Skip to main content
SpringerLink
Log in

Quantification of Macrocirculation and Microcirculation in Brain Using Ultrasound Perfusion Imaging

  • Conference paper
  • First Online:
Intracranial Pressure & Neuromonitoring XVI

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 126))

Abstract

Objective: The aim of this study was to investigate the feasibility of simultaneous visualization of the cerebral macrocirculation and microcirculation, using ultrasound perfusion imaging (UPI). In addition, we studied the sensitivity of this technique for detecting changes in cerebral blood flow (CBF).

Materials and methods: We performed an observational study in ten healthy volunteers. Ultrasound contrast was used for UPI measurements during normoventilation and hyperventilation. For the data analysis of the UPI measurements, an in-house algorithm was used to visualize the DICOM files, calculate parameter images and select regions of interest (ROIs). Next, time intensity curves (TIC) were extracted and perfusion parameters calculated.

Results: Both volume- and velocity-related perfusion parameters were significantly different between the macrocirculation and the parenchymal areas. Hyperventilation-induced decreases in CBF were detectable by UPI in both the macrocirculation and microcirculation, most consistently by the volume-related parameters. The method was safe, with no adverse effects in our population.

Conclusions: Bedside quantification of CBF seems feasible and the technique has a favourable safety profile. Adjustment of current method is required to improve its diagnostic accuracy. Validation studies using a ‘gold standard’ are needed to determine the added value of UPI in neurocritical care monitoring.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  1. Gursoy-Ozdemir Y, Yemisci M, Dalkara T. Microvascular protection is essential for successful neuroprotection in stroke. J Neurochem. 2012;123(Suppl 2):2–11. https://doi.org/10.1111/j.1471-4159.2012.07938.x.

    Article  CAS  PubMed  Google Scholar 

  2. Taccone FS, Su F, Pierrakos C, He X, James S, Dewitte O, Vincent JL, De Backer D. Cerebral microcirculation is impaired during sepsis: an experimental study. Crit Care. 2010;14:R140. https://doi.org/10.1186/cc9205.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Meairs S, Kern R. Intracranial perfusion imaging with ultrasound. Front Neurol Neurosci. 2015;36:57–70. https://doi.org/10.1159/000366237.

    Article  PubMed  Google Scholar 

  4. Shpak O, Verweij M, de Jong N, Versluis M. Droplets, bubbles and ultrasound interactions. Adv Exp Med Biol. 2016;880:157–74. https://doi.org/10.1007/978-3-319-22536-4_9.

    Article  CAS  PubMed  Google Scholar 

  5. Eyding J, Krogias C, Wilkening W, Meves S, Ermert H, Postert T. Parameters of cerebral perfusion in phase-inversion harmonic imaging (PIHI) ultrasound examinations. Ultrasound Med Biol. 2003;29:1379–85.

    Article  PubMed  Google Scholar 

  6. Ohno N, Miyati T, Yamashita M, Narikawa M. Quantitative assessment of tissue perfusion in hepatocellular carcinoma using perflubutane dynamic contrast-enhanced ultrasonography: a preliminary study. Diagnostics. 2015;5:210–8. https://doi.org/10.3390/diagnostics5020210.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Yamada S, Komuro K, Mikami T, Kudo N, Onozuka H, Goto K, Fujii S, Yamamoto K, Kitabatake A. Novel quantitative assessment of myocardial perfusion by harmonic power Doppler imaging during myocardial contrast echocardiography. Heart. 2005;91:183–8. https://doi.org/10.1136/hrt.2004.035857.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Seidel G, Algermissen C, Christoph A, Claassen L, Vidal-Langwasser M, Katzer T. Harmonic imaging of the human brain. Visualization of brain perfusion with ultrasound. Stroke. 2000;31:151–4.

    Article  CAS  PubMed  Google Scholar 

  9. Tang MX, Mulvana H, Gauthier T, Lim AK, Cosgrove DO, Eckersley RJ, Stride E. Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability. Interface Focu.s. 2011;1:520–39. https://doi.org/10.1098/rsfs.2011.0026.

    Article  Google Scholar 

Download references

Conflicts of interest statement

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    Eline J. Vinke, Johannes G. van der Hoeven & Cornelia W. E. Hoedemaekers M.D., Ph.D.

  2. Department of Neurology, Universitätsklinikum Knappschaftskrankenhaus, Ruhr University Bochum, Bochum, Germany

    Jens Eyding

  3. Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    Chris de Korte

  4. MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands

    Cornelis H. Slump

Authors
  1. Eline J. Vinke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jens Eyding
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chris de Korte
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cornelis H. Slump
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Johannes G. van der Hoeven
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Cornelia W. E. Hoedemaekers M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cornelia W. E. Hoedemaekers M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Thomas Heldt

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Vinke, E.J., Eyding, J., de Korte, C., Slump, C.H., van der Hoeven, J.G., Hoedemaekers, C.W.E. (2018). Quantification of Macrocirculation and Microcirculation in Brain Using Ultrasound Perfusion Imaging. In: Heldt, T. (eds) Intracranial Pressure & Neuromonitoring XVI. Acta Neurochirurgica Supplement, vol 126. Springer, Cham. https://doi.org/10.1007/978-3-319-65798-1_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-65798-1_25

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-65797-4

  • Online ISBN: 978-3-319-65798-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation