The Novel Device for Irreversible Electroporation: Thermographic Comparison with Radiofrequency Ablation
Irreversible electroporation is a relatively new technique for minimal invasive non-thermal ablation treatment of solid tumors. This article describes basics of the method and presents comparative tissue temperature measurements of irreversible electroporation and radiofrequency ablation during and immediately after the procedure. The novel generator for irreversible electroporation was tested. All thermographs were generated by an infrared camera. The experiments were performed ex vivo on a porcine liver. The temperature rose by 3 K and 6 K during electroporation and by 20.7 K and 38.5 K in the case of radiofrequency ablation. This is a significant difference showing that the irreversible electroporation is capable of providing successful tissue ablation without thermal damage. This is advantageous especially in areas adjacent to sensitive structures such as blood vessels, biliary tract, nerves, bronchi etc.
KeywordsPlasma membrane Ablation Reversible electroporation RE IRE Irreversible electroporation Radiofrequency ablation RFA Infrared camera
This research work has been carried out in the Centre for Research and Utilization of Renewable Energy (CVVOZE). Authors gratefully acknowledge financial support from the Ministry of Education, Youth and Sports of the Czech Republic under NPU I programme (project No. LO1210).
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