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Myocardial Perfusion Assessment by 3D and 4D Computed Tomography

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Quantification of Biophysical Parameters in Medical Imaging

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Abstract

Quantification of myocardial perfusion is the holy grail of cardiovascular imaging. Computed tomography angiography (CTA) is the most accurate noninvasive diagnostic test to diagnose obstructive coronary artery disease but lacks the ability to quantify the functional relevance of coronary artery stenosis. Using myocardial CT perfusion might enable comprehensive assessment of coronary artery disease by quantification of myocardial blood flow. The rather high radiation dose and the complicated analysis of 4D CT are the main challenges for achieving this goal. This chapter summarizes the current status of myocardial perfusion imaging and describes potential technical and clinical solutions for myocardial perfusion assessment by CT.

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Acknowledgment

Professor Dewey would like to thank his group members S. Feger, S. Lukas, F. Michallek, M. Rief, and E. Zimmermann for an exciting collaboration and excellent work on myocardial perfusion imaging. Professor Kachelrieß would like to thank F. Pisana for support.

Author information

Authors and Affiliations

  1. Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Marc Dewey

  2. Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Marc Kachelrieß

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  1. Marc Dewey
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  2. Marc Kachelrieß
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Correspondence to Marc Dewey .

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Editors and Affiliations

  1. Department of Radiology, Humboldt University of Berlin Charité University Hospital, Berlin, Germany

    Ingolf Sack

  2. Medical Physics and Metrological Information Technology, Physikalisch-Technische Bundesanstalt , Berlin, Germany

    Tobias Schaeffter

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Dewey, M., Kachelrieß, M. (2018). Myocardial Perfusion Assessment by 3D and 4D Computed Tomography. In: Sack, I., Schaeffter, T. (eds) Quantification of Biophysical Parameters in Medical Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-65924-4_23

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  • DOI: https://doi.org/10.1007/978-3-319-65924-4_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-65923-7

  • Online ISBN: 978-3-319-65924-4

  • eBook Packages: MedicineMedicine (R0)

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