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Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology

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Quantification of Biophysical Parameters in Medical Imaging

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Abstract

Cardiovascular magnetic resonance imaging (CMR) has become an indispensable tool in the assessment of cardiac structure, morphology, and function. CMR also affords myocardial tissue characterization and probing of cardiac physiology, both being in the focus of ongoing research. These developments are fueled by the move to ultrahigh magnetic field strengths, which permits enhanced sensitivity and spatial resolution that help to overcome limitations of current clinical MR systems.

This chapter reviews the potential of using CMR as a means to assess physiology in the heart muscle by exploiting quantification of myocardial effective transverse relaxation times (T 2 *) for the better understanding of myocardial (patho)physiology. For this purpose the basic principles of T 2 * mapping, the biophysical mechanisms governing T 2 *, and Otherwise this implies that all preclinical applications of myocardial T 2 * mapping ever done are being presented which is not the case. Technological challenges and solutions for T 2 *-sensitized CMR at ultrahigh magnetic field strengths are discussed followed by a survey of acquisition techniques and post processing approaches. Preliminary results derived from myocardial T 2 * mapping of healthy subjects and in patients at 7.0 T are presented. A concluding section provides an outlook including future developments and potential applications.

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Notes

  1. 1.

    Where 1|ΔB| is the hypothetic magnetic field gradient without macroscopic contributions and 2|ΔB| the magnetic field gradient including macroscopic inhomogeneities

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Authors and Affiliations

  1. Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

    Till Huelnhagen, Teresa Serradas-Duarte, Fabian Hezel, Katharina Paul & Thoralf Niendorf

  2. DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany

    Thoralf Niendorf

  3. MRI.TOOLS GmbH, Berlin, Germany

    Thoralf Niendorf

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  1. Till Huelnhagen
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  2. Teresa Serradas-Duarte
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  5. Thoralf Niendorf
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Correspondence to Thoralf Niendorf .

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  1. Department of Radiology, Humboldt University of Berlin Charité University Hospital, Berlin, Germany

    Ingolf Sack

  2. Medical Physics and Metrological Information Technology, Physikalisch-Technische Bundesanstalt , Berlin, Germany

    Tobias Schaeffter

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Huelnhagen, T., Serradas-Duarte, T., Hezel, F., Paul, K., Niendorf, T. (2018). Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology. In: Sack, I., Schaeffter, T. (eds) Quantification of Biophysical Parameters in Medical Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-65924-4_15

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