High-Voltage Pulse Source for Cell Electroporation

Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 644)

Abstract

Electroporation is a experimental non-thermal technique for treatment of tumors. The principle of the method lies in delivering of short high-voltage pulses into the treated tissue. The article is focused on development and test process of impulse power source for these purposes. At first, the property of electroporation device is defined and construction variants are discussed. Next, the used topology of power stage and control circuits is presented. Finally, the power source is tested and measured waveforms are presented.

Keywords

Impulse power source High voltage transformer NanoKnife Electroporation 

References

  1. 1.
    Jourbachi, N., Beroukhim, K., Tafti, B., Kee, S., Lee, E.: Irreversible electroporation (NanoKnife) in cancer treatment. Gastrointest. Interv. 3(1), 8–18 (2014). doi:10.1016/j.gii.2014.02.002. http://linkinghub.elsevier.com/retrieve/pii/S2213179514000078 CrossRefGoogle Scholar
  2. 2.
    Davalos, R., Rubinsky, B.: Temperature considerations during irreversible electroporation. Int. J. Heat Mass Transf. 51(23–24), 5617–5622 (2008). doi:10.1016/j.ijheatmasstransfer.2008.04.046. http://linkinghub.elsevier.com/retrieve/pii/S0017931008002706 CrossRefMATHGoogle Scholar
  3. 3.
    Bertacchini, C., Margotti, P., Bergamini, E., Ronchetti, M., Cadossi, R.: Irreversible electroporation systems for clinical use. Ser. Biomed. Eng. (2010). doi:10.1007/978-3-642-05420-4_12 Google Scholar
  4. 4.
    European Standard EN60601-1 Medical electrical equipment - Part 1: general Requirements for safety, 2nd edn. (1998)Google Scholar
  5. 5.
    European Collateral Standard EN60601-1-2; 2. Collateral standard: electromagnetic compatibility requirements and testsGoogle Scholar
  6. 6.
    UL Standard for Safety for Medical Electrical Equipment, Part 1: general requirements for safety, UL; 60601-1, 1st edn. (2003)Google Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Power Electrical and Electronic EngineeringFEEC BUTBrnoCzech Republic

Personalised recommendations