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Recent Advances in the Stereochemical Outcome of Multicomponent Reactions Involving Convertible Isocyanides

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Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Abstract

Multi-component reactions (MCRs) have become an integral part of organic synthesis as short and very efficient routes to molecular diversity with included varying stereochemistry. MCRs have evolved rapidly in terms of the components used in the reactions and their role on the stereo chemical outcomes. This chapter focuses on covering recent contributions towards MCRs including targeted asymmetric control. Furthermore, advances in MCRs, as reported by many researchers, covering the utility of the convertible isocyanides, stereochemical advances of the Passerini and Ugi reactions and finally, the use of carbohydrates as chiral auxiliaries are examined and discussed.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, School of Green Chemistry and Engineering, University of Toledo, 2801 W. Bancroft St., Wolfe Hall 2232B, Toledo, OH, 43606-3390, USA

    Krishnakant Patel & Peter R. Andreana

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  1. Krishnakant Patel
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  2. Peter R. Andreana
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Correspondence to Peter R. Andreana .

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Editors and Affiliations

  1. Pharmaceutical Sciences Department, Wilkes University, Wilkes-Barre, Pennsylvania, USA

    Zbigniew J. Witczak

  2. Pharmaceutical Sciences Department, Nesbitt School of Pharmacy, Wilkes University, Wilkes-Barre, Pennsylvania, USA

    Roman Bielski

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Patel, K., Andreana, P.R. (2018). Recent Advances in the Stereochemical Outcome of Multicomponent Reactions Involving Convertible Isocyanides. In: Witczak, Z., Bielski, R. (eds) Coupling and Decoupling of Diverse Molecular Units in Glycosciences. Springer, Cham. https://doi.org/10.1007/978-3-319-65587-1_3

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