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Understanding Proteins as Digital Widgets

  • L. Ridgway Scott
  • Ariel Fernández
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Abstract

Conventional assertions of biology have been qualitative, not quantitative. There is not yet a periodic table to codify protein behavior. Here, we explore quantitative aspects of protein biophysics in what at first seems to be fuzzy territory. Most drugs are small molecules that interact with proteins to interfere with the deleterious behavior of mutant proteins. We give examples of descriptions of protein–drug interactions in the literature that appear murky and confused but become clarified by our more complete analysis.

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Departments of Computer Science and Mathematics, Institute for Biophysical Dynamics, Computation InstituteUniversity of ChicagoChicagoUSA
  2. 2.Collegium Basilea, Institute for Advanced StudyBaselSwitzerland
  3. 3.IAM - Argentine Institute of Mathematics, INQUISUR - Chemistry InstituteCONICET - National Research CouncilBuenos AiresArgentina

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