Abstract
Biological clock, or circadian rhythms (CRs) are an indispensable feature of nearly all living organisms; they may be observed at behavioral, physiological or cellular level. However, in mammals internal clock becomes less rhythmic and more vulnerable to external disturbing stimuli with age. In this chapter we briefly describe rodent circadian system physiology, rhythms and clock genes disturbance in aging and age-related diseases, models of genetic (clock genes mutant/knockout mice) and environmental (light-dark regimens manipulation) circadian disturbance. In the end some interventions which may be used to improve circadian output are considered.
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Panchenko, A.V., Gubareva, E.A., Anisimov, V.N. (2017). Circadian System and Aging in Rodent Models. In: Jazwinski, S., Belancio, V., Hill, S. (eds) Circadian Rhythms and Their Impact on Aging. Healthy Ageing and Longevity, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-64543-8_5
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