179

    Google Scholar 

  • Senyuva HZ, Gilbert J, Ozturkoglu S (2008) Rapid analysis of fungal cultures and dried figs for secondary metabolites by LC/TOF-MS. Analyt Chim Acta 617:97–106

    Article  CAS  Google Scholar 

  • Shiomi HF, Silva HSA, Melo IS, Nunes FV, Brttiol W (2006) Bioprospecting endophytic bacteria for biological control of coffee leaf rust. Sci Agric 63(1):32–39

    Article  Google Scholar 

  • Silvaa GH, Telesa HL, Trevisana HC, Bolzani VDS, Young MCM, Pfenning LH, Eberlind MN, Renato Haddad R, Neto CMC, Araujo AR (2005) New Bioactive Metabolites Produced by Phomopsis cassiae, an Endophytic Fungus in Cassia spectabilis. J Braz Chem Soc 16(6):1463–1466

    Article  Google Scholar 

  • Sirvent T, Stuart B, Gibson DM (2003) Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores. J Chem Ecol 29:2667–2681

    Article  CAS  PubMed  Google Scholar 

  • Sobolev VS, Neff SA, Gloer JB (2008) Localized production of phytoalexins by peanut (Arachis hypogaea) kernels in response to invasion by Aspergillus species. J Agric Food Chem 56:1949–1954

    Article  CAS  PubMed  Google Scholar 

  • Spiering MJ, Moon CD, Wilkinson HH, Schardl CL (2005) Gene cluster for insecticidal loline alkaloids in the grass-endophyte fungus Neotyphodium uncinatum. Genetics 169:1403–1414

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Srinivasan K, Jagadish LK, Shenbhagaraman R, Muthumary J (2010) Antioxidant activity of endophytic fungus Phyllosticta sp. isolated from Guazumato mentosa. J Phytol 2(6):37–41

    Google Scholar 

  • Stierle A, Strobel GA, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae. Science 260:214–216

    Google Scholar 

  • Strayer C et al (2000) Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. Science 289(5480):768–771

    Google Scholar 

  • Strobel GA (2002) Microbial Gifts from rain forests. Can J Plant Pathol 24:14–20

    Article  Google Scholar 

  • Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67(4):491–502

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Strobel G, Yang X, Sears J, Kramer R, Sidhu RS, Hess WH (1996) Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallichiana. Microbiology 142:435–440

    Article  CAS  PubMed  Google Scholar 

  • Strobel GA, Hess WM, Li JY, Sears J, Sidhu RS, Summertell B (1997) Pestalotiopsis guepinii, a taxol-producing endophyte of the wollemi pine, Wollemia nobilis. Aust J Bot 45:1073–1082

    Article  CAS  Google Scholar 

  • Strobel GA, Miller RV, Miller C, Condron M, Teplow DB, Hess WM (1999) Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Microbiology 45:1919–1926

    Article  Google Scholar 

  • Tan RX, Zou WX (2001) Endophytes: a rich source of functional metabolites. Nat Prod Rep 18:448–459

    Article  CAS  PubMed  Google Scholar 

  • Tayung K, Barik BP, Jha DK, Deka DC (2011) Identification and characterization of antimicrobial metabolite from an endophytic fungus, Fusarium solani isolated from bark of Himalayan yew. Mycosphere 2(3):203–2013

    Google Scholar 

  • Tejesvi MV, Mahesh B, Nalini MS, Prakash HS, Kini KR, Subbiah V, Shetty HS (2005) Endophytic Fungal Assemblages from inner bark and twig of Terminalia arjuna W. and A. (Combretaceae). World J Microbiol Biotechnol 2:1535–1540

    Article  Google Scholar 

  • Tejesvi MV, Kini KR, Prakash HS, Subbiah V, Shetty HS (2007) Genetic diversity and antifungal activity of species of Pestalotiopsis isolated as endophytes from medicinal plants. Fungal Divers 24:37–54

    Google Scholar 

  • Terhonen E, Sipari N, Asiegbu FO (2016) Inhibition of phytopathogens by fungal root endophytes of norway spruce biological control. Biol Cont 99:53–63

    Article  Google Scholar 

  • Thrower LB, Lewis DH (1973) Uptake of sugars by Epichloe typhina (Pers. Ex Fr.) Tul, in culture and from its host, Agrostis stolonifer L. New Phytol 72:501–508

    Article  CAS  Google Scholar 

  • Toofanee SB, Dulymamode R (2002) Fungal endlophytes associated with Cordemoya integrifolia. Fungal Divers 11:169–175

    Google Scholar 

  • Tucci M, Ruocco M, Masi LD, Palma MD, Lorito M (2011) The beneficial effect of Trichoderma spp. on tomato is modulated by the plant genotype mpp. Mol. Plant Pathol 12(4):341–354

    Article  CAS  Google Scholar 

  • Turner WB (1976) In: Smith JE, Berry DR (ed) The filamentous fungi polyketides and related metabolites, vol 2. New York, pp 445–474

    Google Scholar 

  • Vadassery J, Ranf S, Drzewiecki C, Mithofer A, Mazars C, Scheel D, Lee J, Oelmuller R (2009) A cell wall extract from the endophytic fungus Piriformospora indica promotes growth of Arabidopsis seedlings and induces intracellular calcium elevation in roots. Plant J 59:193–206

    Article  CAS  PubMed  Google Scholar 

  • Vega FE, Posada F, Aime MC, Ripoll MP, Infante F, Rehner ST (2008) Entomopathogenic fungal endophytes. Biologic Cont 46:72–82

