Prostate Cancer with F-18 Sodium Fluoride

  • Ana M. Franceschi
  • Robert Matthews


Sodium fluoride F-18 (NaF) is a positron-emitting radiotracer used in imaging patients with suspected bone metastases. NaF PET/MRI provides numerous advantages over the conventional technetium bone scans, most importantly higher sensitivity and specificity, greater spatial resolution, and significantly shorter uptake and scan times.


Sodium fluoride Bone scan Diffusion-weighted imaging F18 Blastic lesion Osseous metastasis Prostate cancer PET/MR 

Suggested Reading

  1. Bastawrous S, Bhargava P, Behnia F, Djang DS, Haseley DR. Newer PET application with an old tracer: role of 18F-NaF skeletal PET/CT in oncologic practice. Radiographics. 2014;34(5):1295–316.Google Scholar
  2. Cook GJ, Azad G, Padhani AR. Bone imaging in prostate cancer: the evolving roles of nuclear medicine and radiology. Clin Transl Imaging. 2016;4(6):439–47.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Li Y, Schiepers C, Lake R, Dadparvar S, Berenji GR. Clinical utility of (18)F-fluoride PET/CT in benign and malignant bone diseases. Bone. 2012;50(1):128–39.Google Scholar
  4. Mosavi F, Johansson S, Sandberg DT, Turesson I, Sörensen J, Ahlström H. Whole-body diffusion-weighted MRI compared with (18)F-NaF PET/CT for detection of bone metastases in patients with high-risk prostate carcinoma. AJR Am J Roentgenol. 2012;199(5):1114–20.Google Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Ana M. Franceschi
    • 1
  • Robert Matthews
    • 1
  1. 1.Department of RadiologyStony Brook University HospitalStony BrookUSA

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