Keating et al.demonstrated, among men with no comorbidities, ADT was associated with an increase of MI. Risks of MI and diabetes were similarly increased among men with and without specific comorbid illnesses. Previous risk factors for MI were associated with new MI and diabetes, and obesity and rheumatologic disease were also associated with diabetes. This demonstrated traditional risk factors for MI and diabetes were also associated with developing these conditions during ADT but did not significantly modify the risk attributable to ADT. This paper also highlighted the important of screening for cardiovascular disease and diabetes in the ADT population. This was confirmed by Ziaran et al.  who also discovered after 12 months of ADT, BMI, waist to hip ratio, low-density lipoprotein, overall cholesterol increased significantly and (4.2%) were diagnosed with new onset diabetes. This demonstrated ADT leads into unfavourable changes in body composition and unfavourable lipoprotein profile.