Abstract
Our aim in this paper is to study properties of a parabolic-elliptic system related with brain lactate kinetics. These equations are obtained from a reaction-diffusion system, when a small parameter vanishes. In particular, we prove the existence and uniqueness of nonnegative solutions and obtain error estimates on the difference of the solutions to the initial reaction-diffusion system and those to the limit one, on bounded time intervals. We also study the linear stability of the unique spatially homogeneous equilibrium.
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References
Agmon, S., Douglis, A., Nirenberg, L.: Estimates near the boundary for solutions of elliptic partial differential equations, I. Commun. Pure Appl. Math. 12, 623–727 (1959)
Agmon, S., Douglis, A., Nirenberg, L.: Estimates near the boundary for solutions of elliptic partial differential equations, II. Commun. Pure Appl. Math. 17, 35–92 (1964)
Alikakos, N.D.: L p bounds of solutions to reaction-diffusion equations. Commun. Partial Differ. Equ. 4, 827–868 (1979)
Aubert, A., Costalat, R.: Interaction between astrocytes and neurons studied using a math- ematical model of compartmentalized energy metabolism. J. Cereb. Blood Flow Metab. 25, 1476–1490 (2005)
Costalat, R., Françoise, J.-P., Menuel, C., Lahutte, M., Vallée, J.-N., de Marco, G., Chiras J., Guillevin, R.: Mathematical modeling of metabolism and hemodynamics. Acta Biotheor. 60, 99–107 (2012)
Guillevin, R., Miranville, A., Perrillat-Mercerot, A.: On a reaction-diffusion system associated with brain lactate kinetics. Electron. J. Differ. Equ. 2017, 1–16 (2017)
Hu, Y., Wilson, G.S.: A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J. Neurochem. 69, 1484–1490 (1997)
Keener, J., Sneyd, J.: Mathematical physiology. In: Interdisciplinary Applied Mathematics, vol. 8, 2nd edn. Springer, New York (2009)
Lahutte-Auboin, M.: Modélisation biomathématique du métabolisme énergétique cérébral: réduction de modèle et approche multi-échelle, application à l’aide à la décision pour la pathologie des gliomes. PhD thesis, Université Pierre et Marie Curie (2015)
Lahutte-Auboin, M., Costalat, R., Françoise, J.-P., Guillevin, R.: Dip and buffering in a fast-slow system associated to brain lactate kinetics (2013, Preprint)
Lahutte-Auboin, M., Guillevin, R, Françoise, J.-P., Vallée, J.-N., Costalat, R.: On a minimal model for hemodynamics and metabolism of lactate: application to low grade glioma and therapeutic strategies. Acta Biotheor. 61, 79–89 (2013)
Mendoza-Juez, B., Martínez-González, A., Calvo, G.F., Peréz-García, V.M.: A mathematical model for the glucose-lactate metabolism of in vitro cancer cells. Bull. Math. Biol. 74, 1125–1142 (2012)
Miranville, A.: A singular reaction-diffusion equation associated with brain lactate kinetics. Math. Models Appl. Sci. 40, 2454–2465 (2017)
Temam, R.: Infinite-Dimensional Dynamical Systems in Mechanics and Physics. Applied Mathematical Sciences, vol. 68, 2nd edn. Springer, New York (1997)
Temam, R.: Navier-Stokes Equations: Theory and Numerical Analysis. AMS Chelsea Publishing, American Mathematical Society, Providence, RI (2001)
Acknowledgements
This paper is dedicated to Gianni Gilardi, with friendship and admiration. The author wishes to thank an anonymous referee for her/his careful reading of the paper and useful comments.
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Miranville, A. (2017). Mathematical Analysis of a Parabolic-Elliptic Model for Brain Lactate Kinetics. In: Colli, P., Favini, A., Rocca, E., Schimperna, G., Sprekels, J. (eds) Solvability, Regularity, and Optimal Control of Boundary Value Problems for PDEs. Springer INdAM Series, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-64489-9_15
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DOI: https://doi.org/10.1007/978-3-319-64489-9_15
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