Evaluation of Liver Function
Conventional liver function tests are insensitive and not able to detect discreet injury that affect mostly oxidative pathway of liver metabolism. Assesment of liver function is important for risk estimation prior to liver resections and transplants. This chapter will review limitations of conventional liver function tests and discuss the use of more sensitive, dynamic liver functions tests.
Dynamic (Quantitative) Liver Function Tests
Conventional liver function test measure multiple aspects of liver function and injury. Transaminases such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are intracellular enzymes that are released during hepatocyte injury and reflect the degree of liver injury; for example after ischemia-reperfusion injury. Metabolic function is frequently assessed by measuring albumin and protein levels. Biliary obstruction or injury causes a release of the enzyme alkaline phosphatase that lines the epithelium of the bile...
KeywordsLiver function test Bilirubin Indocyanain green Dynamic liver function tests Monoethylgycinexylidide test Sorbitol clearance
- 16.Olmedilla L, Perez-Pena JM, Ripoll C, Garutti I, et al. Early noninvasive measurement of the indocyanine green plasma disappearance rate accurately predicts early graft dysfunction and mortality after deceased donor liver transplantation. Liver Transpl. 2009;15:1247–53.CrossRefPubMedCentralGoogle Scholar