The Novel Device for Irreversible Electroporation: Thermographic Comparison with Radiofrequency Ablation

Conference paper
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 644)

Abstract

Irreversible electroporation is a relatively new technique for minimal invasive non-thermal ablation treatment of solid tumors. This article describes basics of the method and presents comparative tissue temperature measurements of irreversible electroporation and radiofrequency ablation during and immediately after the procedure. The novel generator for irreversible electroporation was tested. All thermographs were generated by an infrared camera. The experiments were performed ex vivo on a porcine liver. The temperature rose by 3 K and 6 K during electroporation and by 20.7 K and 38.5 K in the case of radiofrequency ablation. This is a significant difference showing that the irreversible electroporation is capable of providing successful tissue ablation without thermal damage. This is advantageous especially in areas adjacent to sensitive structures such as blood vessels, biliary tract, nerves, bronchi etc.

Keywords

Plasma membrane Ablation Reversible electroporation RE IRE Irreversible electroporation Radiofrequency ablation RFA Infrared camera 

References

  1. 1.
    Rubinsky, B.: Irreversible Electroporation, 1st edn. Springer, Berlin (2010)CrossRefMATHGoogle Scholar
  2. 2.
    Šimurda, J.: Bioelektrické jevy. 1. Brno: Fakulta Elektrotechniky a komunikačních technologií VUT (2007)Google Scholar
  3. 3.
  4. 4.
    Chang, D.C., Reese, T.S.: Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy. Biophys. Soc. 58, 1–12 (1990)Google Scholar
  5. 5.
    Chen, X., Ren, Z., Zhu, T., et al.: Electric ablation with irreversible electroporation (IRE) in vital hepatic structures and follow-up investigation. Sci. Rep. 5 (2015). 16233, doi:10.1038/srep16233
  6. 6.
    Novotná, V.: Experimental Use of Novel Pulse Generator for Irreversible Electroporation. In: Student EEICT, Brno, p. 5 (2017)Google Scholar
  7. 7.
    Bernard, V., Andrašina, T., Červinka, D., et al.: A thermographic comparison of irreversible electroporation and radiofrequency ablation. IRBM 38, 26–33 (2017). doi:10.1016/j.irbm.2016.11.001 CrossRefGoogle Scholar
  8. 8.
    Liapi, E., Geschwind, J.-F.H.: Transcatheter and ablative therapeutic approaches for solid malignancies. J. Clin. Oncol. 25, 978–986 (2007). doi:10.1200/JCO.2006.09.8657 CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Power Electrical and Electronic EngineeringFEEC BUTBrnoCzech Republic

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