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Evaluation of Liver Function

  • Vanessa Cowan
Chapter

Introduction

Conventional liver function tests are insensitive and not able to detect discreet injury that affect mostly oxidative pathway of liver metabolism. Assesment of liver function is important for risk estimation prior to liver resections and transplants. This chapter will review limitations of conventional liver function tests and discuss the use of more sensitive, dynamic liver functions tests.

Dynamic (Quantitative) Liver Function Tests

Conventional liver function test measure multiple aspects of liver function and injury. Transaminases such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are intracellular enzymes that are released during hepatocyte injury and reflect the degree of liver injury; for example after ischemia-reperfusion injury. Metabolic function is frequently assessed by measuring albumin and protein levels. Biliary obstruction or injury causes a release of the enzyme alkaline phosphatase that lines the epithelium of the bile...

Keywords

Liver function test Bilirubin Indocyanain green Dynamic liver function tests Monoethylgycinexylidide test Sorbitol clearance 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Transplant InstituteBeth Israel Deaconess Medical CenterBostonUSA

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