Abstract
Dental pulp tissue engineering has gone a long ways from proof of principle to clinical trials. However, the current clinical trials are limited to the utilization of the same patient’s own dental pulp from another tooth to be removed and to be used to tissue engineer other teeth dental pulp. Dental pulp cell differentiation into different cell linages has been extensively investigated, although the potential use of LIPUS to enhance dental pulp cell differentiation still needs to be explored. This chapter will shed the light on the potential use of LIPUS in tissue engineering dental pulp regardless of the origin of stem cells used in tissue engineered dental pulp. According to the current literature, there is strong evidence that low-intensity pulsed ultrasound (LIPUS) can enhance the body regeneration process after trauma to most tissues. This accelerating regeneration process includes but not limited to many of the dentofacial tissues that have been tested so far except dental enamel. In orthodontics, LIPUS can minimize orthodontically induced teeth root resorption when it is applied during orthodontic treatment by stimulating new cementum and dentin formation that works as a protective layer against root resorption. Also, there is an adequate evidence that LIPUS can also enhance tooth movement at the same time. In addition, LIPUS can stimulate mandibular growth in growing animals and patients. Moreover, the stimulatory effect of LIPUS in enhancing the production of dental and other craniofacial tissue matrices plays an important role in regenerative dentistry, including but not limited to endodontics, dental traumatology, and jaw growth modification and maybe beyond these applications. This chapter also sheds light on these possible future applications as well.
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El-Bialy, T. (2018). Pulp Cell Differentiation and Future Directions of LIPUS. In: El-Bialy, T., Tanaka, E., Aizenbud, D. (eds) Therapeutic Ultrasound in Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-319-66323-4_11
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DOI: https://doi.org/10.1007/978-3-319-66323-4_11
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