    Google Scholar 

  • Verma P, Prakash S (2010) Efficacy of Chrysosporium tropicum metabolite against mixed population of adult mosquito (Culex quinquefasciatus, Anopheles stephensii, and Aedes aegypti) after purification with flash chromatography. Parasitologic Res 107:163–166

    Article  Google Scholar 

  • Vinagre F, Vargas C, Schwarcz K, Cavalcante J, Nogueira EM, Baldani JI, Ferreira PC, Hemerly AS (2006) SHR5: a novel plant receptor kinase involved in plant-N2-fixing endophytic bacteria association. J Exp Bot 57:559–569

    Article  CAS  PubMed  Google Scholar 

  • Waller F, Aehatz B, Baltruschat H, Fodor J, Becker K, Fischer M, Heier T, Huckelhoven R, Neumann C, Wettstein DV, Franken P, Kogel K (2005) The endophytic fungus Piriformospora indica reprogram barley to salt stress tolerance, disease resistance and higher yield. Proc Nat Acad Sci 102(38):13386–13391

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Li G, Lu H, Zheng Z, Huang Y, Su W (2000) Taxol from Tubercularia sp. strain TF5, an endophytic fungus of Taxus mairei. FEMS Microbiol Lett 193:249–253

    Article  CAS  PubMed  Google Scholar 

  • Waqas M, Khanc AL, Hamayun M, Shahzad R, Kanga SM, Kime JG, Lee IJ (2015) Endophytic fungi promote plant growth and mitigate the adverse effects of stem rot: an example of Penicillium citrinum and Aspergillus terreus. J Plant Interac 10(1):280–287

    Article  CAS  Google Scholar 

  • Webber J (1981) A natural control of Dutch elm disease. Nature London 292:449–451

    Article  Google Scholar 

  • Webera D, Gorzalczanyb S, Martino V, Acevedo C, Sternerd O, Ankea T (2005) Metabolites from Endophytes of the Medicinal Plant Erythrina crista-galli. Naturforsch 60:467–477

    Google Scholar 

  • Wicklow DT, Joshi BK, Gamble WR, Gloer JB, Dowd PF (1998) Antifungal metabolites (Monorden, Monocillin IV, and Cerebrosides) from Humicola fuscoatra Traaen NRRL 22980, a mycoparasite of Aspergillus flavus sclerotia. Appl Environ Microbiol 64:4482–4484

    CAS  PubMed  PubMed Central  Google Scholar 

  • Winter JM, Behnken S, Hertweck C (2011) Genomics-inspired discovery of natural products. Curr Opin Chem Biol 15:22–31

    Article  CAS  PubMed  Google Scholar 

  • Wiyakrutta S, Sriubolmas N, Panphut W, Thongon N, Danwisetkanjana K, Ruangrungsi N, Meevootisom V (2004) Endophytic fungi with anti-microbial, anti-cancer and anti-malarial activities isolated from Thai medicinal plants. World J Microbiol Biotechnol 20:265–272

    Article  Google Scholar 

  • Xia X, Lie TK, Qian X, Zheng Z, Huang Y, Shen Y (2011) Species diversity, distribution, and genetic structure of endophytic and epiphytic Trichoderma associated with banana roots. Microb Ecol 61:619–625

    Article  PubMed  Google Scholar 

  • Xing X, Guo S, Fu J (2010) Biodiversity and distribution of endophytic fungi associated with Panax quinquefolium L. cultivated in a forest reserve. Symbiosis 51:161–166

    Article  Google Scholar 

  • Xing YM, Chen J, Cui JL, Chen XM, Guo SX (2011) Antimicrobial activity and biodiversity of endophytic fungi in Dendrobium devonianum and Dendrobium thyrsiflorum from vietman. Curr Microbiol 62(4):1218–1224

    Article  CAS  PubMed  Google Scholar 

  • Young CA, Felitti S, Shields K, Spangenberg G, Johnson RD, Bryan GT, Saikia S, Scott B (2006) A complex gene cluster for indole-diterpene biosynthesis in the grass endophyte Neotyphodium lolii. Fungal Genet Biol 43:679–693

    Article  CAS  PubMed  Google Scholar 

  • Yuan ZL, Zhang CL, Lin FC (2010) Role of diverse non-systemic fungal endophytes in plant performance and response to stress: progress and approaches. J Plant Growth Regul 29:116–126

    Article  CAS  Google Scholar 

  • Zhang Y, Brock M, Keller NP (2004) Connection of propinuy-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans. Genetics 168:785–794

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Microbial Ecology Laboratory, Department of Botany, Gauhati University, Guwahati, 781014, Assam, India

    Deepanwita Deka, Kumananda Tayung & Dhruva Kumar Jha

Authors
  1. Deepanwita Deka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kumananda Tayung
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dhruva Kumar Jha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dhruva Kumar Jha .

Editor information

Editors and Affiliations

  1. Department of Botany & Microbiology, Gurukul Kangri University, Haridwar, India

    Dinesh K. Maheshwari

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Deka, D., Tayung, K., Jha, D.K. (2017). Harnessing Fungal Endophytes for Plant and Human Health. In: Maheshwari, D. (eds) Endophytes: Biology and Biotechnology. Sustainable Development and Biodiversity, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-66541-2_4

Download citation

Publish with us

Policies and ethics

Search

Navigation